<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23020

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMMDLAYVCEWERWTKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWEVHSISSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSQVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVAAADGSSASPVKFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSTPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLAEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLVSLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEGLVDECCLLPSQLLVPSLDWLPASDGLVSRLQPKQPLRLRFGRAPTLPSNTSTLQLDGLARAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKATAVKQWEQRWIKNCLCGGLWRRVPSAVPESPRRAPLSCA
Length840
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.007
Instability index51.57
Isoelectric point8.33
Molecular weight93146.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23020
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.44|      47|     187|      72|     120|       1
---------------------------------------------------------------------------
   72-  118 (84.82/54.90)	AITCLEW...DQSGSRL.L..SADADGQIKCWSM.ADHL..AN.SWESSV....GSQVEGD
  122-  167 (43.50/30.04)	...ALSW...LHNGVKLaL..HVEKSGAS...SF.GEKF..SRvKFSPSLtlfgGKPMEG.
  268-  320 (56.12/32.18)	AITHLKFlarDMSEQVL.LcaSSQTSSLVECWSLrKEGLpvNN.IFQ.QI.....SPVVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.64|      51|      96|     403|     457|       2
---------------------------------------------------------------------------
  403-  457 (85.00/68.62)	DEPALKRPRTTgpavHFKAMQLSWTSLALVGI....DNHGKLSMLRISPSLGHPLEPKL
  502-  556 (82.64/56.28)	QKPALQQVLST....RILAMKASLCKLSPCTVarvcDYHTKLFLMAITSTLKSLLRPHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.31|      15|      32|     731|     745|       3
---------------------------------------------------------------------------
  731-  745 (30.34/17.26)	QPK.QPL.RLRFGRAPT
  764-  780 (21.97/10.63)	QPKiDHLrRLHLGAYPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.11|      18|      35|     708|     725|       4
---------------------------------------------------------------------------
  708-  725 (33.50/23.83)	LPSQLLVPSLDWLPASDG
  746-  763 (31.61/21.98)	LPSNTSTLQLDGLARAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      17|     140|     187|     231|       5
---------------------------------------------------------------------------
  169-  185 (27.43/36.69)	IAVTVSGLVTV........SLLKPS
  207-  231 (23.76/17.21)	IAFTGGGNIVVaaadgssaSPVKFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.72|      19|     795|       9|      27|       7
---------------------------------------------------------------------------
    9-   27 (42.05/26.67)	EWE.RWTKSTYCPSL...............PLACA
  806-  840 (28.67/15.64)	QWEqRWIKNCLCGGLwrrvpsavpesprraPLSCA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23020 with Med16 domain of Kingdom Metazoa
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