<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23146
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQNVQHQLLQSPARLGLPTPSSPSLQNTTPPTKFSSQASQPNQQANILTTTTTSSTLLPLLPPLSRAQSLLIQMASLASRLFEVSPNRSHWLSAFRGSFPSFLPSTAPVPQDSSPSSSKEILSAFTSLQTQLFEAVAELQEILDLQDEKQKVTREIRLNDSAILAFANKLKGAEHVLDNLVDDYADYRRPKRAKLENDTEESSLTSVATQLKLSDVLSYAHRISYTTFAPPEFGGGQAPLRGALPPAPQDEQLRASQLYIFADLDVGLPKTDEGKENILEPLIEPPAESNPLAYLSSIQGLVPPNIVVPSGWKPGMPVELPTDLPLPPPGWKPGDPIALPPVDSRPPQKNPWFEKPESVWQRSYYNILNVALWDFDK |
Length | 378 |
Position | Middle |
Organism | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
asterids> lamiids> Solanales> Solanaceae> Solanoideae> Solaneae> Solanum>
Solanum subgen. Lycopersicon.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.378 |
Instability index | 77.21 |
Isoelectric point | 5.10 |
Molecular weight | 41563.53 |
Publications | PubMed=22660326
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP23146
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.62| 16| 16| 307| 322| 1
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307- 322 (34.34/17.11) I.VVPSGWKPGMPVELP
325- 341 (31.28/14.97) LpLPPPGWKPGDPIALP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.88| 34| 39| 211| 248| 2
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211- 248 (55.03/38.50) QLKLSDVLSYAHrisyTTFAPPEFGGGQAPLRGAL..PPA
253- 288 (53.85/28.86) QLRASQLYIFAD....LDVGLPKTDEGKENILEPLiePPA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.91| 13| 30| 20| 32| 3
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20- 32 (24.93/ 9.82) TPSSPSLQNTTPP
52- 64 (22.98/ 8.55) TTTSSTLLPLLPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.62| 11| 27| 86| 96| 5
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86- 96 (23.71/13.59) SPNRS.HWLSAF
115- 126 (15.92/ 6.87) SPSSSkEILSAF
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|