<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22989

Description Mediator of RNA polymerase II transcription subunit 16
SequenceVMELAYVCEWDKRQKSTHCPSIPLVCSWSCRNLVAFTTDLKNEEEDKDVSHMIHIIDTEHPWDVYSISSGHSEVISCLEWDHSGSRLLSADGNGQIKCWAMSDHLVNSWESVLSSSLEGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSMTLFGGKPMEGWLAVTVSGLVTVSLMKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSTSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRKEKYPSVTQLRFLTRENSEQVLLCASNHSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTNDLERVSAVALPKLPISISNTDLKVFCCLRLALAFHDGSIQILHRLSLHTMGVFHGLSSNQRPGDEAVIKRQRTGGPALHFKALQFSWTSLALAGVDNHGKLHMLRVSPSMGQVLDMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPTMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLMAISSTLKSLLRPLVLNMPDKSPGDRLSEICSKNTDTDIDKVMLNLKTEEFVLDGPPLQSLQQLIQWVADFVLYLLANLPNQGSMVRPGFGFMRDGASLGLLREMLVMIRIWGLFKSGCLPTFTAMSDNQDSLQLLFRLLTRLWLCSRDDGPAQEPDESLIDECCLLPSQLLVPALDWLPINDGIIVKLQGKHPIRLQFGKAVSLTSSSQKVDNLRCVHMGVSPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRIPPAPPT
Length814
PositionTail
OrganismCynoglossus semilaevis (Tongue sole)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Cynoglossidae> Cynoglossinae> Cynoglossus.
Aromaticity0.07
Grand average of hydropathy-0.007
Instability index46.25
Isoelectric point8.07
Molecular weight90540.15
Publications
PubMed=24487278

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22989
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.18|      17|      17|     743|     759|       1
---------------------------------------------------------------------------
  743-  759 (30.14/19.70)	SLTSSSQKVDNLRCVHM
  762-  778 (33.04/22.34)	SPTEESKACTRCGCVTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.81|      13|      19|      70|      82|       2
---------------------------------------------------------------------------
   70-   82 (26.70/15.91)	GHSEVISCLEW...DH
   92-  104 (17.92/ 8.25)	GNGQ.IKC..WamsDH
  117-  129 (23.18/12.84)	LEGDPIVALSW...LH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.97|      24|      90|     273|     301|       5
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  273-  296 (43.21/35.10)	QLRFLTRENS.EQV..................LLCA.....SNHSGSI
  329-  376 (25.77/ 8.20)	KWRILTTTNDlERVsavalpklpisisntdlkVFCClrlalAFHDGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.63|      15|      19|     629|     644|       7
---------------------------------------------------------------------------
  604-  618 (23.34/11.37)	IQWVADFV.LYLLANL
  629-  644 (21.29/14.56)	FGFMRDGAsLGLLREM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.34|      16|      17|     426|     441|       8
---------------------------------------------------------------------------
  426-  441 (27.97/17.56)	SLALAGV.DNHGKL.HML
  444-  461 (20.37/10.81)	SPSMGQVlDMNTTLrHLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22989 with Med16 domain of Kingdom Metazoa
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