<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22989
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | VMELAYVCEWDKRQKSTHCPSIPLVCSWSCRNLVAFTTDLKNEEEDKDVSHMIHIIDTEHPWDVYSISSGHSEVISCLEWDHSGSRLLSADGNGQIKCWAMSDHLVNSWESVLSSSLEGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSMTLFGGKPMEGWLAVTVSGLVTVSLMKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSTSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRKEKYPSVTQLRFLTRENSEQVLLCASNHSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTNDLERVSAVALPKLPISISNTDLKVFCCLRLALAFHDGSIQILHRLSLHTMGVFHGLSSNQRPGDEAVIKRQRTGGPALHFKALQFSWTSLALAGVDNHGKLHMLRVSPSMGQVLDMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPTMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLMAISSTLKSLLRPLVLNMPDKSPGDRLSEICSKNTDTDIDKVMLNLKTEEFVLDGPPLQSLQQLIQWVADFVLYLLANLPNQGSMVRPGFGFMRDGASLGLLREMLVMIRIWGLFKSGCLPTFTAMSDNQDSLQLLFRLLTRLWLCSRDDGPAQEPDESLIDECCLLPSQLLVPALDWLPINDGIIVKLQGKHPIRLQFGKAVSLTSSSQKVDNLRCVHMGVSPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRIPPAPPT |
Length | 814 |
Position | Tail |
Organism | Cynoglossus semilaevis (Tongue sole) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Carangaria> Pleuronectiformes> Pleuronectoidei> Cynoglossidae>
Cynoglossinae> Cynoglossus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.007 |
Instability index | 46.25 |
Isoelectric point | 8.07 |
Molecular weight | 90540.15 |
Publications | PubMed=24487278
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | |
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP22989
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.18| 17| 17| 743| 759| 1
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743- 759 (30.14/19.70) SLTSSSQKVDNLRCVHM
762- 778 (33.04/22.34) SPTEESKACTRCGCVTM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 67.81| 13| 19| 70| 82| 2
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70- 82 (26.70/15.91) GHSEVISCLEW...DH
92- 104 (17.92/ 8.25) GNGQ.IKC..WamsDH
117- 129 (23.18/12.84) LEGDPIVALSW...LH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.97| 24| 90| 273| 301| 5
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273- 296 (43.21/35.10) QLRFLTRENS.EQV..................LLCA.....SNHSGSI
329- 376 (25.77/ 8.20) KWRILTTTNDlERVsavalpklpisisntdlkVFCClrlalAFHDGSI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.63| 15| 19| 629| 644| 7
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604- 618 (23.34/11.37) IQWVADFV.LYLLANL
629- 644 (21.29/14.56) FGFMRDGAsLGLLREM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.34| 16| 17| 426| 441| 8
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426- 441 (27.97/17.56) SLALAGV.DNHGKL.HML
444- 461 (20.37/10.81) SPSMGQVlDMNTTLrHLL
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