<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23019

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLDNHQLIPPGGGGSSGSASAPAPQPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELLVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQEMKAILRNFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQTTLEDMEKCVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADREDSPVMALLLQQFKDNIQDLISYTKTGKQTRTGTKHKLSDDPCPVECKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPAPCSTSTQPSVTLAASTSQQSASSRTEVSGFYSRCYWLIIIQRNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1493
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.175
Instability index52.05
Isoelectric point8.84
Molecular weight165156.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.86|      28|      32|      77|     107|       1
---------------------------------------------------------------------------
   77-  107 (41.46/37.02)	VERKIEIVQFASRTRQLFV....RLLALvkwANDA
  110-  141 (42.41/27.81)	VEKCAMISSFLDQQAILFVdtadRLASL...ARDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.99|      32|      33|    1091|    1122|       2
---------------------------------------------------------------------------
 1032- 1059 (42.23/15.00)	SPS.MIHTQ..SPAPCSTSTQ......PS...VTLAASTS
 1091- 1122 (64.21/26.67)	SPSGALRAP..SPASFVPTPP......PSSHGISIGPGAS
 1125- 1157 (35.57/11.46)	SPHGTLDPS..SPYTMV.SPSgragnwPGSPQVS.GP...
 1158- 1181 (29.99/ 8.50)	..SPAARLPgmSPAN............PSLH..SPIPDAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      29|    1365|    1390|       3
---------------------------------------------------------------------------
 1365- 1390 (43.68/30.49)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1394- 1419 (39.36/21.02)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      29|    1441|    1450|       4
---------------------------------------------------------------------------
 1441- 1450 (17.56/11.12)	PRQQNSSVAA
 1467- 1476 (19.77/13.64)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.21|      14|      29|     166|     179|       6
---------------------------------------------------------------------------
  166-  179 (26.56/14.21)	RLPTCIRDKII....PPD
  192-  209 (19.65/ 8.60)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      29|     357|     368|       7
---------------------------------------------------------------------------
  357-  368 (20.47/12.69)	IKIDENDVSKPL
  388-  399 (20.28/12.50)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.83|      30|      33|     265|     297|       9
---------------------------------------------------------------------------
  266-  297 (51.79/41.43)	SMQIDFIHQlvQSRLFADEK...PLQ.DMYNCLHCF
  300-  333 (41.04/21.43)	SLQLEVLHS..QTLMLIRERwgdLVQvERYHAGKCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      38|    1286|    1300|      10
---------------------------------------------------------------------------
 1286- 1300 (21.47/20.29)	LKCRVALSP.KTNqTL
 1324- 1338 (22.14/14.22)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.85|      28|      34|     507|     538|      11
---------------------------------------------------------------------------
  507-  538 (42.20/34.19)	IKHLPT..ITTETLQLSNYSTHpignLSKNKLFI
  540-  569 (45.65/26.31)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.07|      12|      38|     441|     452|      12
---------------------------------------------------------------------------
  441-  452 (23.64/15.36)	LEPCGNSECLHI
  476-  487 (22.43/14.19)	MEKCVNDDMKRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.51|      19|      33|    1193|    1211|      15
---------------------------------------------------------------------------
 1193- 1211 (38.84/22.31)	MPTNM............PPPRKLP..QRSWAAS
 1212- 1244 (22.66/ 9.46)	IPTILthsalnilllpsPTPGLVPglAGSYLCS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23019 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPAPCSTSTQPSVTLAASTSQQSASSR
1089
968
1209
1066










Molecular Recognition Features






MoRF SequenceStartStop




NANANA