<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23135

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMQIWRRRSGPPPGLSSAVPEGAAARREQPAGSWHGCACAVELSRLRSTPPPVPGSSDGFGVRVRVGEAAEERPLPAHPAGVRLVLPQPHRLHHRPAERGGARCGPPPFPPPPLTHSPRCSRGPSAFPLPPPRPANGAGVRLSLRADLTHMVHIIDTEHPWDVYSVNSGHVEAITCLEWDQSGSRLLSADADGHIKCWSMTDHLANSWENTMGSMVEGDPVVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADVAFTGGGNIVVATSDGSSASPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNNSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQMMAVFHGSSSQRPVDEQTIKRQRTTGPLVHFKAMQLSWTSLALAGIDSHGKLSMLRISPSMGHVLDMNTSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYTRQSAALQQVLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEVCSKITDIDIDKVMINLKTEEFVLEMNTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMFRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCREESHITEPDDTLIDECCLLPSQLLIPNIDWLPINDGIISKLQNKQLVRLQFGKAPGLIGHTVSSQFDAFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKVTAVKQWEQRWVKNCLCGGLWRRMPLSYS
Length930
PositionTail
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.06
Grand average of hydropathy-0.074
Instability index50.92
Isoelectric point8.87
Molecular weight102766.09
Publications
PubMed=15592404

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP23135
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.18|      19|      95|     517|     554|       1
---------------------------------------------------------------------------
  536-  554 (34.54/52.71)	DSHGKLSMLRISPSMGHVL
  635-  653 (32.64/10.22)	DYHAKLFLIAISCTLKSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.79|      37|      95|       7|      46|       2
---------------------------------------------------------------------------
    7-   46 (61.09/44.81)	RSGPPP......GLSSAVPEGAAARREQPAGSWHGCAcaVELSrLR
  102-  144 (63.70/35.68)	RCGPPPfpppplTHSPRCSRGPSAFPLPPPRPANGAG..VRLS.LR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     407.08|      92|      95|     336|     428|       3
---------------------------------------------------------------------------
  172-  225 (62.39/39.41)	.......................................AIT.....CLEW...DQSGSRLLSADADGH..IKCW.SMTDH...L.A..NSWEN..TmgSMVEGD..PVVaLSW
  242-  321 (74.88/48.78)	SNFGEKfSRVKFS..PSLtlF...G.GK..PM..EG.WIAVTisglvTVSLLKPN..GQVL..TSTESLCRLRCRvALADVAFTGgG..NIVVA..T..SD.............
  336-  428 (156.56/117.13)	SVVNEK.CKIDTEILPSL..FMRCT.TD..PARKDK.YPAIT.....HLKFLARDMSEQVLLCASNQNNSIVECW.SLRKEGLPV.N..NIFQQ..I..SPVVGDKqPMI.LKW
  432-  527 (113.24/78.78)	SATNDL.DRVSAVALPKL..PISLTnTDlkVANDTKfFPGL......GLALAFHDGSVHIVHRLSLQMMAVFHGS.SSQR...PV.DeqTIKRQrtT..GPLVHFK.AMQ.LSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.22|      14|      17|     835|     850|       4
---------------------------------------------------------------------------
  835-  850 (21.77/19.03)	QLVrlQFGKAPGL..IGH
  855-  870 (22.45/12.45)	QFD..AFVRAPGQpkIDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.75|      45|     135|     555|     607|       5
---------------------------------------------------------------------------
  555-  607 (60.36/56.31)	DMNTsLRHLLFLLEYcmvTGyDWWDILLHVQPNmvQ.NLVEKLHeEYTRQSAAL
  696-  741 (77.39/42.07)	EMNT.LQSLQQLIQW...VG.DFVLYLLASLPN..QgSPVRPGH.SFLRDGASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.83|      17|      17|      60|      76|       6
---------------------------------------------------------------------------
   60-   76 (28.51/12.94)	GVRVRVGEAAEERPLPA
   80-   96 (31.32/14.85)	GVRLVLPQPHRLHHRPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.71|      23|     135|     665|     687|       7
---------------------------------------------------------------------------
  665-  687 (41.34/29.06)	PGDRLTEVC....SKITDIDIDKVMIN
  798-  824 (38.38/26.41)	PDDTLIDECcllpSQLLIPNIDWLPIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23135 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MQIWRRRSGPPPGLSSAVPEGAAARREQPA
2) RLRSTPPPVPGSSDGFGVRVRVGEAAEERPLPAHPAGVRLVLPQPHRLHHRPAERGGARCGPPPFPPPPLTHSPRCSRGPSAFPLPPPRPANGAGVRL
1
44
30
141










Molecular Recognition Features






MoRF SequenceStartStop




1) MQIWRRRS
1
8