<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23550

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVFRAAQDSYGNSKELVEKCRSTELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIKRCHQLASTVSNHDMCFTQAADSLFFIHEGLQQARAPVYDVPSAIDVLLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVSDGTALIKVDGEFKVLVTLGYRGHLSMWRILHLEQLVGEKNKPIKLELMRRHVLGDDLERRMAAAENPFSILYSVLHDLCVSLVVDTVIRQVQALRQGRWKDAIRFELISDGGMGHAAGSSSMQNPDRESDSSGPRTPGLKIIYWLEFNKNAGMSDSGACPFIKIEPGPDLQIKCIHSNFVIDPLTGKEAEFFLDQSCIDVERLLLRAISCNRYTRLLEIKRELGKNNHVCRAADDVVLQSHLGGPDVEYKHKDDKCFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALKDEMNLSLVDWGKLHSLLPNAACPNQESVREFLSDIRLESSIQNAKGHPSGFSSLVDEVFGLEKGSSASPFSVQNHGSLPSHYGSVPMNLHSLKAGTPSPKWEGGMQISQVNNITKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQLRVLSDSSNDGLGESRSSRLLSPPLPTSSRISLPNSKPNGPQAESLKAAGANSCASTPVSQAMESTGNEDVIPKHDKRSRKRTASDMLNLIPSLQGLENNSAICKRRKILDSSGSQLSLPQGVVPSEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFARGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRQLLGVRADEKSEETSSDAKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVEWESGKEGCTMHVSSDQLWPHTKFLEDFINGAEVSSLLDCIRLTAAPLHALAAATRPARAGPLSSIPKQTGYIQPQGLLGSSTSNIGQPTSGPGGNTAMSAPGGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVFDVVRGQQETVCC
Length1309
PositionTail
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.06
Grand average of hydropathy-0.216
Instability index44.26
Isoelectric point7.19
Molecular weight142918.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23550
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.58|      38|      71|     445|     485|       1
---------------------------------------------------------------------------
  445-  482 (63.57/38.37)	VLRVRA....YASCFFTLGVNIRNGRF.LLQSSQNIVASSALL
  501-  543 (54.01/24.86)	SLRSKSllhlFASIGRVLGLEVFEHGFsTVKVPKNILNGSAML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.69|      41|     596|     353|     434|       2
---------------------------------------------------------------------------
  379-  434 (55.59/103.33)	VERLLLRAISCNRYTRlLEIKRelGKN.NHVC.RaaddvvlqshLGGPDveYKHKDDK
  979- 1021 (73.11/34.43)	VEEVGLRSASSNIWFR.LPFAR..GDSwQHIClR..........LGRPG..CMHWDVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.76|      36|      69|     648|     688|       3
---------------------------------------------------------------------------
  648-  688 (58.82/46.90)	NAKGHPSG....FSslvDEVFGleKGSSASPFSVQNHGSLPSHYG
  716-  755 (56.95/32.84)	NNITKPSGvtnhYS...DSMFS..SGSVKGPVQSNSVGSISTGQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.72|      52|      69|     116|     171|       4
---------------------------------------------------------------------------
  116-  171 (73.03/65.73)	VPSAIDVLLTGSYqRLPKCIEDVGTQYTLNEEQQKPAlkKLDaLVRSKLLEVSLPK
  187-  238 (89.69/63.06)	VDGEFKVLVTLGY.RGHLSMWRILHLEQLVGEKNKPI..KLE.LMRRHVLGDDLER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.14|      16|      16|     828|     843|       5
---------------------------------------------------------------------------
  828-  843 (27.22/15.69)	NSKPNGPQAESLKAAG
  845-  860 (27.92/16.29)	NSCASTPVSQAMESTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.78|      69|     337|     866|     940|      15
---------------------------------------------------------------------------
  866-  940 (112.35/81.07)	PKHDKRSRKRTA.SDMLNLIPSLQGlennsaICKRRKILDSSGSQLSLP.QGVVPSEMISRAEGYSYG..SLIAEANKG
 1210- 1282 (107.43/66.18)	PLHALAAATRPArAGPLSSIPKQTG......YIQPQGLLGSSTSNIGQPtSGPGGNTAMSAPGGLTNQtlSMLAAAGRG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23550 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSVPMNLHSLKAGTPSPKWEGGMQISQVNNITKP
2) GVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDL
3) SLKSPHSVDIVSSTAMDEDQLRVLSDSSNDGLGESRSSRLLSPPLPTSSRISLPNSKPNGPQAESLKAAGANSCASTPVSQAMESTGNEDVIPKHDKRSRKRTASDMLNL
688
723
774
721
772
883










Molecular Recognition Features






MoRF SequenceStartStop




1) LKIIYWL
318
324