<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23268

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLSTSDLEKLLKHSTEATYRLPVVVSPHGVRGSLTGCSSSDLVKQSYFSSSAKFRVSNGIIGLPYHVSQGVGCQLRGQNCFVEVSLGFARSGTDKALQTNRNIVRNLPKSPVMGQSDHKGSPDHLLVNEKTFLYPAEAVLVPVFQTSLARSSLRRFWLQNWMGPSLTGSSSFIHCAGNVESTEDPWTEINGSRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGLSELEADADSLTCRQSMVSSGRLGSDGSILGSKRSRTGVTQSLSMTTHIPGQDAYMSDFGSMEVNNSAITRVGNEPIGSIWDWDDEEDKGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALILSAPDCGDVNSSPAGASAMDVSDQMLLPIGFSSFESFDPTPPSVMEECLNKGQDNLSNSMQMGPTNQTQMMYTREYDHVMKAEAMMTFAQEFGAVEAPTSGLSTALFRSPYFPKSRKAESSNSCSNNYLYGAEPPSSPYIEGSEGKNGLVINTKTCSGKHDTSMTLHSKNYYTFVDSRKDINDKKPVTCIDNSIAKSEGIVQPPFSNIGSNASVKSVLRKMTGGTKEADHFVLSAKNLLATDVTCAMLQASMCRLRHTLLSSGNNLLSVGLSRSTGVTFSNQLPTDPSTTTDISGKYEVKKKENIPVRIAGDIDGGMLDGHLNAPVGVWRSVGASKVVKPSNSPNIDVGSSFSHNSFNEESLLSYGQRKPLQELLDGIALLVQQATSFVDLALDADCGDGPYGLLAMQEQWRRGFCCGPSMVHAGCGGTLASSHSLDIAGLELVDPLSSDVHASTVISLLQSDIKTALKSAFSNLEGPLSVTDWCKGRNQLVDTGSIVDGVSAESSISECRDSSEPMSPSQSSVCGSSSIKVSSIMDNAKVDETSQRRSGQDSESEQHPSSRLKPTLIAVPLPSILVGYQDDWLKASANCLQHWEKAPLEPYALQKPITYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHLPLGLGNQMEIEPAKSSTCGFVLLDCPQSMKIESSNASLVGSVSDYFLSLSNGWDLTSYLKSLSKALRALNLSSCFSANPTEGSNSSSLVIYVVCPFPDPTAILQTVIESSVAIGSVIQQSDRERRSSLHSQVVKALSGWATVDEASASNILVLSGCSIPKLVLQIVTVDAIFRVTSPSVSELVILKETAFTVYNKARRISRGISSDLAQLAFSSRSQSALAQMPSPISGMWKDCVGPRMVGHSLPRESDIDASLRPGNWDNSWQPARSGVLNCDPSRTGDIFLHDEIRYMFEPLFILAEPGSPEHGISVISSPSSEASKALADDSSGNHGQSTNTAGNVDSASSIDGSGSDQKTHPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQVLQQGCLILQSCDPGLAKPRDFMIARIGGFYELEYLEWQKAIYSVGGSEMKRWPLQLRKSLSDGASSTSNGSSLQQTDMSLIPERTLPSSPSPLYSPHAKQTGFIKGSLDGQPAARKQLMSGHSMVDSSRGLLHWAQSISFVAVSMDHTLQLVLPADSSSPGYVEGFTPVKSLGSASSAYILIPSPSMRSLPPTALQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGSNIPQEKIVRGVNKQGGRGLSWDAKDFETETHLILESLAAELHALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1756
PositionKinase
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index54.66
Isoelectric point5.44
Molecular weight189248.67
Publications
PubMed=26259924

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23268
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1009.75|     441|     826|     376|     855|       1
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  164-  321 (89.44/28.82)	.......................................................................................PSLTGSSSFIHCAGNVESTEDpwteiNGSR..TQNSYDSSS...NSNSSSIS.SLSA.....SSSD...SDYkttGLSELEAD.ADSLTC.......RQSMVSSGRLGSDGSILGSKRSRTGVTQSLSMTTHIPGQDAYM.SDFGSmeVNNSAITRVgNEPIgSIWDW....DDEEDKGMEMDIQ.................................................................................................................................................................................................................................................................................................................................................
  353-  613 (291.39/175.85)	...........................................................................................................................................LILSA....pDCGDvnsSPA...GASAM..........................................................................................................................................................dvSDQMLLPigfSSfeSFDPT....P.PSVM...EECLNKGQDNLSNSMQMGPTNQTQMMYTREYdHVMKAE......AMMTFAQEFGAVeAPTSGLSTALfrsPY.F.....................PKSRKAESSN.....SCSNNYLYGAEP.PSSPYIEgSEGKNGLVINTKTCSGKHDTSMTlHSKNYYTFVDSrkDINDKKPV..TCIDNSIAKSeGIVQPpfSNIGSNASVKSVLRKMTGGTKEADHfvLSAKNLLATDvTCAM....LQASMCRLRHTL
  614-  855 (252.12/145.51)	LSSGNNLLSVGLSRStGVtfsnqLPTDPSTTTDISGKYEVKKKENiPVRI...AGDIDGGMldGHLNAPvgvwrSVGASKVVKPSNSPNIDVGSSFSHNSFNEESLLS.....YGQRKPLQELLDGIALLVQQATSFVDLALDA.....DCGD...GPY...GLLAMQEQWRRGFCC.......GPSMVHAGCGGTLASSHSLDIAGLELVDPLSSDVHASTVISLLqSDIKT..ALKSAFSNL.EGPL.SVTDWckgrNQLVDTGSIVDGV.................................................................................................................................................................................................................................................................................................................................................
  907- 1172 (216.19/92.90)	................................................................................................................................................................................................................................................................................saessisecrdssepmspsqssvcgsssikvssimdnakvdetsqrrsgqdSESEQHP...SS..RLKPTliavPlPSILvgyQDDWLKASANCLQHWEKAPLEPYALQKPITY.HVVCPDidpltsAAADFFQQLGTV.YETCKLGTHL...PLgLgnqmeiepaksstcgfvlldcPQSMKIESSNaslvgSVSDYFLSLSNGwDLTSYLK.SLSKALRALNLSSCFSANPTEGS.NSSSLVIYVVC..PFPDPTAIlqTVIESSVAIG.SVIQQ..SDRERRSSLHSQVVKALSGWATVDE..ASASNILVLS.GCSIpklvLQIVTVDAIFRV
 1252- 1431 (160.62/64.92)	LRPGNWDNSWQPARS.GV.....LNCDPSRTGDIFLHDEIRYMFE.PLFIlaePGSPEHGI..SVISSP.....SSEASKALADDSSGNHGQSTNTAGNVDSASSIDG.....SGSDQKTHPSLHCCYGWTEDWRWLVCIWTDSrgellDCNI...FPF...GGIS.SRQDTKGLQClfvqvlqQGCLILQSCDPGLAKPRDFMIA...................................................................................................................................................................................................................................................................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.54|      51|     274|    1194|    1251|       2
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 1194- 1251 (83.34/51.47)	ARRISRGisSDLAQLAFSSRSQSALAQMPSPI.......SGMWKDCV.G.PR.....MVGHSLpresdIDAS
 1471- 1535 (71.20/31.80)	ASSTSNG..SSLQQTDMSLIPERTLPSSPSPLysphakqTGFIKGSLdGqPAarkqlMSGHSM.....VDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.64|      18|      33|       3|      20|       3
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    3-   20 (30.70/21.30)	STSDLEKLLKHSTEATYR
   38-   55 (30.94/21.54)	SSSDLVKQSYFSSSAKFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.38|      29|     193|    1435|    1469|       5
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 1435- 1469 (50.01/45.94)	GFYeleyleWQKAIYSVGG...SEMK.RWPLQLRKSLSD
 1631- 1663 (42.38/26.03)	GFV......VSKAVPSMRKdyrSNLKeEWPSVLSVSLID
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23268 with Med13 domain of Kingdom Viridiplantae
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