<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23014
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGGPAVRISIESSCEKQVQEVDFHGTETYVPPLSMSQNLTKLAQRIDFSQGSDSEEDGADGEPRDREWGKQETEEEEGTVKFQPSLWPWDSVRNNLRSALTEMCVLHDVLSVVKEKKYMALDPVSQDPNTPQVFQLISKKKSLATAAQLLLKGAEKLSKSVAENQENRRQRDFNAELLRLRSQWKLRKVGDKILGDLSYRSAGSLFPHPGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFRRTQKSKAGPPWHVKLEAAQNVLLCKEIFAQLSREAVQIKAQIPHIVVKNQIISQPFPGLQLSISLCHSTGEKKSSRASPEKPKPDDHLYVLEHNLHQMMREFHKQQLSSVVMPHPASAPFGHKRLRLAGPMAYDKAEISSLQQSEGLLEKIIKQAKHIFLRSRSIQLQLNIGVEQIRVVHRDGRVVTLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGEYAISVRNGPESGCKVLVQFPRSQIKELPKSDVVQDAKWSQLRGPHKEVNWSKMEGRNFVYKMELLMAALTPCP |
Length | 593 |
Position | Head |
Organism | Poecilia reticulata (Guppy) (Acanthophacelus reticulatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae>
Poecilia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.479 |
Instability index | 53.56 |
Isoelectric point | 8.46 |
Molecular weight | 66519.25 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP23014
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 273.88| 66| 66| 285| 350| 1
---------------------------------------------------------------------------
223- 283 (78.37/47.97) .......LDKKIPEDYCPLDVQIPSDLegsAYIKVSIQKQAPDIGD..LG.TVNLFRRTQKSKAGPPWH...VK
285- 350 (104.60/66.51) EAAQNVLLCKEIFAQLSREAVQIKAQI...PHIVVKNQIISQPFPG..LQLSISLCHSTGEKKSSRASP...EK
352- 419 (90.90/56.83) KPDDHLYVLEHNLHQMMREF..HKQQL...SSVVMPHP.ASAPFGHkrLRLAGPMAYDKAEISSLQQSEgllEK
---------------------------------------------------------------------------
|