<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23387

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQEAVEFSTLVRRAAEDSFLSLKELVEKSKSSEQSDSEKKISLLKYIVKTRQRMLRLHVLAKWCQQVPLVQYCQQLAATLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIDVLLTGNYQRLPKCIEDMGSQSTLTEEEQVPTLKKLDTLLRSKLLEASLPKEISKVTVSDGTALLCVDGEFKVLLTLGYRGHLSMWRILHMELLVGEKCGPVKLEEMRRHALGDDLERRMAASDNPFMILYSILHELCVALIMDTVLRQVRALRQGRWKDAIRFELISEGTTGQGVNAGSMQLNQDGDSDSTGLKMPALKIMYWLDFDKNTAGSDSTSSPFIKIESGQDLQIKCIHSAFVVDPQTGKEAEFSLDQSCIDVENLLLRAIACNKHTRLLEIHKELSKNAQICQAAGDVILKCHGDESDSDSRQDSKSSTGGYGVDEVLLVRAYGLSYITLKINIRSGRFLLQSSRNILASSAILDCEEALNQGSMNAADVFVNLRRKSMLHLFASIGRFLGFKVYEQGSTAVKIPKIIVNGSDLLLMGFPHHGSSYYLLIQLDKDFKPLFKLLETQPDLCGRSLSAGDSNQVIRFNKIDISQMQMVEDELNLSLLDWEKLFSPLPNGGDPNQTSEISLLPEYGQESTAQMLECSQSSFSSVIDEVFEFEKGDLMPSFPIQSQPPSSFSMSSMSHLGSLPTSRQMMKTGMASLKWDGGLQLSQISSTIKGSSVGSPLNSSLYPSNNTKGLIQPSHASSLSSSPVRSPSIQKLTASKSEQELTSLRSPSHSLDIGPMDEDQVRLLKGSPKEAVPVAAGSRSAQLLSPLRTTGGRVSSASIKPNVLKSACSGPLVSSVRNAGSGPLTTSAICQTTESGSNNHSLSYDAVPKHDKNSKKRSLSEVLKLIPSLQGVECGTGPRKKRNISDSAQYYNTTSQSHLSLGTCRTDGCTYGNILAEANHGRAPSSIYITSFLHVVRHCSLCIKHAQLTSQMDSLDIPYVEEVGFRNPSSNLWFRLPFARDDSWRHICLRLGRPGSVYWDVKVNDQHFRELWELQKGSTGTPWGSGVRTANTSDVDSHIRYDPEGVVLSYKTVEADSIQKLVADLQRLSNARSFALGMRKLLGVRADDKSEDGSPSSGVKGVGEVADKMSEQIRRAFRIEAVGLMSLWFSFGSVPGIVARFVVEWEAGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLLALAGAIRPARSGPVSSGVHGFAPGLSTAPKQNNFIPSQGLLPNGLSSNANQPASAAPIGNPAVSTVMGPLGNHSLHSAAMLSVAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFSVDMRCFAGDQVWLQPATPAKSDPDGGGSLPCPQFRPFIMEHVAQGLSALEPNFTGAAHAVGLMSSSNPNIGSGSQLPVTNANRATVSGGVSRPTSMVGNQGGNLTRVSSPMLASASLAAASSGLPLRISAGVPLHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPGLLKEILGSNLTNNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHSQQQSQPNIPQEELAPTEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVVQGGEIAPSQRPRIELCLENHAGYAADENSENSSTSKSNIHYDRPHNLVDFGLTVVLDPAHIPNIIAAGGAAWLPYCVSVRLRYTFGENTPHISLLGMEGSHGGRACWLRVEDWEKCKQRVARAVEFGSGNSAGDTGQGGKLRVVAEALQRTLQLLLQQLRENSTNPVAS
Length1829
PositionTail
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.06
Grand average of hydropathy-0.169
Instability index50.02
Isoelectric point7.39
Molecular weight198604.06
Publications
PubMed=30626928

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23387
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.74|      17|      18|     671|     688|       3
---------------------------------------------------------------------------
  671-  688 (27.69/17.50)	MPSFPIQSQPPSSfSMSS
  692-  708 (30.05/14.37)	LGSLPTSRQMMKT.GMAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.94|      17|      18|    1502|    1519|       4
---------------------------------------------------------------------------
 1502- 1519 (25.44/19.84)	GGGWVpLAALKKVLRGIL
 1523- 1539 (30.50/18.14)	GVLWL.FAQLPGLLKEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.10|      27|     182|     185|     212|       5
---------------------------------------------------------------------------
  185-  212 (44.54/34.56)	CVDGEFKVLLTLGYRGHLSMWRIlHMEL
  353-  372 (25.14/12.87)	CIHSAFVVDPQTGKEAEFSL........
  376-  402 (43.42/28.62)	CIDVENLLLRAIACNKHTRLLEI.HKEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.72|      12|      17|    1305|    1317|       6
---------------------------------------------------------------------------
 1305- 1317 (17.39/16.26)	SAAM...LSVAGRgGP
 1322- 1336 (15.33/ 7.05)	SSLLpidVSVVLR.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.84|      27|     181|     432|     482|       8
---------------------------------------------------------------------------
  432-  467 (30.44/66.40)	SKSSTGGYgvdeVLLVRAyglSYITLKINIrsGRFL
  491-  517 (47.40/23.12)	SMNAADVF....VNLRRK...SMLHLFASI..GRFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.56|      17|      17|    1123|    1139|       9
---------------------------------------------------------------------------
 1123- 1139 (29.11/18.45)	DDKSEDGSPSSGVKGVG
 1143- 1159 (28.45/17.83)	DKMSEQIRRAFRIEAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      15|      16|     864|     879|      10
---------------------------------------------------------------------------
  864-  879 (20.68/17.54)	AIcQTTESGSNNHSLS
  882-  896 (25.24/14.84)	AV.PKHDKNSKKRSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.02|      22|      23|    1017|    1039|      11
---------------------------------------------------------------------------
 1017- 1039 (39.98/25.97)	DDSWRHI.CLRLGRPGSvYWDVKV
 1041- 1063 (36.04/18.95)	DQHFRELwELQKGSTGT.PWGSGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      16|      18|     774|     789|      12
---------------------------------------------------------------------------
  774-  789 (27.13/15.35)	EQELTSLR.SPSHSLDI
  794-  810 (21.19/10.22)	EDQVRLLKgSPKEAVPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.73|      59|     259|    1440|    1501|      15
---------------------------------------------------------------------------
  827-  862 (47.20/22.19)	.........GG...RVSSASIKPNVLKSACSG..PL.VSS.VRNAGS.GPLTT............
 1440- 1501 (92.28/63.99)	RPTSMVgNQGGnLTRVSSPMLASASLAAASSG.LPLRISAgVPLHVK.GELNTAFIG.LGDDGGY
 1703- 1761 (89.25/49.47)	RPHNLV.DFG..LTVVLDPAHIPNIIAAGGAAwLPYCVS..VRLRYTfGE.NTPHISlLGMEGSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.86|      34|     484|     724|     757|      17
---------------------------------------------------------------------------
  724-  757 (58.55/37.64)	IKGSSVGSPLNS...SLYPSNNTKGLIQPSHASSLSS
 1208- 1244 (52.31/32.66)	INGAEVASLLDCirlTAGPLLALAGAIRPARSGPVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.91|      35|    1453|     139|     175|      18
---------------------------------------------------------------------------
  139-  175 (50.45/34.37)	SQSTLTEEEQVPT.LKKLDTLLRSKLleASLPKEISKV
 1594- 1629 (57.47/33.71)	SQPNIPQEELAPTeISEICDYFSRRV..ASEPYDASRV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23387 with Med14 domain of Kingdom Viridiplantae
Unable to open file!