<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23297

Description Mediator of RNA polymerase II transcription subunit 12-like protein isoform X1
SequenceMQRFSAASYGGGVNNSAVGGTSSRDTARADSSFSSSNFSLSSRRSLPLTPYKLKCDKESLNCRLGPPDYYPQTSNCPEETLTREYLQVGYKEIVEGIEESKETALSYVASLTTDDIVKCKEAIRRRLRAINESRAQKRKAGQVYGVPLSGPLLNKSGVFPEQRNCGEDFRKKWIEGLSQHHKRLHSLAEHVPHGFRKKHLFEVLIRHNVPLLRATWFIKVTYLNQVRPTSSSVSSGTPDRTLLARTELWTKDVIEYLQCLLEEYTSTSLSYGRDQSSQTLLVSSAQHKGGSLPVIADGEEPTLQFKWRYMVRILQWHQAEGLLFCSHIIEWVLSQLQGKESVDVLQLLLPIVFNVIDSIALSQTYVRMLVEIAVHSIQSLSQASPADAVDNSRKPYVLSVLVEMIRYLILAVPDTFVALDCFPLPSSVVPDFINGRNFLLVGLEKYQYGPQEISNIYNGKGHDAFHRYMSFGYVVSSLQRRAANLALAVSPGSQGHGVVKVVQALDGVLTLGDVRVAYTSLFENLFDGGVEEGWIAEVSPSLRSSLKWIGTVSPSVVCSVFLLCEWATCDFRDCRTALPHDLKFTGRKDFSQVYIAVLLLKLRREDMHRSLQSRTGNNFPGDAFAKGSSLHDSGSAGTTIDNASEFRNGLKNSEESEGTKDILQSPGPLHDIVVCWLDQHEASREGFKRLQMLIVELIRFGIFYPQAYVRQLIVSGLMDRNGSPVDLDRQKRHYRILKQLPGSYLFDALKEAKIADASHLFEAVRIYSNERRLVLNGLLSGHPSYLKAANGSSFNFDLKKQRDNATAGRDSASPATLDHRKKSHLACSPLPIKHEKRKGKVEELKGAIAILLHFPSICSASIDGHADESQVSLKRSVGSLVTKIDTTDGTPGCEECRRAKRQKGSEDRNNLLQGVLPNPSDEEDTWWVRKGPKPLDTPKVDPPLKPTKPPSRGRRKTQSLAHLASARIEGSQGASTSHVCDNKINCPHHRTGMEGETSKSMDGNKSLHLSDVVNIGKALKQLRLLERRYITLWLIASVRQLVEGDEKAVAKVSQCTSPFSPIDDGSSVRWRLGEDELSFILYLLDVSSDLFSAVKFLLWLLPKALPSPNSGVHGGRNILVPNRNSESNVCEVREAFLLSSIRRYENILIAADLLPEALSAAMLRALAVMISNGRASLSTAFIYGRHLLKKFGSVASVAKWEKSFKSSCDQRLLSELETGRPLDSELGFSLVGVAAGVEDVDDYFRQRITARTRTAPTMKERVHKHVEEAVHYFCGKERKPFVATAPKGSCGIEKRDDAFQIAHQIVLDCVRQNGGAAQEWDPSVVASAISAIVGNVGQVVATLLDTAAGSYPPTISSLGCARHVVRIHINSLCLLKEALGERQSRVFEVALATEASSAVSAYTSGKAPHNQFQLSPETHDSSANMSNEILNGPAKMFIGRAAKIAAAVSAVVIGAVVHGVASLERMITVLRLKEGLDILQFIRGVRSSSNGISRSIGAFKSENGIEVCLHWFRLLVGDCRAVSDGLVVELLGETYVLALSRMQRMLPLNLVLPPAYSIFTMVIWRSYFNTNTANREDIQMYQSLSLAIIRHQPFRDVCLRDSHTLYDLLVSDVGDSEFAAMRELHSPVKNLKTTALVPLRARLFLNAILDCRLPQFPLMQDDGAWVPGHGDSKVYAGNEKPRDQLVHVLDSLQLAKFHWQWIELRLILNERVLIEKIETQNMSLVEAVRSLSPNAENDELCECENNFTKIVLTRLPVRPDAAPLYSEVIHLFGRMFEESLLLNAKWFLAGSDVLLGRKSITQRLTNVAQQGGFSTKVQFWKPWGWSSSVADQSAHRGEKRKLEATSLEEGEVVEEGTDVKRLGRSSAQMFDVEGFSSSKLYVTEKALAELVLPCMDQSSNESRNTFASELIKQMNTIEQQISMLTRGATKQAGPAPSGVEGAAIKNSTRKGIRGGSPGLSRRPTGVADSAPPSAAALRASMWLRLQFILRLLPVIYADREPSSRNMRHMLASVLLRLLGTRVVHEDADHSFFPVLRNSLSRREVEPLIDVSVATPLDLSGDSLFDWFLCVLHGLLSSCKPSWLKPKSTSKSTVKSPRDFSVFEREAAESLQTDLDRMQLPTAIRRRLQAAIPVLPPSLPPSISCQPPLLSSAALASMQSSLPSPGFQAGNSNPPQRSPVPSARTSSNASAKSRPLQSQDPDVEIDPWMLLEDGTGSVPVSGNSNVSVGSDHANLKACSWLKGAIRVRRTDLTYIGTVDDDS
Length2261
PositionKinase
OrganismCinnamomum micranthum f. kanehirae
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Magnoliidae> Laurales> Lauraceae> Cinnamomum.
Aromaticity0.07
Grand average of hydropathy-0.217
Instability index50.69
Isoelectric point8.78
Molecular weight249694.16
Publications
PubMed=30626928

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     341.64|      88|     610|    1005|    1136|       1
---------------------------------------------------------------------------
  366-  439 (113.95/46.82)	VRMLVEIAVHSIQSLSQ.ASPADAVDNSRK.PYVLS.VLVEMIRYLILAVPDTFVALDC..FPLPSSV.VPD.FING.RNFL.........
 1038- 1127 (141.37/125.18)	VRQLVEGDEKAVAKVSQcTSPFSPIDDGSSVRWRLGEDELSFILYLLDVSSDLFSAVKFLLWLLPKALpSPNSGVHGGRNILVPNRN.SES
 2048- 2109 (86.32/30.49)	........................IDVSVATPLDLSGDSL.F.DWFLCVLHGLLSSCK.PSWLKPKS..TSKSTVKSPRDFSVFEREaAES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     365.61|     121|     473|    1379|    1514|       2
---------------------------------------------------------------------------
 1379- 1514 (170.04/147.59)	LGERQSRVFEValatEASSAVSAYTSGKAphnQFQLSPETHDSSanmSNEILNGPAKMFIGRAAKIAAAVSAVVIGAVVH.GVA..SLERMITVLRLKEGldILQFIRGVRSSSNGISRSigAFKSENGIEVCLhWFRL
 1862- 1985 (195.56/124.88)	LGRSSAQMFDV....EGFSSSKLYVTEKA...LAELVLPCMDQS...SNESRNTFASELIKQMNTIEQQISMLTRGATKQaGPApsGVEGAAIKNSTRKG..IRGGSPGLSRRPTGVADS..APPSAAALRASM.WLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.52|      13|     474|     483|     495|       6
---------------------------------------------------------------------------
  483-  495 (23.64/14.82)	ANLALAVSPGSQG
  961-  973 (23.88/15.07)	AHLASARIEGSQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.06|      19|    1997|     111|     129|       9
---------------------------------------------------------------------------
  111-  129 (34.27/25.11)	LTTD.DIVKCKEAIRRRLRA
 2110- 2129 (30.79/21.68)	LQTDlDRMQLPTAIRRRLQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23297 with Med12 domain of Kingdom Viridiplantae
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