<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23549

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVSRAAQDSYSNLKELVEKCRSTELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIKHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVSDGTALIKVDGEFKVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAAAENPFLILYSVLHDLCVSLVMDTVIRQVQALRQGRWKDAIRFELISDGGMGHAAGSSSMQNPDGESDSSGPRTPGLKIIYWLEFDKNAGMSDSGACPFIKIEPGPDLQIKCIHSNFVIDPLTGKEAEFFMDQSCIDVERLLLRAISCNRYTRLLEIKRELGKNNHVCRAADDVVLQSHLGGPDVEYKQKDDKGFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALKDEMNLSLVDWGKLHSLLPNAACPNQESVREFLSDIRLESSIQNAKGHPSGFSSLVDEVFGLEKGSSASPFSVQNHGSLPSHYGSVPMNLHSLKAGTPSPKWEGGMQISQVNNITKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQLRVLSDSSNDGLGESRSSRLLSPPLPTSSRISLPNSKPNGPQAESLKAAGANSCASTPVSQAMESTGNEDVIPKHDKRSRKRTASDMLNLIPSLQGLENNSAICKRRKILDSSGSQLSLPQGVVPSEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFARGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRQLLGVRADEKSEETSSDAKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSFPKQTGYIQPQGLLGSSTSNVGQPTSGPGGNTAMSAPGGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPNFTAQQAGGLANSNNPNPSSSSQLMGANGSRINLPASAAMSRTGNPAAGLNRVGNALAGPSNLALMNSAVSLRRPPGAIVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSNPAQEELSQTEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQIGDMVSAQKPRIELCLENHAGLTTDDNSESSSAFRSNIHYDRNHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPSVSFLGMEGSHGGRACWLRADDWDKCKQRVARTVEVSGSSPADASQGRLKLVADSVQRNLHMCLQGLKDGSGVPANFGAT
Length1804
PositionTail
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.06
Grand average of hydropathy-0.188
Instability index45.77
Isoelectric point7.83
Molecular weight196209.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     469.78|     150|     167|    1183|    1349|       1
---------------------------------------------------------------------------
 1183- 1343 (229.57/152.49)	PHTKFlEDFINgAEVSSLLDCI..RLTAGPLHALAAA..TRPARAGPVPGVAAALSSFPKQTGyIQPQGLLGSSTSNVGQPTSGPgGNTAmsapggLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPY...WIRIMYRKQFAVDMRCFAGdQVWLQPATPP..KE
 1352- 1510 (240.21/120.25)	PCPQF.RPFIM.EHVAQELNGLdpNFTAQQAGGLANSnnPNPSSSSQLMGANGSRINLPASAA.MSRTGNPAAGLNRVGNALAGP.SNLA......LMNSAVSLRRPPGAIVPAHVRGELNTAIIGLGDDGGYgggWVPLVALKKVLRGILKYLG.VLWLFAQLPDllKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.26|      35|     597|     372|     409|       2
---------------------------------------------------------------------------
  372-  409 (56.05/50.79)	MDQSCID.VERLLLRAISCNRYTRlLEIKRelGKN.NHVC
  971- 1007 (56.22/39.16)	MDSLDISyVEEVGLRSASSNIWFR.LPFAR..GDSwQHIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.71|      41|      71|     445|     485|       3
---------------------------------------------------------------------------
  445-  485 (70.09/52.70)	VLRVRAYASCFFTLGV..NIRNGRFLLQSSQNIVASSALLECE
  517-  559 (68.62/51.42)	VLGLEVFEHGFSTVKVpkNILNGSAMLIMAFPDCGSSYFLMME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.82|      34|      70|     646|     683|       4
---------------------------------------------------------------------------
  646-  674 (45.00/21.35)	.............IQNAKGH.PSGFSSLVDEVFGLEKGSSASP
  678-  704 (43.99/24.64)	QNHGS...............lPSHYGSVPMNLHSLKAGTP.SP
  705-  741 (44.83/20.45)	KWEGGmqisqvnnITKPSGV.TNHYS...DSMFS..SGSVKGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.84|      40|     148|     913|     954|       5
---------------------------------------------------------------------------
  913-  954 (64.19/52.49)	PQGVVPSemISRAEGYSYGSLIAEANK.GNAPS.SIYIAALLHV
 1062- 1103 (57.65/39.75)	PDGVVLS..YQSVEVDSIKKLVADIQRlANARTfALGMRQLLGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     384.03|     104|     164|      88|     191|       6
---------------------------------------------------------------------------
   88-  191 (170.99/95.16)	HDMCFTQAADSLFFMHEGLQQAR...APVYDVPS..AIDILLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVSDGTAL.IK.VDGEF
  193-  253 (69.66/34.44)	.......................................VLVTLGY.RGHLSMWRILHLELLVGEKNKPI..KLE.LMRRHVLGDDLERRMAAAE.NPFLIL.YS.V....
  255-  358 (143.39/78.62)	HDLCVSLVMDTVIRQVQALRQGRwkdAIRFELISdgGMGHAAGSSSMQNPDGESDSSGPRT.......PGLKIIYWLEFDKNAGMSDSGACPFIKIEPGPDLqIKcIHSNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.14|      16|      16|     828|     843|       7
---------------------------------------------------------------------------
  828-  843 (27.22/14.53)	NSKPNGPQAESLKAAG
  845-  860 (27.92/15.09)	NSCASTPVSQAMESTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23549 with Med14 domain of Kingdom Viridiplantae
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