<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23058
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MIQHQIVQSPARLGLANPNSPSIPNPTPPKLPPTQTQQPQDRNSSTPSSALLSLLPPLPRAQALLLQMASLTSKIFEVSPNRSLWVTAFRGSLPTFLSSNSSTPLDASPSTVKEIISLFTVLQTQIFEAVAELQEILDLQDAKQKMDREIRSQDSMLLAFSNKLKDAECCLDMLVDDYSDYRRSKRSKSGDDDSMTSSTVSSQLKLSDILSYAHKISYTTFAPPEFGAGQAPLRGALPPAPQEEQMRASQLYNFADLDVGLPKEVESKEKIVEAIVEPPSQMDTNAVPNLSAFQGMLPPVPPGWKPGMPVQLPIDLPLPPPGWKPGDPVPLPPMDSLQIPRFAEQQMQPHIPQPKQPEVIQVQPVNLDLGGSDSDYSSDDASSYDED |
Length | 387 |
Position | Middle |
Organism | Vigna radiata var. radiata (Mung bean) (Phaseolus aureus) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade>
NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.420 |
Instability index | 69.89 |
Isoelectric point | 4.64 |
Molecular weight | 42311.47 |
Publications | PubMed=25384727
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP23058
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 87.36| 18| 18| 301| 318| 1
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301- 318 (40.43/18.61) PPGWKPGMPVQL.P.ID.LP............L
320- 351 (22.07/ 6.95) PPGWKPGDPVPL.PpMDsLQiprfaeqqmqphI
352- 369 (24.87/ 8.73) PQPKQPEV.IQVqP.VN.LD............L
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.32| 18| 21| 21| 38| 2
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10- 27 (30.28/11.99) PARLGLANPNSPSIPNPT
28- 45 (34.04/14.44) PPKLPPTQTQQPQDRNSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.52| 28| 38| 138| 165| 5
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138- 165 (45.98/30.31) DLQDAKQKMDREIRSQDSMLLA.FSNKLK
177- 205 (42.54/27.54) DYSDYRRSKRSKSGDDDSMTSStVSSQLK
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