<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23447

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQTVELSTLELSTLVSRAAQDSYSSLKELVEKCRSTELSDTDKKISILKFLGKTQQRMIRLNVLSKWCQQVHLIKHCQPLASTVSNHDMCFTQAADSLFFMHEGLQQTRAPVYDVPSAIDILLTRSYQRLPKCTEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLPKEISEIKVSMVLVTLGYRGHLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAEAENPFSILYSVLHNLCVSLVMDTVIRQVQALRQGRWKDAIRFELISEGGMGHAAGSSSMQNPDGESDSSGPRTPGLKIIYWLEFDKNAGMSQIKCIHSNFVIDPLTGKEAEFFLDQSCIDVERLLLRAISCNRYTRLLEIKRELGKNNQVCRAADDVVLQSHLGGPDVEYKQKDDKCFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALEDEMNLSLVDWGKLHSLLPNAACPNQQSVPGTPSPKWEGGMQISQVNNVTKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQHRVLSDSSNDVCHLDYYLLLYQLVVAYLYLIPNLMDLKLNHSRLLEPIHVLQLPYAMESTGNEDVIPKHDKRSRKRTASDMLNLIPSLQGLENNSAICKRRKILDSSGSQLSLPQGVVPTEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFARGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRQLLGVRADEKSEETSSDAKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGYIQPQGLLGSSTSNVGQPTSGPGGNTAMSAPGGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPNFTAQQAGGLANSNNPNPSSSSQLMGANGSRINLPASAAMSRTGNPAAGLNRVGNALAGPSNLALMNSAVSLRRPPGAIVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNSNPAQEELSQTEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQIGDMVSAQKPRIELCLENHAGLTTDDNSESSSAFRSNIHYDRNHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPSVSFLGMEGSHGGRACWLRVDDWDKCKQRVARTVEVSGSSPADASQGRLKLVADSVQRNLHMCLQGLKDGSGVPANFGAT
Length1709
PositionTail
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.07
Grand average of hydropathy-0.156
Instability index45.32
Isoelectric point7.70
Molecular weight187260.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23447
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      14|      18|    1283|    1298|       1
---------------------------------------------------------------------------
 1283- 1298 (22.20/18.28)	QQAGglANSNNPN.PSS
 1301- 1315 (21.92/10.76)	QLMG..ANGSRINlPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.54|      27|     371|    1234|    1261|       2
---------------------------------------------------------------------------
 1234- 1261 (49.15/31.66)	AGDQVWLqPATPPKEGRLSGGSLPCPQF
 1607- 1633 (51.39/28.84)	AGGAAWL.PYCVSVRLRYSFGESPSVSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.25|      30|     159|     884|     922|       3
---------------------------------------------------------------------------
  884-  922 (51.94/55.53)	VEEVGLRSassnIWFRL...PFAR.GDSWQHiclrlGRPGC.MH
 1046- 1080 (45.31/27.91)	IEAVGLMS....LWFSFgsaVLARfVVEWES.....GKEGCtMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.02|      43|     732|     923|     969|       5
---------------------------------------------------------------------------
  923-  969 (63.52/58.71)	WDvKINDQHFRDLwELqKGSSATPWGSGvRIANTAD.IDSHIHYDPDG
 1652- 1695 (72.50/45.90)	WD.KCKQRVARTV.EV.SGSSPADASQG.RLKLVADsVQRNLHMCLQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.35|      81|    1341|     169|     264|       8
---------------------------------------------------------------------------
  169-  264 (114.19/111.60)	LEVSLPKEIseikvsmvLVTLGYRGHLSMWRILHlelLVGEKnKP.IKLELMRRHVLGDDlERrmAEAENPF..SILYSVLHN...LCVSLVMDTV.IRQVQA
 1519- 1606 (121.16/79.40)	LPVSVLREF........LKLIAWKKGLSQAQIGD...MVSAQ.KPrIELCLENHAGLTTD.DN..SESSSAFrsNIHYDRNHNsvdFALTVVLDSAhIPHVNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     374.33|     123|     531|     551|     694|      10
---------------------------------------------------------------------------
  551-  694 (182.81/134.13)	PDSSGKDTLFgvLNQVlrvkrIDIGQLQALEDEMNLSlvdWGKLHSlLPNAACPNQQS.VPGTPS.....PKWEG.....GMQISQVNNVTKP.SGVTNhySDSMFSSGSVkgpvqSNSVGSISTGQGRSAAGkrlFVSKS..EQDLA.SLKSPHSVDI
 1083- 1220 (191.52/97.85)	PDQLWPHTKF..LEDF.....INGAEVSSLLDCIRLT...AGPLHA.LAAATRPARAGpVPGVAAalssiPKQTGyiqpqGLLGSSTSNVGQPtSGPGG..NTAMSAPGGL.....TNQTLSMLAAAGRGGPG...IVPSSllPIDVSvVLRGPYWIRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.30|      10|    1341|      48|      57|      11
---------------------------------------------------------------------------
   48-   57 (18.29/10.82)	KKI..SILKFLG
 1390- 1401 (14.01/ 6.59)	KKVlrGILKYLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.87|      17|      18|     386|     402|      12
---------------------------------------------------------------------------
  386-  402 (27.22/15.70)	RAADDVVLQSHLGGPDV
  405-  421 (27.65/16.07)	KQKDDKCFSKESEGYEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.09|      58|     541|     760|     836|      13
---------------------------------------------------------------------------
  760-  836 (87.79/96.80)	AMESTGNEdvipkhdkrsrkrtaSDMLNLI.PSLQGLEN....NSAICKRRkildSSGSQL.SLPQGVVPTEMISRAEGYSYG
 1317- 1380 (88.30/58.98)	AMSRTGNP...............AAGLNRVgNALAGPSNlalmNSAVSLRR....PPGAIVpAHVRGELNTAIIGLGDDGGYG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23447 with Med14 domain of Kingdom Viridiplantae
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