<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP23009

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCDWEKRPKSTHCPSVPLVSSWSCRNLVAFTTDLKNDDDDTKDVSHMIHIIDTEHPWDVFSINSGHSEVISCLEWDQSGSRLLSADGDGRIRCWSMSEHLVNSWESALSSSVDGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRRDKYPAVTHLKFLTRENSEQVLLCASNQSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTGDLERVSAVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGAAQRPGDDAAAAIKRPRTTGPALHFKALQFSWTSLALAGVDGHGKLHMLRVSPSMGQVLDMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPSMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSAVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTAMSDNQDSMQLLFRLLTKLWLCSRDDGPPQEPDESLIDECCLLPSQLLVPSMDWLPVNDGIIVKLQGKLPLRLQFGKASSLQGAGGSAPLDVFTRSPGAQKMDNLRCIHMGVSPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRMAPSFT
Length833
PositionTail
OrganismPoecilia reticulata (Guppy) (Acanthophacelus reticulatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.07
Grand average of hydropathy-0.019
Instability index48.54
Isoelectric point7.93
Molecular weight91806.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP23009
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.71|      52|      78|     210|     265|       1
---------------------------------------------------------------------------
  210-  265 (77.05/63.81)	AFTGGGNIVVAATDGSSSSPV.QFYKVVVSVVSEKcriDTELLPSLFLRCTTDpLRR
  289-  341 (87.65/57.62)	ASNQSGSIVECWSLRKEGLPVnNIFQHRSPVVGEK...QPTILKWRILTTTGD.LER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.06|      38|     319|     426|     466|       2
---------------------------------------------------------------------------
  426-  466 (55.54/42.77)	LQFSWTSlALAGVDGHGKLHMLRVSPSmGQVLDmNTTLRHL
  742-  779 (69.52/39.27)	LQFGKAS.SLQGAGGSAPLDVFTRSPG.AQKMD.NLRCIHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.67|      12|      95|     599|     610|       4
---------------------------------------------------------------------------
  599-  610 (22.82/12.88)	DGPPLQSLQQLI
  695-  706 (23.85/13.80)	DGPPQEPDESLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.66|      23|      31|     633|     657|       8
---------------------------------------------------------------------------
  633-  657 (39.60/30.05)	PGFGFMRDG.ASLGMLREMLvmIRIW
  666-  689 (38.07/22.34)	PTFTAMSDNqDSMQLLFRLL..TKLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP23009 with Med16 domain of Kingdom Metazoa
Unable to open file!