<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23313

Description Mediator of RNA polymerase II transcription subunit 16 isoform X1
SequenceMEEDPASPATVFKIRLRQHRSNLRHKMSVPELCRNFSAVTWCGRLNTIACASETCARIPSSNANPPFWIPIHIVNPERPTECAIFNVIADSPRDSVQFMEWSPAPCPRALLIANFHGRITIWTQPSQGPVNLVRDASCWHCEHEWRQDLAVVTKWLAGMCPYRWLSSSSSTVANSKLTFEDKFLPQLPQTSARWPNFLCVCSVFSSGSVQLHWSQWPPAQSDATPKWFSTSKGLLGAGPSGIMAADAIITEAGTLHVAGVPIVNPSTVVVWEVMPGPGNSFQAVAKTNTGNGVSSPLNPPSWTGFAPLAAYLFSWQEYLGTGGKQGTKQADQVFNETVPLHCSPVSNFSAYVSPEAAAQSGATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQCWESSLQPVVLHQIFASHSSSFGGQPPMQTVWSSRVNKSIPLMSNSKFCQSAATASTLTDEQNLSDSSAVKANRLSFDPYDLPSDVRALAQIVYSAHGGEVAVAFLRGGVHIFSGANFAPVDSYLINVGSAIAAPAFSSNGCCLASVWHETTKDRTVLKIIRVLPPAAINIQMKVFATWERAIADRFWWSLLVGVDWWDAVGCAQSAAEDGIVSLNSVIALLDADFHSLPSTQHRQQYGPSLDRIKCRLLEGTNAQDVRALVLDMQARLLLDMLGKGIESALVNPGTLIPEPWHVSGETLSSIDPESMTIEPALVSSIQAYVDAILDLASHFITRLRRYASFCRTLASHAVGPSAGGGSARSMVTSPTHSSATLTSQGAQTGPASSSGTSQMQAWVQGAIAKISSNSDGTSSTPNPISGPSTPFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFFFRKKQLRLMGGAQRNPDSNLQKNQPGIGGKVEETNTVTTRPTASGIVRSEEGQGGRSGQVPGAKGLEEGPAVRQFRLGSGNAGQGYTSEEVRVLFLILVDLCRRTSPLAHPLPVSQVGASNIIIRLHYIDGNYTVLPEVVEAALGPHMQNMPRPRGADAAGLLLRELELHPPSEEWHRRNMYGGPWSDPEDTGLTDEPPNPKPSSSFDIQFNASGDHEDYSGAQALWPRKRRLSERDAAFGLKTSVGLGAYLGIMGSRRDVVTAVWKTGLDGVWFKCIRCLRQTSAFALPGAPDAASTLNEREAWWISRWAHGCPMCGGTWVRVV
Length1197
PositionTail
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.08
Grand average of hydropathy-0.125
Instability index44.90
Isoelectric point6.86
Molecular weight129227.92
Publications
PubMed=30626928

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23313
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      15|      28|     787|     801|       1
---------------------------------------------------------------------------
  787-  801 (26.35/10.77)	SQGAQTGPASSSGTS
  818-  832 (27.38/11.48)	SDGTSSTPNPISGPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.80|      13|      14|     912|     924|       2
---------------------------------------------------------------------------
  912-  924 (22.47/12.70)	RP.TASGIVRSEEG
  928-  941 (18.32/ 8.90)	RSgQVPGAKGLEEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.92|      22|     171|     367|     390|       3
---------------------------------------------------------------------------
  367-  390 (31.59/18.75)	GSGVTAVAFdpTRGGSVIAVVIVE
  540-  561 (40.33/17.94)	GSAIAAPAF..SSNGCCLASVWHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.09|      28|     171|     496|     523|       4
---------------------------------------------------------------------------
  496-  523 (45.51/31.65)	DVRAL.....AQIVYSAHGGEVAVAFLRGGVHI
  649-  667 (21.59/10.78)	..............YGPSLDRIKCRLLEGTNAQ
  668-  700 (36.99/24.21)	DVRALvldmqARLLLDMLGKGIESALVNPGTLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     355.05|      93|     146|     261|     354|       6
---------------------------------------------------------------------------
  217-  258 (40.56/15.24)	......................................PPAQSDATP...KWFSTSKGLLGAGPSGIMAADAIITEAGTLHVA...........
  261-  354 (160.07/87.54)	PIVNPSTVVVWEVMPGPGNSFQAVAKTNTGNGVSSPLNPPSWTGFAPLAAYLFSWQEYLGTGGKQGTKQADQVFNETVPLHCSPVSnFSAYVSP
  403-  494 (154.43/80.69)	PSITGWRVQCWESSLQPVVLHQIFASHSSSFGGQPPMQ.TVWSSRVNKSIPLMSNSKFCQSAATASTLTDEQNLSDSSAVKANRLS.FDPYDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.25|      23|     529|     592|     619|       7
---------------------------------------------------------------------------
  592-  614 (47.15/22.25)	RAIADR.FWWSLLVGVDWWDAVGC
 1131- 1152 (40.25/17.23)	RDVVTA.VWKTGLDGV.WFKCIRC
 1169- 1186 (29.85/14.26)	STLNEReAWW.....ISRW.AHGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.90|      13|     113|     742|     754|       8
---------------------------------------------------------------------------
  742-  754 (26.05/20.61)	HFITRLRRYASFC
  858-  870 (26.85/21.50)	HFLHRLCQLLLFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.31|      21|     342|     701|     723|       9
---------------------------------------------------------------------------
  701-  723 (39.19/22.55)	P..EPWH...VSGETLSsiDPE..SMTIEP
 1043- 1070 (33.12/13.84)	PpsEEWHrrnMYGGPWS..DPEdtGLTDEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23313 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAQRNPDSNLQKNQPGIGGKVEETNTVTTRPTASGIVRSEEGQGGRSGQVPGAKG
2) GGGSARSMVTSPTHSSATLTSQGAQTGPASSSGTS
3) RRNMYGGPWSDPEDTGLTDEPPNPKPSSSFDIQF
883
767
1050
937
801
1083










Molecular Recognition Features






MoRF SequenceStartStop




1) VFKIRLR
11
17