<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23448

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQTVELSTLELSTLVSRAAQDSYSSLKELVEKCRSTELSDTDKKISILKFLGKTQQRMIRLNVLSKWCQQVHLIKHCQPLASTVSNHDMCFTQAADSLFFMHEGLQQTRAPVYDVPSAIDILLTRSYQRLPKCTEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVSMVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAEAENPFSILYSVLHNLCVSLVMDTVIRQVQALRQGRWKDAIRFELISEGGMGHAAGSSSMQNPDGESDSSGPRTPGLKIIYWLEFDKNAGMSQIKCIHSNFVIDPLTGKEAEFFLDQSCIDVERLLLRAISCNRYTRLLEIKRELGKNNQVCRAADDVVLQSHLGGPDVEYKQKDDKCFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALEDEMNLSLVDWGKLHSLLPNAACPNQQSVPGTPSPKWEGGMQISQVNNVTKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQHRVLSDSSNDVCHLDYYLLLYQLVVAYLYLIPNLMDLKLNHSRLLEPIHVLQLPYAMESTGNEDVIPKHDKRSWKRTASDMLNLIPSLRGLENNSAICKRRKILDSSGSQLSLPQGFVPTEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFAGGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVTDIQRLANARTFALGMRQLLGVKADEKSEETSSDSKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLAHMAAELGQQTVELTTLVSRAAQDSYSNLKELVEKCRSTELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIKHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRTKLLEVSLPKEISEIKVSDGTALIKVDGEFKVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAAAENPFSILYSVLHDLCVSLVMDTVIRQVQALRQGRWKDAIRFELISDAAGSMQNPDGESDSSGPRTPGLKIIYWLESDKNAGMSDSGACPFIKIEPGPDLQIKCIHSNFVIDPLTGKEAEFFLDQSCIDVERLLLRAISCNRYTRLLEIKRELEKNNHVYRAADDVVLQSHLGGPDVEYKQKDDKGFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSSLLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGSVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALKDEMNLSLVDWGKLHSLLPNAACPNQESVPGTPSPKWEGGMQTSQVNNVTKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQLRVLSDSSNDGFGGSRSSRLLSPLPTSSRISVPNSKPNGPQAESLKAAGANSCASTPAMESTGNEDVIPKHDKRSRKRTASDMLNLIPSLQGLENNSAICKRRKILDSSGSQLSLPQGVVPTEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFARGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRQLLGVRADEKSEETSSDAKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGYIQPQGLLGSSTSNVGQPTSGPGGNTAMSAPGGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPNFTAQQAGGLANSNNPNPSSSSQLMGANGSRINLPASAAMSRTGNPAAGLNRVGNALAGPSNLALMNSAVSLRRPPGAIVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSNPAQEELSQTEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQIGDMVSAQKPRIELCLENHAGLTTDDNSESSSAFRSNIHYDRNHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPSVSFLGMEGSHGGRACWLRVDDWDKCKQRVARTVEVSGSSPADASQGRLKLVADSVQRNLHMCLQGLKDGSGVPANFGAT
Length2793
PositionTail
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.06
Grand average of hydropathy-0.191
Instability index44.60
Isoelectric point7.34
Molecular weight306706.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23448
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     643.67|     135|     545|     254|     389|       1
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  254-  345 (151.98/105.15)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................VMDTVIRQVQALRQGRWKDAIRFELISEgGMGHAAGSSSMQNPDGESDSSGPRTPGLKIIYWLEF.DKNAGM.S................QIKCIHSNFVID.PLTGKEAE
  346-  389 (52.18/28.19)	FFLDQSCIDVERLLLRAISCNRYTRLLEIKRELGKNNQVCRAAD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  807-  895 (127.06/82.43)	..............................................dvvlqshlggpdveykqkddkcfskesegyevlrvrayascfftlgvnirngrfllqssqnivassalleceealnqgsmtaadvfvslrsksllhlfasigrvlglevfehgfstvkvpknilngsamlimafpdcgssyflmmeldkdfkplfklletqpdssgkdtlfgvlnqvlrvkridigqlqaledemnlslvdwgklhsllpnaacpnqqsvpgtpspkweggmqisqvnnvtkpsgvtnhysdsmfssgsvkgpvqsnsvgsistgqgrsaagkrlfvskseqdlaslksphsvdivsstamdedqhrvlsdssndvchldyylllyqlvvaylylipnlmdlklnhsrllepihvlqlpyamestgnedvipkhdkrswkrtasdmlnlipslrglennsaickrrkILDSSGSQL.SLPQG....FVPTEMISR.AEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLcIKHARLtS................QMDSLDISYVEEvGLRSASSN
 1327- 1427 (134.35/87.68)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................VMDTVIRQVQALRQGRWKDAIRFELISD.....AAG..SMQNPDGESDSSGPRTPGLKIIYWLES.DKNAGM.SdsgacpfikiepgpdlQIKCIHSNFVID.PLTGKEAE
 1428- 1471 (51.77/27.89)	FFLDQSCIDVERLLLRAISCNRYTRLLEIKRELEKNNHVYRAAD..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1891- 1979 (126.32/81.90)	............................................dvvlqshlggpdveykqkddkgfskesegyevlrvrayascfftlgvnirngrfllqssqnivassslleceealnqgsmtaadvfvslrsksllhlfasigsvlglevfehgfstvkvpknilngsamlimafpdcgssyflmmeldkdfkplfklletqpdssgkdtlfgvlnqvlrvkridigqlqalkdemnlslvdwgklhsllpnaacpnqesvpgtpspkweggmqtsqvnnvtkpsgvtnhysdsmfssgsvkgpvqsnsvgsistgqgrsaagkrlfvskseqdlaslksphsvdivsstamdedqlrvlsdssndgfggsrssrllsplptssrisvpnskpngpqaeslkaaganscastpamestgnedvipkhdkrsrkrtasdmlnlipslqglennsaickrrkILDSSGSQL.SLPQG....VVPTEMISR.AEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLcIKHARLtS................QMDSLDISYVEEvGLRSASSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    2489.87|     757|    1081|       1|    1069|       2
---------------------------------------------------------------------------
   16-  253 (283.25/182.48)	.................................................................................................................LSTLVSRAAQDSYSSLKELVEKCRSTELSDTDKKISILKFLGKTQQRMIRLNVLSKWCQQVHLIKHCQPLASTVSNHDMCFTQAADSLFFMHEGLQQTRAPVYDVPSAIDILLTRSYQRLPKCTEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVS............MVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAEAENPFSILYSVLHNLCVSL...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  390-  806 (705.89/462.75)	....................................................................................................................................................................................................................................................................................................................................................................................vmdtvirqvqalrqgrwkdairfeliseggmghaagsssmqnpdgesdssgprtpglkiiywlefdknagmsqikcihsnfvidpltgkeaeffldqscidverlllraiscnrytrlleikrelgknnqvcraadDVVLQSHLGGPDVEYKQKDDKCFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQ.............PDSSGKDTLFGVLNQVLRVKRIDIGQLQALEDEMNLSLVDWGKLHSLLPNAACPNQ.QSVPGTPS.....PKWEG.....GMQISQVNNVTK.............PSGVTNHYSDSMFSSGSVKGP..VQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQHRVLSDSSND.VCHLDYYLLLYQLVVAYLYLIPNLmdlKLN..HSRLLEPI...HVLQLPyAMESTGNEDVIPKHDKRSWKRTASDMLNLIPSLRGLENNSAICKRRK
  964- 1326 (530.02/335.02)	HYDPDGVVLSYQSVEVDSIKKLVTDIQRLANARTFALGMRQLLGVKADEKSEETSSDSKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLAHMAAElgqqtveLTTLVSRAAQDSYSNLKELVEKCRSTELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIKHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRTKLLEVSLPKEISEIKVSdgtalikvdgefKVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAAAENPFSILYSVLHDLCVSL...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1472- 1890 (695.17/442.97)	...........................................................................................................................................................................................................................................................................................................................................................................vmdtvirqvqalrqgrwkdairfelisdaagsmqnpdgesdssgprtpglkiiywlesdknagmsdsgacpfikiepgpdlqikcihsnfvidpltgkeaeffldqscidverlllraiscnrytrlleikreleknnhvyraadDVVLQSHLGGPDVEYKQKDDKGFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSSLLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGSVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQ.............PDSSGKDTLFGVLNQVLRVKRIDIGQLQALKDEMNLSLVDWGKLHSLLPNAACPNQ.ESVPGTPS.....PKWEG.....GMQTSQVNNVTK.............PSGVTNHYSDSMFSSGSVKGP..VQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQLRVLSDSSNDgFGGSRSSRLLSPLPTSSRISVPNS...KPNgpQAESLKAAganSCASTP.AMESTGNEDVIPKHDKRSRKRTASDMLNLIPSLQGLENNSAICKRRK
 2048- 2285 (275.55/159.79)	HYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRQLLGVRADEKSEETSSDAKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................wesgkegctmhvsPDQLWPHTKF..LEDF.....INGAEVSSLLDCIRLTA...GPLHAL.AAATRPARaGPVPGVAAalssiPKQTGyiqpqGLLGSSTSNVGQptsgpggntamsaPGGLTNQ.TLSMLAAAGRGGPgiVPS.............................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     361.50|      68|    1082|     896|     963|       3
---------------------------------------------------------------------------
  896-  963 (158.28/89.22)	IWFRLPFAGGDSWQHIC.LRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHI
 1980- 2047 (158.12/89.12)	IWFRLPFARGDSWQHIC.LRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHI
 2729- 2767 (45.11/20.08)	................CwLRVD.....DWD.KCKQRVARTV.EV.SGSSPADASQG.RLKLVAD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      14|      16|    2367|    2382|       4
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 2367- 2382 (21.82/16.91)	QQAGglANSNNPN.PSS
 2385- 2399 (20.86/ 9.10)	QLMG..ANGSRINlPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.59|      51|     260|    2413|    2465|       5
---------------------------------------------------------------------------
 2413- 2465 (80.96/59.77)	NRVGNALA...GPSNLALMNSAVSLRRPPgAIVPAHVR...GElNTAIIGLGDDGGYGG
 2670- 2726 (82.63/51.82)	NSVDFALTvvlDSAHIPHVNAAGGAAWLP.YCVSVRLRysfGE.SPSVSFLGMEGSHGG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23448 with Med14 domain of Kingdom Viridiplantae
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