<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23130

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGSGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDASKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGVNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITSETLQLSNYSTHPIGNLSKNKLFVRLTRLPQYYIVVEMLEVPNKPTQLSYKYYFLSVNAVDRDDSPLMALLLQQFKENLQESVYRTKNGKQPRTSTKRKLSDDLCPVEPKKTKRSGEMRAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGINEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPSHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1408
PositionTail
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index50.82
Isoelectric point8.99
Molecular weight156543.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.79|      32|      32|    1055|    1086|       1
---------------------------------------------------------------------------
 1011- 1050 (33.89/11.54)	.P.GSSGAYPlTSPPTSyhstvNQSPSmmhTQSP.GtLDPSS..P
 1055- 1086 (66.70/29.57)	SPSGRAGNWP.GSPQVS.....GPSPA...TRMP.G.MSPAN..P
 1090- 1119 (44.19/17.20)	SPVPDASH....SPR.A.....GTSSQ...T.MPtN.MPPPRklP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.80|      30|      31|     244|     273|       2
---------------------------------------------------------------------------
  244-  273 (48.45/28.89)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  274-  307 (45.35/26.58)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      25|      32|     509|     537|       3
---------------------------------------------------------------------------
  509-  537 (38.09/33.10)	HLPT..ITSETLQLSNYSTHpignLSKNKLF
  542-  568 (41.04/24.43)	RLPQyyIVVEMLEVPNKPTQ....LSYKYYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.09|      24|      24|    1317|    1340|       5
---------------------------------------------------------------------------
 1315- 1338 (41.24/22.91)	SKMLFFL..QLTQKTSVPPQEPVSII
 1339- 1364 (35.86/18.91)	VPIIYDMasGTTQQADIPRQQNSSVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.27|      32|      32|      64|      95|       6
---------------------------------------------------------------------------
   64-   95 (51.36/34.91)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
   97-  128 (52.92/36.20)	LLALVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1201|    1215|       7
---------------------------------------------------------------------------
 1201- 1215 (21.47/16.58)	LKCRVALSP.KTNqTL
 1239- 1253 (22.14/11.68)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.37|      28|     158|    1120|    1151|       9
---------------------------------------------------------------------------
 1120- 1149 (44.22/36.12)	QRSWAAS..............IPTILTHSALNilLLPSPTPGLV
 1153- 1194 (38.15/17.81)	AGSYLCSplerflgsvimrrhLQRIIQQETLQ..LINSNEPGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.96|      36|     402|     570|     605|      10
---------------------------------------------------------------------------
  570-  605 (59.74/35.84)	SVNAVDRDDSPLMALLLQQFKENLQESVYRTKNGKQ
  975- 1010 (67.22/41.35)	SVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.60|      89|     508|     363|     455|      11
---------------------------------------------------------------------------
  363-  455 (141.83/111.40)	DASKPLQIFHD.PPLPASDskLVERA.MKIDHLSIekLLIDSVHAR.AHQKLQ..ELKAILRGVNANENSSIETALPALVVPILEPC.GNSECLHIFVD
  872-  966 (134.76/93.82)	DTQAPLNAINKlPTVPMLG..LTQRTnTAYQCFSI..LPQSSTHIRlAFRNMYciDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPApGLKTFLNMFVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     247.45|      59|     441|     165|     239|      13
---------------------------------------------------------------------------
  165-  223 (99.35/42.99)	PRLPT..CIRDKIIPPDPITKIEKQATLHQLNQILRH..RLVTTDLP.....PQLANLTVANGRVKFR
  606-  672 (77.84/31.03)	PRTSTkrKLSDDLCPVEP.KKTKRSGEMRAFNKVLAHfvAMCDTNMPfvglrLELSNLEIPHQGVQME
  677-  726 (70.26/32.50)	SH.....AIRLLKIPPCKGINEETQKALDRSLLDCTF..RLQGRNNR.....TWVAELVFAN......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23130 with Med14 domain of Kingdom Metazoa
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