<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23119

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAFLDKQSMLFVDTADMLARVARETVVHARLPNFHIPAAVEVLTTGSYSRLPACIRERIVPPDPITPAERRSTLQRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFYVEHEFEVALTVMGDGPNIPWRLLDIEILVEDKETGDGKALVHPLQVEYIHRVVQARIADHPNPLTEVYNCLHFFCQELQLEVLYSQTMRLGRDRLDGHIHVDEYSPGKCLTISYWRELTSKDPRSELGYRLTVHVDRHDPARPLTVLHVPALGNKECEIADRAIRSELLSMERLLVHTIYVRTKNRLTDLKQELQTLLKHVEREFYYPDFTTLQGSPAILSVPVLQPCLRAEMLLITVDTHTGMLQCHVPQYDTPLMTELQAAFNGDHSRLLALLSELRFWMAQRRCEKTLQHLPATPYERLPLLHHSEHPISRIGRHKMFIRLHRHPNIILIVEFKEKENAADMECHYYLIFVKHSSIEDDPNDETIETDIPKVYLKVLTLIEFDTFVITHGPFTAVDETLDKTNGKRKLPLSKYDSAKRSKHPAYFISDLAHVVALCDERVPFAILAQELTKRDIAHQGLQIEANATSLVLKIIQLPQPTGMTSQTGWNSLLKRLLSVSIRVHSKTTGTMGCWMVEFVIYGSPLGSTHPKEQGMRRAVYFQYELGTADSIAKTVEAFLNDWAQIVHLYVLMEDLAEYMKSEKSNQIANLFSIKSYSYSKFILSYGPGGHATVNIFWNTHAHGFSLIFGSIHQSINAHVLMREQLEAHLNTHRNLAQLIHILNSTYKPLFSISKLSTIPQLGVHSNRPQVPVCTFTIIPQSATLVRIVYLGMYCLEITFRGGGLVSIRDGAYSRFDRTSVISDFMPTSGLRAFLENNVDDSAVFRRRSQSEDDNPPSPVTMECGGGGGHHRGGPQSPAQQRDSLRFHPPLTPPSGSNPHTPSSPHPSNINQSSTQPPFGSSPATSFNLASPPNINPSPSMLPHSSPGPNLLVNSPSNPLHVPSPAGLSPAPSSMPIGHSPASNFMGGAHMDGSPFPSSQSMTSPAASNWPGSPGMPRPSPARPGMGHMSRVIPQRSWAGAVPTLVTYDSFDLLCSNSPHPLGLPCPDISPLERFLGCVYMRRQLHRFLQSEDFVTHLNTHQPGVVNFKVEHFQCRVWLNPQTLQSLHIKITLQPDHKDPWSSEELQILEKFFETRAAAPPYKPNAMLAFTRMLNCSQPVLKDFLSIMKLELSPGHPQAKWSVQWCLRIPPSATPIVPTGQAAVIICRSKLLFFVSITHRLPIQKLIPANLVYVSLEGSASAM
Length1290
PositionTail
OrganismDiaphorina citri (Asian citrus psyllid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Psylloidea> Liviidae> Diaphorina.
Aromaticity0.08
Grand average of hydropathy-0.217
Instability index57.85
Isoelectric point8.13
Molecular weight144741.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     224.41|      35|      37|     990|    1026|       1
---------------------------------------------------------------------------
  917-  949 (45.74/16.51)	..P..LT.PPSGSNP..H.TPSSPHPSNI.....NQSSTqpPFGSS
  957-  989 (30.36/ 8.61)	ASPPNIN.PSPSMLP..HsSPGPNLLVNSpsnplHV..........
  990- 1026 (65.67/31.18)	PSPAGLS.PAPSSMPigH.SPASNFMGGA.....HMDGS..PFPSS
 1038- 1064 (45.78/16.53)	PGSPGMPrP..........SPARPGMG.......HMSRV..IPQRS
 1086- 1108 (36.87/11.95)	PHPLGL..PCPDI......SPLERFLGCV.....YM..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.25|      27|      29|     734|     762|       3
---------------------------------------------------------------------------
  734-  762 (41.12/36.37)	LIfgSIHQSINAHVLMREQLE..AHLNTHRN
  766-  794 (41.13/28.04)	LI..HILNSTYKPLFSISKLStiPQLGVHSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.78|      17|      33|     201|     219|       4
---------------------------------------------------------------------------
  201-  219 (27.17/19.72)	RLDghIHVDEYSPGKCLTI
  237-  253 (30.61/15.28)	RLT..VHVDRHDPARPLTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.07|      27|      47|     355|     381|       5
---------------------------------------------------------------------------
  355-  381 (48.56/28.06)	HVP..QYD.TPLM..TELQAAFNGDHSRLLAL
  400-  431 (36.51/19.21)	HLPatPYErLPLLhhSEHPISRIGRHKMFIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.00|      36|      39|     524|     562|       7
---------------------------------------------------------------------------
  521-  559 (55.31/42.95)	SKYDSAKRS.KHPAYFISDLAHVVALCDervPFAILAQ....EL
  560-  600 (49.69/30.80)	TKRDIAHQGlQIEANATSLVLKIIQLPQ...PTGMTSQtgwnSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.81|      14|      27|     843|     856|       8
---------------------------------------------------------------------------
  843-  856 (25.98/18.00)	FDRTSVISDFMPTS
  872-  885 (26.84/18.89)	FRRRSQSEDDNPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23119 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SAVFRRRSQSEDDNPPSPVTMECGGGGGHHRGGPQSPAQQRDSLRFHPPLTPPSGSNPHTPSSPHPSNINQSSTQPPFGSSPATSFNLASPPNINPSPSMLPHSSPGPNLLVNSPSNPLHVPSPAGLSPAPSSMPIGHSPASNFMGGAHMDGSPFPSSQSMTSPAASNWPGSPGMPRPSPARPGMGHMSRVI
869
1060










Molecular Recognition Features






MoRF SequenceStartStop




NANANA