<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23380

Description Cyclin-dependent kinase E-1-like protein isoform X1
SequenceMGDGSSSSSSSSRPAWLQQYDLVGKIGEGTYGLVFLAKSKLPSNKGKCIAIKKFKHSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINHVDMSLYLAFDYAEHDLYEIIRHHREKVNHSMNLYTIKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGDEQGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGGKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKAQANPFQLDQLDKIFKVLGHPTPEKWPTLVNLPHWLQDQQHIQQRKYDNPGLFSVVHLPPKSPAYDLLSKMLEYDPRKRITAAQALEHEYFRMEPLPGRNALVPSPLVEKAVNYPARPVDTTTDFEGTTSVQPSQQATGNTVSGSVASMVPARPVPRSMPLVGMQRMPAGGMAAFNLASQAGMGNLNPAAIPMQRGSQAHQQQLRRKDPGGMGMNTGYPQQKSRRF
Length465
PositionKinase
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.08
Grand average of hydropathy-0.332
Instability index43.49
Isoelectric point9.32
Molecular weight51778.98
Publications
PubMed=30626928

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23380
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.20|      29|      35|     354|     388|       1
---------------------------------------------------------------------------
  354-  382 (50.76/39.10)	PARPVDTTTDFEGTTSVQPSQQATGNTVS
  390-  418 (53.44/28.27)	PARPVPRSMPLVGMQRMPAGGMAAFNLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.87|      35|      35|     264|     298|       2
---------------------------------------------------------------------------
  264-  298 (66.04/44.11)	KWPTLVNLPHWLQ.D.QQHIQQRKYDNPGLFSVVHLP
  300-  336 (50.83/32.42)	KSPAYDLLSKMLEyDpRKRITAAQALEHEYFRMEPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.73|      28|      42|     158|     187|       3
---------------------------------------------------------------------------
  158-  187 (43.90/35.85)	LVMGEGDEQGVVKIADFGLarIYQA..PLKPL
  203-  232 (45.84/30.74)	LLLGGKHYTSAVDMWAVGC..IFAEllTLKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.26|      12|      26|     421|     434|       4
---------------------------------------------------------------------------
  421-  434 (14.80/17.37)	GMGnLNpAAIPMQR
  450-  461 (25.46/15.03)	GMG.MN.TGYPQQK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23380 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKAVNYPARPVDTTTDFEGTTSVQPSQQATGNTVSGSVASMVPARPVPRSMPLVGMQR
2) MGNLNPAAIPMQRGSQAHQQQLRRKDPGGMGMNTGYPQQKSRRF
348
422
405
465










Molecular Recognition Features






MoRF SequenceStartStop




1) GMNTGYPQQKSRRF
2) LRRKDP
3) PAWLQQYDL
452
443
14
465
448
22