<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23390

Description Mediator of RNA polymerase II transcription subunit 15a-like protein isoform X1
SequenceMDSNDNSMAADWRTQLMPESRHLIVNKILETLKRRLPISGPEGLVELRKIAVRFEEKIYSAASSQEYLMDSYDNSMAADWRTHLMPESRHRIVNKIMETLKRHLPISGPEGLVELRKIAVRFEEKIYNAASSQSDYLRKISLKMLMMESRSNCSGNKNPPAPEEFDDVPDDDEYDTEDSFIDDAELEPISPQQPGQQQFQQSFGQLHLMTQQPQSQIPQLQQQENQVNLIEKMNIQGPATTMHSTAVSSSQQGSISLSAHVEVENGQQKMVTGFQPSSDLESASGHTLSSLPQDMVGPLQQNTIDAPHLTNNSMWSRNVIQLQHGANSLELNSIILQEQHLKQQKQEQQLKNEHEQRQVVQKLIQQQQMQRLLQLRQQQQKQQQLLQLQALAGGKTGMFPQPHLTGQHETAYPQLKIGPPCPDSSPQLLHATSLQLPQHSSLQTSPWNLPSTLPKAGTSLQFAPYPCIGTLTPTSVRPSPIPAGSKKLPSFISSIPNAGNIGHQETVHGLTKAQYLSIGTPGMLTSPLLPEFSSVAGKHGNASQNIFGKLNATERPPERLTKAVLLSLTLFLVVLIIYFTA
Length581
PositionTail
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.05
Grand average of hydropathy-0.549
Instability index67.38
Isoelectric point6.26
Molecular weight64776.64
Publications
PubMed=30626928

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23390
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.60|      65|      65|       1|      65|       1
---------------------------------------------------------------------------
    1-   65 (134.20/109.45)	MDSNDNSMAADWRTQLMPESRHLIVNKILETLKRRLPISGPEGLVELRKIAVRFEEKIYSAASSQ
   69-  133 (137.40/112.26)	MDSYDNSMAADWRTHLMPESRHRIVNKIMETLKRHLPISGPEGLVELRKIAVRFEEKIYNAASSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.61|      47|      47|     472|     518|       3
---------------------------------------------------------------------------
  421-  468 (54.19/25.14)	CPDS.SPQLLHATSLQLPQHSslqtspwnlpSTLPKA...........G.........tsLQFAPYPCI
  472-  518 (86.35/44.07)	TPTSVRPSPIPAGSKKLPSFI..........SSIPNAGNIGH.QETVHG...........LTKAQYLSI
  520-  568 (50.07/22.72)	TPGML.TSP......LLPEF...........SSV..AGKHGNaSQNIFGklnaterpperLTKAVLLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.43|      27|      29|     335|     361|       4
---------------------------------------------------------------------------
  210-  231 (22.00/ 7.90)	.......T...QQPQSQipQLQQQENQVNLIE
  335-  361 (45.31/25.75)	ILQEQHLK...QQKQEQ..QLKNEHEQRQVVQ
  363-  387 (31.12/14.88)	LIQQQQMQrllQLRQQQ..Q...K..QQQLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.02|      18|      92|     293|     310|       5
---------------------------------------------------------------------------
  235-  254 (22.27/ 9.42)	IQGPATT..........mhSTAVSSSQQGS
  304-  333 (19.76/ 7.62)	IDAPHLTnnsmwsrnviqlQHGANSLELNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.70|      24|     125|     272|     298|       6
---------------------------------------------------------------------------
  272-  298 (40.14/28.41)	TGFQPSSDLesaSGHTLSSLPQDMVGP
  396-  419 (46.57/25.90)	TGMFPQPHL...TGQHETAYPQLKIGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23390 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESRSNCSGNKNPPAPEEFDDVPDDDEYDTEDSFIDDAELEPISPQQPGQQQFQQSFGQLHLMTQQPQSQIPQLQQQENQVNLIEKMNIQGPATTMHSTAVSSSQQGSISLSAHVEVENGQQKMVTGFQPSSDLESASGHTLSSLPQDMVGPLQQNTIDAPHLTNNSMWSRN
2) TGMFPQPHLTGQHETAYPQLKIGPPCPDSSPQLLHATSLQLP
148
396
318
437










Molecular Recognition Features






MoRF SequenceStartStop




NANANA