<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23398

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEHIYSSFNASFRDGSNHRFHEWLSDNRCLTSVSSSNLLAFTCVTDLKECEPKTQSINVYVIDLNIPHLPNLVTSHAEEVTSLEWDTIGSRLLIGDALGFVHIWSMKDYLINEWQLIYSHSCFLGERILASIWFHNGSKVCINPEKKDLILPYLEKFNYVKFGASVRQFGGKPVTGCMCISSSGIVSCLMLMPDGTFITGEETLGQFRAKVKVIDICYAKNGDFLVVTSNESTKSSINCYRVTVKLCTTYDKPKCNITCQQFSSFYLKCSTNDSYRLITHLKFVLKEAAEAVVVAATGLIGSTVELWELREKPVNLHKMFQTKEFGSSSLQPKTVVWQHHASITHSHTVVAIATPRQSLFDITPPLSYIVVAFRDNVIKCFYRENLQQVCSLNMSMTSIQDTSYNLQKMSNMANLTSIVDMQFTYSGCALIAMDATSQIFVYRVSPIIDPGSVYSPSFIQTLLEYCIITGNDWWDIIICLRPNIIDNVCDKLSEAFLQKQPIGFQQKWMSRFLTIKASLHRCSATNGPVKSGDCYALIWLNTISSVLKSLLRGKDHQDKDGPAEDLNALMHTRGNEIQHTNVDRVLQCIKHKEFFVEGPVLQSLQHLIQWTADFTLFLLASLPQQCHNHCLFPGGGLIFDTKSVNNLRELLVLIRIWGLINEPCLPLFTKLTSDNFDVIELLFKLLSKTVSAIGNEPDESLLDECCLLPNQVLIPQMDFTMKAIGVASPIIFINSHPLIFEYYSDAPFLKYQVKTHSIDGAVHISAGCKIDSIRHIGLGNVSDYNHNVRRCTRCTTVSLLHPFFKSAAARSWDQRWLKNCICGGNWRVQ
Length829
PositionTail
OrganismLeptotrombidium deliense
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Acariformes> Trombidiformes> Prostigmata> Anystina> Parasitengona> Trombiculoidea> Trombiculidae> Leptotrombidium.
Aromaticity0.10
Grand average of hydropathy0.023
Instability index38.78
Isoelectric point7.11
Molecular weight93586.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.81|      20|      28|      84|     104|       1
---------------------------------------------------------------------------
   84-  104 (33.66/23.52)	EWDTIGSR.LLIGDALgFVHIW
  113-  133 (35.16/19.69)	EWQLIYSHsCFLGERI.LASIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.84|      21|      35|     528|     562|       2
---------------------------------------------------------------------------
  508-  528 (39.34/39.01)	WMSRFLTIKASLHRC...SATNGP
  539-  562 (31.50/20.17)	WLNTISSVLKSLLRGkdhQDKDGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.99|      30|      35|     428|     460|       3
---------------------------------------------------------------------------
  428-  460 (45.09/40.23)	CALIAMDATSQIFVYRvSPIIDpgSV...YSPSFIQ
  466-  498 (51.90/33.95)	CIITGNDWWDIIICLR.PNIID..NVcdkLSEAFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.11|      28|      33|     211|     241|       4
---------------------------------------------------------------------------
  178-  208 (25.10/ 9.87)	.....MC..ISSSGivsclmlmpDGTFITGEE....TLGQ.....FR
  211-  241 (43.21/30.96)	VKvidIC..YAKNG.........DFLVVTSNESTKSSINC.....YR
  244-  276 (38.79/20.46)	VK...LCttYDKPK...........CNITCQQFSSFYLKCstndsYR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23398 with Med16 domain of Kingdom Metazoa
Unable to open file!