<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23445

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVSRAAQDSYSNLKELVEKCRSTELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIKHYQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVSDVPSAIDILLTGSYQRLPKCIEDVGTQYTLNEEQQKPALKKLDALVRSKLLEVSLTKEISEIKVSDGTALIKVDGEFKVLVTLGYRGNLSMWRILHLELLVGEKNKPIKLELMRRHVLGDDLERRMAAAENPFSILYSVLHDLCVSLVMDTVIRQVQALRQGRWKDAIRFELISEGGMGHAAGSSSMQNPDGESDSSGPRTPGLKIIYWLEFDKNAGMSDSGACPFIKIEPGPDLQIKCIHSNFVIDPLTGKEAEFFLDQNCIDVERLLLRAISCNRYTRLLEIKRELGKNNHVCRAADDVVFQSHLGGPDVEYKQKDDKCFSKESEGYEVLRVRAYASCFFTLGVNIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAADVFVSLRSKSLLHLFASIGRVLGLEVFEHGFSTVKVPKNILNGSAMLIMAFPDCGSSYFLMMELDKDFKPLFKLLETQPDSSGKDTLFGVLNQVLRVKRIDIGQLQALEDEMNLSLVDWGKLHSLLPNAACPNQQSVREFLSDIRLESSIQNAKGHPSGFSSLVDEVFGLEKGSSAYPFSVQNHGSLPSHYGSVPLNLHSLKAGTPSPKWEGGMQISQVNNVTKPSGVTNHYSDSMFSSGSVKGPVQSNSVGSISTGQGRSAAGKRLFVSKSEQDLASLKSPHSVDIVSSTAMDEDQHRVLSDSSNDGLGGSLSSRLLSPSLPTSCRISVPNSKPNGPQAESLKAAGANSCASTPICKILSFFSSTLSYNAMESTGNEDVIPKHDKRSWKRTASDMLNLIPSLRGLENNSAICKRRKILDSSGSQLSLPQGFVPTEMISRAEGYSYGSLIAEANKGNAPSSIYIAALLHVVRHCSLCIKHARLTSQMDSLDISYVEEVGLRSASSNIWFRLPFAGGDSWQHICLRLGRPGCMHWDVKINDQHFRDLWELQKGSSATPWGSGVRIANTADIDSHIHYDPDGVVLSYQSVEVDSIKKLVTDIQRLANARTFALGMRQLLGVKADEKSEETSSDSKVSGTKFASDTAEKVTEHMRKAFKIEAVGLMSLWFSFGSAVLARFVVEWESGKEGCTMHVSPDQFCPHTKFLEDFINGAEVSSLLDCIRLTAAPLHDLAAATRPARAGPVPGVAAALSSIPKQTGYIQPQGLLGSSTSNIGQPTSGPAGNTAMSAPGGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVFVVLRGQQETVCC
Length1328
PositionTail
OrganismArachis hypogaea (Peanut)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> dalbergioids sensu lato> Dalbergieae> Pterocarpus clade> Arachis.
Aromaticity0.06
Grand average of hydropathy-0.181
Instability index42.59
Isoelectric point6.73
Molecular weight144825.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23445
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      14|      16|     413|     426|       1
---------------------------------------------------------------------------
  413-  426 (25.82/13.44)	DDVVFQSHLGGPDV
  432-  445 (25.81/13.44)	DDKCFSKESEGYEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.94|      17|      18|    1232|    1248|       2
---------------------------------------------------------------------------
 1232- 1248 (29.60/18.97)	PARAGPV.P.G.VAAALSSI
 1249- 1268 (18.34/ 8.54)	PKQTGYIqPqGlLGSSTSNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.22|      40|      71|     446|     485|       4
---------------------------------------------------------------------------
  446-  485 (68.34/40.22)	LRVRAYASCFFTLGV..NIRNGRFLLQSSQNIVASSALLECE
  518-  559 (66.88/39.21)	LGLEVFEHGFSTVKVpkNILNGSAMLIMAFPDCGSSYFLMME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.10|      15|      15|    1272|    1286|      10
---------------------------------------------------------------------------
 1272- 1286 (27.05/15.67)	TSGPAGNTAMSAPGG
 1288- 1302 (25.06/13.97)	TNQTLSMLAAAGRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.00|      12|      18|     674|     685|      11
---------------------------------------------------------------------------
  674-  685 (22.15/13.74)	PFSVQN.HGSLPS
  691-  703 (16.85/ 8.37)	PLNLHSlKAGTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.50|      14|      18|     821|     834|      12
---------------------------------------------------------------------------
  821-  834 (26.74/15.87)	SCRISVPNSKPNGP
  838-  851 (23.75/13.25)	SLKAAGANSCASTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.88|      14|     814|     492|     505|      13
---------------------------------------------------------------------------
  492-  505 (24.10/14.35)	SMTAADVFVSLRSK
 1309- 1322 (24.79/14.96)	SLLPIDVFVVLRGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.49|      20|     450|     623|     659|      14
---------------------------------------------------------------------------
  282-  301 (36.06/10.34)	IRFELISEGGMGHAAGSSSM
  640-  659 (35.43/ 7.41)	IRLESSIQNAKGHPSGFSSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23445 with Med14 domain of Kingdom Viridiplantae
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