<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23493

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQLSWFQFLPNEPDPCFLPDKSNKVDQKDAAMLAVISSHLQLQKEGFLSAWTNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVIETAQSAVSGLRVVASGLWLAPGDVEEVAAALSQALRNCIERALNGLYYMRFGEVFSKFHHFQSEELFRKGQPTVEFVFAATEEAIFVHVIVSSKHIRMLSTGDLEKVLKHSMEAKYRLPVIVSPHGIRGSLVGSSPSDLVKQSYFSTSKFRASSGIIGLPNHVSQGVGCQLRGQNCYVEVSLGFPRLVTDKALQSNKNSVRNLSKLHVAESPAAGRSDHKGSPDHLSDCEKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSSSFIHCAANVDSVEDPWAEINGSRMQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPNELEADADSLTCRQSVVSSGDQLESDGPKLGSKRSRAGVTESLSTATNVPMQDAYMSDFGSMEVNNSAITGVGNEPIGSYWDWGDDDRGVEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFSAPDCGDVNSSPVGVMDVSDQMLLPVGFPSFESFDPPPPAAMEECLSKSQDNLNNSMLSGPVNQTQLSYTREFDHIMKTEAMMTFAPEFGAVETPSSELSTTLFKSPYFPKSRKADSSNSSTNSYLYGAAPPSSPCIEGSEGKNGMVINSKTCSGTHDATMNLHSKNYYTYVESRKDINDKKTVTCKNDSIVKSDGMVSPPFSNIGSNAVAKSGLKMNEGTLESEHLLLSAKTLLATDVMCVMFQASMCRLRHTLLSSSNIMPLGFGRPTGVAFFNQLPGDPSTTTENISGKYEVKKKENIPVRIAGDIEGGMLDGHLNAPVGVWRTVGVSKPMKPSSSPNMEVGPSYSHNSFSDEGLLSYSQRKPLQELLDGIALLVQQAISFVDLALDVDCGDGPYGLLALQEQWRRGFCCGPSMIHAGCGGTLASSHSLDIAGVELVDPLSADVHASTVISLLQSDMKTALKSVFPHLEGPLSVTDWCKGRNQSVDTGSILDGVSAESGISECRDSSEPLSPSLSSIGGSSSIKVSNMIDGAKVEENSQRRSGQDMCSSESEQQPCPRLKPTIIALPFPSLLVGYQDDWLKTSANCLQHWEKAPLEPYGLTKPLTYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESGKLSSCGFVLLDCPQSMKIESSNASLVGSISDYFLSLSNGWDLTSYLKSLSKALRALKLGSCFSSNPSEGSNSSCMVIYVVCPFPDPSAVLQTVIESSVAIGSVIQQSDRDRRSLLHSQVSKALNVSATVDETSASNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVILKETAFTVYSKARRISRGVSSDFSQSAFSSRSHSVLTQMPSPISGMWKDCVGPRMAGHSIPREGDIDASLRTGTWDNSWQPTRTGGLSCDPSRSGDNFLQDETRYMFEPLFILAEPGSVEHGVSAVGSPNSDSSKTMADDGSGNYMQNTSTTGSADSASSIDGSGSDQKTLPSLHCCYGWTEDWRWLVCIWTDSRGELLDSNIFPFGGISGRQDTKGLQCLFVQVLQQGCLILQSCDTGLAKPRDFVIARIGGFFELEYLEWQKAIYSVGGSEMKKWPMQLRKSMSDGLSATSNGSSLQQPEMSMIPERALPSSPSPLYSPHAKPTGFMKGSLGQPAARKQLMAGHMVDNSRGLLHWAQSISFVSVSMDHTLQLVLPADSSPGYIEGFTPVKSLGSASSAYILIPSPSMRFLPPTTLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGTNIPQEKILRGINKQGGRIPSWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1951
PositionKinase
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.07
Grand average of hydropathy-0.224
Instability index52.37
Isoelectric point5.45
Molecular weight211321.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP23493
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.69|      25|      28|    1425|    1451|       1
---------------------------------------------------------------------------
 1425- 1451 (46.19/27.05)	GMWKDCVGP.RMAGHSI.P.REGdiDASLR
 1453- 1480 (39.50/17.63)	GTWDNSWQPtRTGGLSCdPsRSG..DNFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     659.06|     190|     201|    1489|    1688|       2
---------------------------------------------------------------------------
  389-  467 (37.83/11.07)	....................................................................GSRMQNS.YDSSSNSNSS..SIsslsaS........SSDSDYKTTgPN.....ELEADA..DSLTCR..QSvVSSGDQLESDGPKLGSKRSRAGvTESL..............................................................................
 1045- 1146 (92.69/45.16)	SILDGVSAESGISECRDSS.....................EPLS..PSLSSIGGSSSIKVSNMI.DGA.KVEENS.QRRSGQDMCS..SE.....SeqqpcprlKPTIIALPF.PSL..LVGYQDDWlkTSANCLqhW...........................................................................................................
 1488- 1662 (275.24/169.37)	........................E........PLF.ILAEPGSVEHGVSAVGSPNSDSSKTMAdDGSGNYMQNT.STTGSADSAS..SI.....D........GSGSDQKTL.PSLHCCYGWTEDW..RWLVCI..WT.DSRGELLDSNIFPFGGISGRQD.TKGLQ...CLFVQVLQQGCLiLQSCDTGLAKPRDFVIARIGGFFELEY.....LEWqKAIYSV......GGSEMKKWPMqLR
 1664- 1872 (253.30/148.90)	SMSDGLSATSNGSSLQQPEmsmipEralpsspsPLYsPHAKPTGFMKG..SLGQPAA.RKQLMA....GHMVDNSrGLLHWAQSISfvSV.....S........MDHTLQLVL.PA.DSSPGYIEGF..TPVKSL..GS.ASSAYIL....IPSPSMRFLPP.TT.LQlptCLTAESPPLAHL.LHSKGSALPLSTGFVVSKAVPSMRKDYrsnlkEEW.PSVLSVslidyyGGTNIPQEKI.LR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.06|      15|      23|    1197|    1219|       3
---------------------------------------------------------------------------
 1197- 1215 (23.87/26.24)	PQGlgnqMEIESGKLSSCG
 1222- 1236 (27.19/ 9.03)	PQS....MKIESSNASLVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.67|      19|      28|     519|     540|       4
---------------------------------------------------------------------------
  519-  540 (30.61/23.70)	QALLSEFGDFGDFFENdvlPFG
  549-  567 (35.06/19.01)	QALMFSAPDCGDVNSS...PVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.14|      31|     274|     873|     910|       5
---------------------------------------------------------------------------
  216-  247 (51.05/24.12)	PVIV.SPHGIRGSL.VGSSPSDLVKQSYfSTSKF
  874-  906 (50.10/40.54)	PVGVwRTVGVSKPMkPSSSPNMEVGPSY.SHNSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.02|      65|     449|     299|     370|       6
---------------------------------------------------------------------------
  299-  370 (104.32/82.12)	NLSKLHVAESpaaGRSDHKGS..PDHLSDCEKTFLypAEAVLVPVLQTSLARssLRRFWL..QNWM..GPSLP.GSSSF
  757-  828 (97.71/58.04)	NIGSNAVAKS...GLKMNEGTleSEHLLLSAKTLL..ATDVMCVMFQASMCR..LRHTLLssSNIMplGFGRPtGVAFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.37|      23|      23|    1337|    1359|       7
---------------------------------------------------------------------------
 1277- 1299 (25.59/10.67)	...EGSNSScmvIYVVCPFPDPSAVL
 1337- 1359 (38.10/19.58)	TVDETSASN...ILVLSGFSIPKLVL
 1363- 1380 (27.68/12.16)	TVD.....A...IFRVTSPSVSELVI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23493 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPWAEINGSRMQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPNELEADADSLT
2) HGVSAVGSPNSDSSKTMADDGSGNYMQNTSTTGSADSASSIDGS
3) QSVVSSGDQLESDGPKLGSKRSRAGVTESLSTATNVPMQ
382
1501
438
435
1544
476










Molecular Recognition Features






MoRF SequenceStartStop




NANANA