<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23145

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRAAEESYVTLKELVEKCKSSNLSDSEKKIGILKYVVKTQQRMLRLNVLSKWCQQVPLIQYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYDRLPKCIEDVGLQSTLNDDQQKPALKKLDTLVRSKLLEVSLPKDITEVKVSDGTVLLRVEGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADHPFMTLYSILHELCVALVMDTVIRQVQTLRQGRWKDAIRFELITDVSTGQAGSAGSTQTSQDGESDSASLRTPGLKILYWLDLDKNSGTSEIGTCPFIKIEPGPDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDIEKLLLRVICCNRYTRLLEILKELEKNSQICRVPSDIQLQCHVEEMLGDSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGRFILHSSKNVISSSVVVECEEALNQGSMSAAEAFISLRSKSILHLFACIGRFLGLEVFEHGSAAVKVPKSISSGTNLLLMGFPECGSSYFLLMELDKDFKPVFKLLESRSDSPAKAQSLADLSNVVRVETIDVGRMQICEDELNLSLLNSKKLLSVLRSDGGSHQTSENSLLADFSLEGSIVASGVQSTFLSIVDEVFELEKGSSVPSFSGQIPPSTFGASPASHFGTGVANYQSLKVGTLSPKWDRGVGNYSNSMYKGVIQSGSVGSLAATQTGKKLTASKSEQDLTSLRSPHSAGVGSYTSLDEDQLTVSTNRSARLLSPPHRVSASSGKASGSRNSAVGTLPGGFRTADSNSLVLSPGSQTIDSATCIKSEQDAASGYNILPRKRTLSDLLDSLPSLQSMQSNEGSYKRRKLVESAGTHLPKSMMLTSSDISGKTEEYSYGSLIAEANKGNAPSSIYVSSLLHVVRHCSLCIKHARLTSQMEALDIPYVEEVGLRSASSNLWFRVPFARDDTWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWDSGIRIANTSDADSHIRYDCEGVVLSYYSVDADSIKKLVADIQRLSNARTFALGMRKLLGARADEKFEENNANSESKAPAALKGTTDATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTAPISSVAKQTGYVPSLPSNVNSSINQPAPGAGVNPVSASVGTLGAHSHPSAAMLAAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKKFAVDMRCFAGDQVWLQPATPPKGGPEVGGSLPCPQFRPFIMEHVAQELNGIDSNFTGSQQAVGVPNSNSLNAGSQLPAANTNRTNLSNSTGLARPANAVTGFNRTANGLPAASNLAGVNAGMPLRRAPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQQQQNPGSAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHAGYSIDGSSENTSASKSNIHYDRAHNSVDFALTVVLDHAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVLFLGMEGSHGGRACWLRVDDWERCKQRVARTVEVNGNSAGDANQGRLRVVADSVQRTLHAYLQGLRDGGGVAAGIGS
Length1791
PositionTail
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Solaneae> Solanum> Solanum subgen. Lycopersicon.
Aromaticity0.07
Grand average of hydropathy-0.159
Instability index43.81
Isoelectric point7.23
Molecular weight194298.50
Publications
PubMed=22660326

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23145
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.25|      36|      37|    1209|    1244|       1
---------------------------------------------------------------------------
  669-  692 (26.62/ 9.35)	.........SSVPSFSGQIP..PSTFGAS...PAShfG
 1209- 1244 (61.03/30.99)	GVPGVTAPISSVAKQTGYVPSLPSNVNSSINQPAP..G
 1246- 1281 (57.60/28.83)	GVNPVSASVGTLGAHSHPSAAMLAAAAAAAGRGGP..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.72|      14|      19|    1413|    1426|       2
---------------------------------------------------------------------------
 1396- 1410 (16.99/ 7.91)	SNSTGLARPANaVTG
 1413- 1426 (24.72/15.65)	RTANGLPAASN.LAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.49|      32|     326|    1428|    1465|       3
---------------------------------------------------------------------------
 1428- 1465 (49.30/35.38)	NAGMpLRRapgtgVPAHVRGELNTAIIGLGDDGGYGGG
 1757- 1788 (53.18/24.16)	NQGR.LRV.....VADSVQRTLHAYLQGLRDGGGVAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.44|      75|     162|     944|    1032|       5
---------------------------------------------------------------------------
  944- 1032 (122.47/101.54)	RLTSQMEALdiPYVEEVGLRSassnLWFRVP...FAR.DDTWQHiclrlGRPG.SMYWDvkiNDQ...HFQDLWELQKGSNSTPWDSGIRI.........ANTSDA
 1111- 1202 (107.97/62.21)	RISEQMRKQ..FRIEAVGLMS....LWFSFGsgvLARfVVEWES.....GKEGcTMHVS...PDQlwpHTKFLEDFINGAEVASLLDCIRLtagplhalaAATRPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.53|      14|     326|     265|     305|       6
---------------------------------------------------------------------------
  265-  278 (22.35/16.75)	VIRQVQTLRQGRWK
  306-  319 (23.18/16.60)	GESDSASLRTPGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.19|      51|     164|     582|     657|       7
---------------------------------------------------------------------------
  605-  657 (78.76/71.38)	EDELNLSLLNSKKLLS...VLRSDGGSHQTSENSllADFSLEGSIVASGVQSTFLS
  771-  824 (78.43/32.72)	EDQLTVSTNRSARLLSpphRVSASSGKASGSRNS..AVGTLPGGFRTADSNSLVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.99|      49|     161|     340|     414|       8
---------------------------------------------------------------------------
  340-  356 (15.70/24.94)	......................................................FIKIEPGPDLR..IKCLHS
  380-  414 (35.26/17.54)	EKLLLRVICCnrYTRLLEiLKELEKNSQICRVPSD......................................
  504-  573 (67.04/25.30)	SKSILHLFAC..IGRFLG.LEVFEHGSAAVKVPKSissgtnlllmgfpecgssyFLLMELDKDFKpvFKLLES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.96|      31|      37|     825|     855|      10
---------------------------------------------------------------------------
  825-  855 (52.61/29.65)	PGSQTIDS.ATCIKSEQDAASGYNILPRKRTL
  863-  894 (48.35/26.69)	PSLQSMQSnEGSYKRRKLVESAGTHLPKSMML
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23145 with Med14 domain of Kingdom Viridiplantae
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