<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22978

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCEWEKRPKSTHCPSIPLVCSWSCRNLVAFTTDLKSEDDDKSTQTNTHTHTHTHTQVNTQTHAELDVLFSDVSHMIHIIDTEHPWDVFSINSGHTEVISCLEWDQSGSRLLSADGDGQIKCWSMSDHLVNSWESVLSSSLDGDPIIALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRREKYPAVTHLKFLTRENSEQVLLCASNQNGSIVECWSLRKEGLPVNNIFQHCSPVVGEKQPTILKWRILTTTSDLERVSAVALPKLPISISNTELKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGASSAQRPGDESAIKRQRTAGPTVHFKALQFSWTSLALAGVDNHGKLHMLRVSPSMGQVLEMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPSMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNTDTDIDKVMLNLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTATSDNQDSMLLLFRLLTKLWLCSRDDGAPQDPDDSLIDECCLLPSQLLVPSMDWLPVNDGVMVKLQGKHPLRLQFGKASSLPSNAPPTPLEVFNRTPGSQRMDNLRCVHMGVCPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRIPPTFT
Length855
PositionTail
OrganismAstatotilapia calliptera (Eastern happy) (Chromis callipterus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Cichlomorphae> Cichliformes> Cichlidae> African cichlids> Pseudocrenilabrinae> Haplochromini> Astatotilapia.
Aromaticity0.07
Grand average of hydropathy-0.059
Instability index43.64
Isoelectric point7.13
Molecular weight94820.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.28|      27|     103|      74|     118|       3
---------------------------------------------------------------------------
   88-  115 (48.10/67.99)	HPWD.VFSiNSGHTEVISCLEWDQSGSRL
  135-  162 (44.17/17.53)	NSWEsVLS.SSLDGDPIIALSWLHNGVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.59|      44|      55|     266|     313|       6
---------------------------------------------------------------------------
  266-  313 (68.35/54.18)	SVVseKC.RIDTELLP..SLFLRCTtdPLRREKYPAVTHLKFLTRENS.EQV
  323-  370 (66.24/40.65)	SIV..ECwSLRKEGLPvnNIFQHCS..PVVGEKQPTILKWRILTTTSDlERV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.66|      29|      31|     688|     716|       9
---------------------------------------------------------------------------
  688-  716 (51.44/30.18)	PTFTATSDNQDSMLLLFRLL..TKLWLCSRD
  720-  750 (50.22/29.29)	PQDPDDSLIDECCLLPSQLLvpSMDWLPVND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22978 with Med16 domain of Kingdom Metazoa
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