<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23237

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWERWPKSTHCPSVPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWDVHSVNSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESHVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNVFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQSMAVFYSSAAPRSADEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPGMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCKLSPCTVARVCDYHAKLFLVAVSSTLKSLLRPHFLNTPDKSPGDRLTEVCTKITDADIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPTLPTSASTLQLDGLIRAPGQPKIDHLRRLHLGAYPTEECKTCTRCGCVTMLRSPNKTTAVKQWEQRWIKNCVCGGLWRRVPLSYP
Length829
PositionTail
OrganismVulpes vulpes (Red fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Vulpes.
Aromaticity0.07
Grand average of hydropathy0.016
Instability index48.18
Isoelectric point7.71
Molecular weight91863.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.39|      30|      33|     713|     745|       2
---------------------------------------------------------------------------
  713-  745 (46.23/36.81)	LIPSLDWLPVsDGLVsRlQPKQP.....LRLHFGKAPT
  746-  780 (51.16/27.87)	LPTSASTLQL.DGLI.R.APGQPkidhlRRLHLGAYPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.24|      45|     200|      78|     124|       4
---------------------------------------------------------------------------
   78-  124 (75.04/57.95)	DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESHVGSLVeGD..PIVaLSW
  277-  327 (63.19/40.04)	DMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNVFQQISPVV.GDkqPMI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.23|      33|      35|     626|     658|      10
---------------------------------------------------------------------------
  592-  622 (25.73/11.31)	.......FVLDMNTL..QALQQLLqwvgdFVLYLLASLPN
  626-  658 (57.85/34.01)	PLRPGHSFLRDGTSL..GMLRELM.....VVIRIWGLLKP
  662-  693 (47.65/26.80)	PVYTATSDTQDSMSLlfRLLTKLW.....ICCRDEG...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.50|      15|      23|     782|     796|      11
---------------------------------------------------------------------------
  782-  796 (30.13/13.78)	ECKTCTRCGCVTMLR
  808-  822 (31.37/14.57)	EQRWIKNCVCGGLWR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23237 with Med16 domain of Kingdom Metazoa
Unable to open file!