<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23053

Description mediator of RNA polymerase II transcription subunit 15a isoform X2
SequenceMDNNNWRPNQSNEANMDTSDWRGGLQQESRQRIVNKIMDTLKRHLPVSGQEGLHELQKIAQRFEEKIFTAATSQSDYLRKISLKMLTMETKSQGSMANAPNQGGPSNKPPDPGLVIPPQVHNPGQQHSIPMPNQSQARQQLMQNNIASQSSGLTQTPIQNVGQNNPNMQNIPGQNSVGNTISQNSNMQNMFAGSQRQIQARQQVVPQQQQQSQNSQQFLYQQQIQHQLIRQKFHQQQQQQQNLLQPNQLQSSQQPVIQTSSVMQQAPMMQTSLPSIQHNQQSNNVQQSTQSVLQQHSQVIRQQQPQQTSIIHQQQTPMTQQSILPPQQQQQQQLMGAQGNASNMQHTQILGTQSNNVSDLQQPQQRLLAQQNNLSNLQQQQLINQQNNLSNMHQQLGNNVPGLQPQQVLGPQSGNSGMQTSQHSAHVLQQSQVQIQSQSQPNASNLLPSQVQQSQTQAPQHQLMPQIQSQPAQLQQQLGLQQQPNSLQRDMQQRLQASGPLLQQSTVLDQQKQLYQSQRPLPETSSTSLDSTAQTGQSSGGDWQEEVYQKIKSMKESYLPELNEMYQKIASKLQQDSLPQQPKSEQLDKLKVFKMMLERIITFLQVSKSNISLSPSFKEKLGSYGKQIINFINTNRPKKNIPGQLPPPHMHSMSQSQSQVTQVQSHENQINSQLQTSNMQGSVATMQQNNMPNMQHNSLSGVSTAQQSKMNSMQPNSNLDSGPGNAVNSLQQVPVSSLQQNPVSAPQQTNVNSLSSQSGVNVIQSNLNPLQQGSSMLQHQQLKQQEQQMLHNQQIKQQYQRQLIQRKQQQIMQQQQQQQLHQTAKQQLPAQLPTHQLQQLHQMNDANDIKMRQGIGVKPGVFQSHLTSSQRSSYPHQQMKGSPFPVSSPQLLQATSPQIPQHSSPQVDQQNHLPSLTKVATPLQSANSPFVVPTPSPPLAPSPMPGDSEKPISGVSLISNAANIGYQQSSGATAPAQSLAIGTPGISASPLLAEFTGPDGALGNAFVSTSGKSTVTEQPIERLIKAVKSMSSKTLCSAVSDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVAMTNCRLQARNFIAQDGANGTRRMKRYTYATPLNVVSSAGSMNDSIKQLTASEVSDLDSTATSRFKMPRVEANHSLLEEIREVNQRLIDTVVDISNEEVDPTAAAAAAEGTEGTIVKCSYNAVALSPSLKSQYASVQMSPIQPLRLLVPTNYPNCSPILLDKFPVESGKENEDLSVKAKSRFSISLRSLSQPMSLGEIARTWDVCARTVISEHAQQSGGGSFSSKYGTWENCLTT
Length1305
PositionTail
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.03
Grand average of hydropathy-0.772
Instability index71.22
Isoelectric point9.38
Molecular weight143777.94
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23053
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.36|      24|      27|     188|     214|       4
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  188-  214 (41.49/14.07)	QNMFAGSQRQIQARQqvvPQQ..QQQSQN
  313-  334 (32.87/ 6.03)	QQQTPMTQQSILP.....PQQ..QQQQQL
  390-  415 (33.00/ 6.09)	SNMHQQLGNNVPGLQ...PQQvlGPQSGN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     704.22|     145|     164|     604|     765|       6
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   97-  183 (68.13/11.22)	................................AN...............APNQGGPSNKPPdpglvipPQVHNP.GQ.QHSIPMPNQSQARQ......QLMQNNIASQ.................sSGLT...QT.....PIQ...NVgQN...NPNMQNIP....GqNSVgNTISQ.......................................
  219-  288 (59.21/ 8.65)	...................................................................................................LYQQQIQHQ...........lirqkF.HQ....QQQ.....QQQ...NLlQP...N.QLQSSQ....Q.....PVIQT..SSVMQQAPM...M..QTSLPSIQhNQ...QSNNVQQS
  604-  765 (219.83/56.74)	LQVSKSnISLSPSF..KEKLGSYGKQIINFINTN...............RPKKNIPGQLPP.......PHMHSM.SQ.SQSQVTQVQSHENQIN...SQLQTSNMQGSvatmqqnnmpnmqhnsL.SGVSTAQQS.....KMN...SM.QP...NSNLDSGP....G.NAV.NSLQQVPVSSLQQNPVSAPQ..QTNVNSLS.SQ...SGVNVIQS
  770-  909 (140.42/32.17)	LQ.......QGSSMlqHQQLKQQEQQM...L...hnqqikqqyqrqliqRKQQQIMQQQQQ.......QQLH....Q.TAKQ.........QLP...AQLPTHQLQ.Q................L.HQMNDANDI.....KMRqgiGV.KPgvfQSHLTSSQ....R.SSY.PH.QQMKGSPF...PVSSPQllQATSPQIP.QH...SSPQVDQ.
  910- 1044 (132.86/29.88)	................QNHLPSLTKVATPLQSAN...............SP.FVVPTPSPP.......LAPSPMpGD.SEKPISGVSLISNAAN...IGYQQS.......................SGATAPAQSlaigtPGI...SA.SP...LLAEFTGPdgalG.NAF.VSTS..GKSTVTEQPIERLI..KA.VKSMS.SKtlcSAVSDIGS
 1046- 1146 (83.76/15.85)	VSMNDR.IAGSAPG..NGSRAAVGEDLVAMTNCR...............LQARNFIAQDGA.......NGTRRM.KRyTYATPLNVVSSAGSMNdsiKQLTASE....................V.SDLDSTATS...rfKMP...RV.EA...NHSL..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.40|      16|      16|     545|     560|       8
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  545-  560 (28.86/19.16)	EEVYQKIKS.MKESYLP
  563-  579 (23.54/14.06)	NEMYQKIASkLQQDSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.81|      16|      16|     463|     478|       9
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  368-  382 (23.03/ 6.02)	LAQQ.NNLSNLQQQQL
  463-  478 (28.00/ 9.57)	LMPQIQSQPAQLQQQL
  480-  495 (26.78/ 8.70)	LQQQPNSLQRDMQQRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.23|      18|      19|     500|     517|      10
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  500-  517 (32.41/15.55)	PLLQ.QSTVLDQQKQLYQS
  520-  538 (27.83/12.24)	PLPEtSSTSLDSTAQTGQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.69|      15|      21|      56|      74|      11
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   56-   74 (19.93/25.16)	LQKIAQrfeeKIFTAAT.SQ
   78-   93 (21.75/13.82)	LRKISL....KMLTMETkSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.96|      44|      47|    1195|    1238|      14
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 1195- 1238 (77.08/42.87)	LSPSLKSQYASVQMSPIQPLRL.LVPTNYPNCSPILLDKFPVESG
 1244- 1288 (68.88/37.51)	LSVKAKSRFSISLRSLSQPMSLgEIARTWDVCARTVISEHAQQSG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23053 with Med15 domain of Kingdom Viridiplantae
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