<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23087

Description Mediator of RNA polymerase II transcription subunit 14
SequenceAVTAPASPGYRLSGLIEFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGIASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKNYNANDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFHLMLYGIDQLTLDDVEKSVNDDMKRIIPWLQQLKFWLGQQHCKQSIKHLPTVSSDTLQLANYASHPVGSLSKHKLFIKLTRLPQYYIVVEMFEVPGNPTELEYKYHFLSVSCAEGDDSPATALLLQQFKPNIEELVLDTKSGKQAKSGAKRKLSGDPCSVEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRIELSNMDIPHQGLQVEGDGFSHAIRLLKIPPCKGVSEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLSSTTSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSFPDIPNHLNVFSEVRVYNYRKLILCYGTTKGSSISIQWNSVLQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMIHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAVQWKPEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMLNLTLPPGGRP
Length1417
PositionTail
OrganismAlligator sinensis (Chinese alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index53.17
Isoelectric point8.82
Molecular weight157251.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     214.25|      30|      32|     997|    1026|       1
---------------------------------------------------------------------------
  946-  989 (24.49/ 6.85)	.P.SPiggdmmdsliSQLQPQQPPQqqqpFAKQAGASGAypLTS...........P.P
  997- 1026 (58.04/27.16)	TP.SP..........SMIHTQSPGN....LHAASSPSGA..LRA...........PSP
 1032- 1060 (47.63/20.86)	TP.SP..........SSLGI.TMGQ....TANFASPHGT..IDP...........SSP
 1064- 1084 (31.05/10.82)	................MSPSQRAGN....WPGSPQVSG.................PSP
 1092- 1125 (27.24/ 8.52)	SPaNP..........SL.HSPVPDA....SH...SP......RAgtssqtmptnmPPP
 1134- 1158 (25.79/ 7.64)	AA.SI..........PTILTHSALN....ILLLPSPTPG..L................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     576.50|     189|     508|     139|     346|       2
---------------------------------------------------------------------------
   16-  189 (193.60/131.62)	...............................IEFlLHRtYAELTV.LADLLPRKtDMERKIEIVQFASRTRQLFVRLLAL.........V..KWANNAgKVE.....KCAMISSFlDQQaILFVDTAdrLASLARdalVHARLPSFAIPYAIDVlttGSYPRLPTC....irdkiIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN...GRVKFRVEG
  203-  342 (212.19/134.19)	DIPWRLLKLEILVEDKETGDGRALVHSM..QINF.IHQ.LVQSRL.FADEKPLQ.DMYNCLHSFCLALQLEVLHSQTLML.........IRERWGDLV.QVERYHagKCLSLSVW.NQQ.VLGRKTG..IASVHK...VTIKIDETDVSKPLQI...SHEPPLPAC...............................................................
  626-  701 (99.93/49.99)	DIPHQGLQVE........GDG.................................................................................................................................................fshairllkIPPCKGVSEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplSSTTSREQG
  702-  793 (70.78/32.36)	..PTRHVYLTYENQLSEPVGGRKVVEMFlnDWNS.IAR.LYECVLeFARSFP...DIPNHLNVFS...EVRVYNYRKLILcygttkgssISIQWNSVL.Q..KFH............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.28|      18|     416|     865|     887|       5
---------------------------------------------------------------------------
  865-  887 (26.26/24.61)	FSILPQSPTHIrlaFRNmyCIDI
 1266- 1283 (35.02/17.19)	FTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23087 with Med14 domain of Kingdom Metazoa
Unable to open file!