<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23307

Description Mediator of RNA polymerase II transcription subunit 15a isoform X1
SequenceMDANNNNDNMDSSVDWRTQLQPNYRPRIIEKLLETLKRHILASPEELVGVASKLEEKIYSVAANRHDYLRKISLKMMTLDSKSLNGADNSIPSNYVGNQNPSDPAIQGLHSQLCNPGQSLPMGNQSQPRQQLLPQNLQNAIASSSVQSPSSLQTALSSMTGLTQTAMSNVVSQNSNLQAMSGISQNSINNSVGQGVPSNMFSNAQSHMQGRQHSQQVLSQQQQQQSQNPQQFYQHHTVNQKLQQGIMQPPLLQSHMHQHPSLLQPNQMQPSQQSHMQMSSTLQSSQATFKQIQPSMVQSAPQSSLIQNQQSSVQQPRPSGLQQHQQSVLRQQQPHQPSVHQQTSVLHQQQTPINQQPILPSQQQQQLVAQEYSATNMQQNQLLAQQNSILDMKHQQHQQKMMLSQQNNLSNVQQQQLFNQQNKNLHQQQQLSQQSNFSGQQQQQQQHLIGSQPGLGASSMQQRQHPENILQQTKGAAQQQPQQTSSALLPSQGQQSQSQPVQQLSSQSQPVQLQQHQHTLQQRIQTSASLDFTAQAGQPGAADLQEEIYQKIKSMKELYLPELTELHQKITMRCQQLEALPQHPKQTDAIEKLKSFKISLDRMISFLQFPKSSILPTYKEKLPQLEKQIINYLAKNGCTKPAASQQPGHQQLQQSVGQPHLLMQQPQSQIHQLQQQENQVSPMQPMSMQDSMTSMQTTAVSSLQSGSMPLSNYMGVPATQQNMINSLQTSSNLESTVGHTLRSLPQGALGSLQQNTINAPHKTNTGTLSHSTMNQLQPSVNSLPLNSSILQQHLKQQQQEHQLMQSQQLKQQCQQQQQRHLFQFIQQQHKQQVFQRQQQPQMQQRFQQQQLYQQQKQLQAQQIPQLHQMNEVNELKVRPGAGIKSELFPQPHHAGQRQTTYQQQLKTGSPFSVSSPQLLQAASPQLSQHSSPQIDQQNLHTAPSKVGTPLQSANSPLIGTSPSTPSAPSPIPGDSEKQSCFISSTPNARNTGHQQGAHGPTQAQSLSIGTPGISASPLLEEFTSLDGNQGNVPSNLSGKSSTMEQPLERLIKVVRSISLKAFSSSVIDIGSVVSMIDTIAGSAPGNGSRAAAGEDLVAMTKGHLQARNFISHDGSCTTKKKRLRASAMPLHAVSSACSANDSFESDLENSELESTATTRIRRHRAEVNNALLQEVREINQRLIDTNIEISDEDVDSIASAAEGEGTIVKCSFNALAATSNLKSQYASAQIFPILPLRLFVPANYPNCSPIILDKLPKEPSKEFGDLSVKARLRFSISLRGLLQPMSLGEMTQTWDDCARMVIAEYAQQSGGGSFSSRYGTWENCVRA
Length1327
PositionTail
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.03
Grand average of hydropathy-0.748
Instability index71.68
Isoelectric point9.07
Molecular weight147017.74
Publications
PubMed=30626928

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23307
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      15|      17|     248|     264|       1
---------------------------------------------------------------------------
  248-  264 (20.15/10.35)	QPPlLQSHMhQHPSLLQ
  269-  283 (27.35/ 7.04)	QPS.QQSHM.QMSSTLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     339.31|      48|      48|     376|     423|       3
---------------------------------------------------------------------------
  362-  394 (48.82/11.42)	QQQQQ......LVA..QEY.S..........................AT...NMQ...QNQLLAQQ....NSILDMKH
  395-  441 (75.10/23.42)	QQHQQKM....MLS..QQN.NL..........SNVQQ.QQLFN.Q.QNK...NLH...QQQQLSQQ.....SNFSGQQ
  442-  481 (44.19/ 9.30)	QQQQQHL....IGS..QPGlGA..........SSMQQ.RQ....H.PEN...ILQ...QTKGAAQQ..........QP
  482-  534 (43.06/ 8.79)	QQTSSAL....LPS..QGQ.Q...........SQSQPvQQLSS.QsQPV...QLQ...QHQHTLQQriqtSASLDFTA
  650-  695 (42.82/ 8.68)	QQLQQSVgqphLLM..QQP.Q...........SQIHQ.LQ....Q.QENqvsPMQ...P...MSMQ....DSMTSM..
  762-  813 (41.08/ 7.88)	KTNTGTL....SHS..TMN.QLqpsvnslplnSSILQ.QHLKQ.Q.Q.......Q...EHQLMQSQ....Q..LKQQC
  814-  857 (44.25/ 9.33)	QQQQQRH....LFQfiQQQ................HK.QQVFQrQ.QQP...QMQqrfQQQQLYQQ....Q.....KQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     145.16|      22|      22|     152|     173|       4
---------------------------------------------------------------------------
  106-  127 (30.01/10.62)	IQGLHSQLCNPGQSlPMGN.QSQ
  128-  149 (23.17/ 6.20)	PRQQLLP.QNLQNAiASSSVQSP
  152-  173 (35.65/14.27)	LQTALSSMTGLTQT.AMSNVVSQ
  177-  194 (25.50/ 7.70)	LQ....AMSGISQN.SINNSVGQ
  201-  220 (30.83/11.16)	FSNAQSHMQG.RQH.S.QQVLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.31|      13|      15|     547|     560|       5
---------------------------------------------------------------------------
  547-  560 (18.15/14.80)	EIYQKIkSMKELYL
  565-  577 (23.16/13.67)	ELHQKI.TMRCQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     200.19|      37|      39|     896|     932|       6
---------------------------------------------------------------------------
  696-  731 (25.42/ 6.66)	..QTTA..VSSLQS.....GSmPL.SnyMG.VPATQ.........QNmiNSL.QTSS....
  896-  932 (68.54/32.56)	QRQTTY..QQQLKT.....GS.PF.S..VS.SPQLL.........QA..ASP.QLSQHSSP
  933-  970 (38.21/14.34)	Q.....idQQNLHTapskvGT.PLqS..AN.SP.LI..........G..TSP.STPSAPSP
  975- 1001 (40.85/15.92)	SEK.....Q...........S.CF.I..SS.TPN.A.........RN..TGH.QQGAHGPT
 1002- 1041 (27.17/ 7.70)	Q.......AQSLSI.....GT.P..G..ISaSP.LLeeftsldgnQG..NVPsNLSGKSS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      39|     293|     316|       7
---------------------------------------------------------------------------
  286-  309 (40.48/13.23)	QATFKQI................QPSMVQSAPQSSLIQNQ
  310-  349 (33.58/ 9.69)	QSSVQQPrpsglqqhqqsvlrqqQPHQPSVHQQTSVLHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.24|      16|      18|    1101|    1116|      10
---------------------------------------------------------------------------
 1101- 1116 (30.52/22.42)	KGHLQARNFISHDGS..C
 1120- 1137 (23.72/15.56)	KKRLRASAMPLHAVSsaC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.79|      25|     632|     596|     624|      12
---------------------------------------------------------------------------
  588-  615 (36.09/27.46)	DAIEKLKSFKislDRMISFL.....QFPKSSIL
  617-  646 (34.70/23.98)	TYKEKLPQLE...KQIINYLakngcTKPAASQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23307 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CTKPAASQQPGHQQLQQSVGQPHLLMQQPQSQIHQLQQQENQVSPMQPMSMQDSMTSMQTTAVSSLQSGSMPLSNYMGVPATQQNMINSLQTSSNLESTVGHTLRSLPQGALGSLQQNTINAPHKTNTGTLSHSTMNQLQPSVNSLPLNSSILQQHLKQQQQEHQLMQSQQLK
2) NMQQNQLLAQQNSILDMKHQQHQQKMMLSQQNNLSNVQQQQLFNQQNKNLHQQQQLSQQSNFSGQQQQQQQHLIGSQPGLGASSMQQRQHPENILQQTKGAAQQQPQQTSSALLPSQGQQSQSQPVQQLSSQSQPVQLQQHQHTL
3) QIPQLHQMNEVNELKVRPGAGIKSELFPQPHHAGQRQTTYQQQLKTGSPFSVSSPQLLQAASPQLSQHSSPQIDQQNLHTAPSKVGTPLQSANSPLIGTSPSTPSAPSPIPGDSEKQSCFISSTPNARNTGHQQGAHGPTQAQSLSIGTPG
4) SLNGADNSIPSNYVGNQNPSDPAIQGLHSQLCNPGQSLPMGNQSQPRQQLLPQNLQNAIASSSVQSPSSLQTALSSM
5) TQTAMSNVVSQNSNLQAMSGISQNSINNSVGQGVPSNMFSNAQSHMQGRQHSQQVLSQQQQQQSQNPQQFYQHHTVNQKLQQGIMQPPLLQSHMHQHPSLLQPNQMQPSQQSHMQMSSTLQSSQATFKQIQPSMVQSAPQSSLIQNQQSSVQQPRPSGLQQHQQSVLRQQQPHQPSVHQQTSVLHQQQTPINQQPILPSQQQQQLVAQE
638
376
862
83
163
810
520
1012
159
371










Molecular Recognition Features






MoRF SequenceStartStop




NANANA