<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23125

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSERSEMEHAVARVGAGTIPLSILIEFISQKVYTDLMRLIDLLPSKTDLEKKIEIATFFSRTQHLFIRLEALVKWSNSASKVDKCEKISNFLEEQSFFLISTANALSRLLRETLVSARLPPFSVLLAIDIFTNKGYTRLPKSIKNCAFVAESVTEKEKKQALIDLNCIIQNRLSLTQLPHQFRTIKIADGRAEFVVQNEFAVTVTLMSEALDFPWRILDLKFLLKDSSMNYQNLVHPAQTRLIINQAQSRLLYRQFDNRPPLVHLYDMLHAFSLSLQLDMLHEQAQRARSKRPPDQLTIEAYRPSRCLSISYWHGLARTQYNSVMGLDGKLHPTAYLLTIHIDPTEPQRPLCVSHRPELTTSKSQLVGATVQGDCLSIETLLTRTMVARAEQMLQDLRQELLIISPGPVRLADAPLCLYVPLLWPCSPHELLQVRIDPVQGFVCTSFPLLTSLDTEFGAIGSVVVSADFSSSTGVSENFSRSSVINTLSSLESAFNQASCHRVRLVSATGALVQPHESDRICSIQSRSLRNLSHGDARWRSVIRECLEHLRLCLGLARLMQTAKIHRPFWQPFKRHLPLILSPAQVNLSSSWSKMLVRLQQSYRWPILFAQLFPNNEYYIACEVISGPLSVDYKYYLIVCSALPEHMNITTNLQGVLVFNSEINPASGHLNETGLFLQVTHFTSLIADTVWSNNPSTTLEQLCACIKKAQSTIVNQRSTRLNELLNKLKLSHTIDSESVYNDTVVTRKSMRLFEPQATVPTLARLIGTLEENILTNYLTVELSCAGIEHNGMRYDGAGCLSAITITSIPFDPPSWHPSDIIPLVDFVHEMILRPHFDPFTHRRSWQLDIVFTGIVAPLNGINQKSSTYLRHQTAEWTVARLEHFNIVVQNILVEWEKLCLMHALCYHVITNPDVYLPKGAQVYSYNLRTLSLIYGTYYLADISNPTGHKFTLALGFRPTSLNNSSDTTRELNSDDINMSNTINVDFNPHMIARQHLEELLNTRKSIYSLATTMLNTLEFFRCVEPLRDQVLSYNGLKVISPHNHCLQAVCGMLLIALSPNDLILIYRASLSLRITLNIIEHSIVSSTMLSSNNNNDTLKRTKSIQLHDAYNQLTTGKKPYPPIFNTDGWNNQMLDDKALCNLAPLPAFSKFLKSVQELFCINSDEKLTSLTFTQFAQLTILTFDKFKSGIISSKTFSPTNCRRTDPGPTLLESYLSTSLLFHAAILAIQSLDVPIHHVHNEIPYDQQQQTDEQQRIKNQHDLLENAVFICVWPVSQLTVQLSMLCQPTTSNGIESFWWRLKLQLSQSVNSCDRWPPETLNVFEEFFDKRVCSFPFQPSAVTAFFRLLLLPPHALRAMGRVLAFDLHSPAQAPVYVRIGLIGMGVNSRVTAISSSSSLTNQPPNAAASATTGAAQNLLTFDTGSDLQPGMPGIIVRPSKITLQLLITRSHSRHLSKNLIPLAQLVVVGYDWDVNHVVIYPTINQSQNITTNNRNQSDTINLNLLRLLHDTDVESKANAMATNSNDSALVQLVLLITQTVAASYPISSSDSTSLNNSNVMTGFGIGGGGGGNVNSGAGIGSQQVLYG
Length1585
PositionTail
OrganismSchistosoma mansoni (Blood fluke)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.08
Grand average of hydropathy-0.047
Instability index43.89
Isoelectric point7.73
Molecular weight177671.98
Publications
PubMed=22253936

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23125
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     950.07|     309|     579|     506|     936|       1
---------------------------------------------------------------------------
  234-  491 (310.00/157.16)	LVHPAQTRLIINqAQSRLLyRQF...DNRPPLVhLYDMLHAFSLSLQLDMLHEQAQRARSKRPP..DQLTIeAYRPSRC.LSISYWHGLARTQ..YNSVMgLDGKLHP.TAYLLTIHIdptePQRPLCVSHrpelttsKSQLVGATVQGDCLSIETLLTRTMVARAEqmlqdlrqelliISPGPVRLADAPLCL....YVPL....LWPCSPH....ELLQVRIDPVQG.FV...CTSF.PLLTSLDTEFgAIGS......VV..VSADFSSSTGVSENFSRSSVINTLSSL.........................................................................................
  512-  847 (495.92/472.85)	LVQPHESDRICS.IQSRSL.RNLshgDARWRSV.IRECLEHLRLCLGLARLMQTAKIHRPFWQPFKRHLPL.ILSPAQVNLSSSWSKMLVRLQqsYRWPI.LFAQLFPnNEYYIACEV....ISGPLSVDY.......KYYLIVCSALPEHMNITTNLQGVLVFNSE............INPASGHLNETGLFLqvthFTSLiadtVWSNNPSTT.LEQLCACIKKAQSTIVNQRSTRLnELLNKLKLSH.TIDS......ES..VYNDTVVTRKSMRLFEPQATVPTLARLIgTLEENILTNY...LTVELSCAGIEHNGMRYD..GAGCLSAITITSipfdppswhpSDIIPlVDFVHEMILRPHFDPF..THRRSWQL
  940- 1009 (69.09/22.79)	......................................................ADISNPTGHKFT..LAL.GFRPTSLNNSSDTTREL.............................................................................................................................................................................................................................................................nsddinmSNTIN.VDFNPHMIARQHLEELlnTRKSIYSL
 1271- 1392 (75.05/ 8.39)	..............................................................................................................................................................................................................VWPVSQLTVqLSMLC...QPTTSNGIESFWWRL.....KLQLSQ.SVNScdrwppETlnVFEEFFDKRVCSFPFQPSA.VTAFFRLL.LLPPHALRAMgrvLAFDLHSPAQAPVYVRIGliGMGVNSRVTAIS..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.46|      38|     154|    1037|    1102|       2
---------------------------------------------------------------------------
 1056- 1096 (57.10/78.20)	ALSPNDLILIyraSLSLRITLNIIEHSIVSSTMLSSNNNND
 1519- 1556 (61.37/24.12)	ATNSNDSALV...QLVLLITQTVAASYPISSSDSTSLNNSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      30|      32|      30|      59|       3
---------------------------------------------------------------------------
   30-   59 (48.24/38.12)	QKVYTDLMRLIDLLPSKTDLEKKIEIATFF
   63-   92 (49.82/39.66)	QHLFIRLEALVKWSNSASKVDKCEKISNFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.04|      57|     572|     870|     936|       5
---------------------------------------------------------------------------
  870-  936 (85.60/86.49)	RHQTAEW.TVARLehfnIVVQnilVEWEklcLMHALCYHVIT.NPDVYLPKGAQVYSYNLRTLSLIYGT
 1451- 1509 (89.44/61.50)	RHLSKNLiPLAQL....VVVG...YDWD...VNHVVIYPTINqSQNITTNNRNQSDTINLNLLRLLHDT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23125 with Med14 domain of Kingdom Metazoa
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