<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23276

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMWEEVGSVDLEKEDVLVVAWLHSGSQIVFNPETSNIVNYNEKFTRAKMSPSFTQFGKKPVDGWIAVTSIGMVHVGLLLEQGSSSMLTAKACLGQTNTHITQADVAFTADGQLLVVTSDGNVASSIHCYLVRIALKNHICSVQSTPSASFFLKRQPMPEGITQEPRLTRLSFLSRENSEVLLACWGTASFSCIEAWHLLDQTIPLNRMFQNVAEVAFKTQRWMHKSSFTQRSGLTDIARPKLPISRTFNMESTIFRSYFACTYRDGTIKIVHRQTYQVLYTASMDQLINFKSLNESSCDPPGEKRLRLSSSSGPAPPPHLLSAVQTTTGCGLVGLGEGRLYLFRVFNCSGTGGDTALQMLPLFVVLLLEYTMFCGLDVWDVLLAVRQGMVEGIVDKLSSNFAKQSGAFQELLHQRLLRHKMALYSCLGPGNQRASDCRASITLHAITTVLKGCLRPKAISAQDKSPSEKLSNLCMISPEMDLDQIAKAIDPEEFVLESFKESGGTKSQADVSLQSLQPTIQWIADFILHLLAAVSMYPHYLGFPGATLLKDPQILSTLRELLIIIRVWGRLSPACLPVFMTTVTTLDPLPYLFRLVTTAWAAARDGMNVENDQVFMDECCSLHSKVLIPNYKKSFGEEMNCYLAFSQPFPINYQFGVEPHFLLSGSSSHHHHHRPFPQDLCLDADQKYDCVRQIQLGVRPREPLRECVRCKALSLRRKPSATKSALLRAWELRFVKSCLCGGHWKHVIISNSH
Length752
PositionTail
OrganismElysia chlorotica (Eastern emerald elysia) (Sea slug)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Sacoglossa> Placobranchoidea> Plakobranchidae> Elysia.
Aromaticity0.09
Grand average of hydropathy-0.037
Instability index47.91
Isoelectric point8.41
Molecular weight83923.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23276
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     420.71|     138|     249|     224|     472|       1
---------------------------------------------------------------------------
   56-  220 (206.86/127.87)	GKKPVDGWI.AV.TSIGMVHVGllLEQGSSSMLTAKACLGqtnthiTQADVAFTADGQLLVVTSDGNVASSIHCYLVRIALknhicsvqstpsasfflkRQPMPEGITQE..PRLTRLSFLSRE........NSEVLLACWGTA...SFSCIEAWHLLDQTIPLNRMFQNVAeVAFKTQR
  312-  464 (213.84/373.89)	GPAPPPHLLsAVqTTTGCGLVG..LGEGRLYLFRVFNCSG......TGGDTALQMLPLFVVLLLEYTMFCGLDVWDVLLAV..................RQGMVEGIVDKlsSNFAKQSGAFQEllhqrllrHKMALYSCLGPGnqrASDCRASITLHAITTVLKGCLRPKA.ISAQDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.39|      14|      15|     688|     702|       3
---------------------------------------------------------------------------
  688-  702 (22.55/19.59)	DCVRQIQLGVRpREP
  705-  718 (26.85/17.12)	ECVRCKALSLR.RKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.02|      16|      19|     617|     635|       4
---------------------------------------------------------------------------
  617-  635 (24.69/25.50)	E.CCSL.HSKVLiP.NYKksFG
  637-  655 (22.33/11.67)	EmNCYLaFSQPF.PiNYQ..FG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23276 with Med16 domain of Kingdom Metazoa
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