<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22909
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MVASLGRTPAYLQNAGFGIGLPSDENKKRELEEILRTLALKPGRISIEGIERLAKRLGLEMWQEPNKDGGQTVSITGAIIVVDIDFIGNNITQVALSFANTLGTSNDLAPQAASILRNNLQPDKPLMISNLADFANNLERLSKLDKLSQAPALNCFTAITGLYESLSRIYEHEKTVMDGGAVEAMCRGNGRPRMHCNGKVGLSVEYWKERRKMPTGGSGKGKERDVKMDGMDMLEPAEQDDPGDKGTTWRIIIEIDELGAECASLDTVRTSENWVGKNTIKPSDDSMFGDDYIIDWVDPEPSVENLMEVDSARPNARFIARLDPPIVVPLLDEVTIFSSLGLYSPPGQIGATTLDGLLFPQALVPGLPPLTRERKVHLPPHMDPLGRVDPSVNHRYTLHTLKPIYAREVWEIPFGHPRQLGPIFQIFRQYVLLATLLRSCFSPHSNATNNSSGVLTSPPPPPEPTQIQTPSFTPDDLDSFLSTPAPEPPTGSTPIDISLYSDPPTPTLRVIFPSHVVPQRLISLEIEVSRNGGVAARYSIVDSPEQVARQGGVAGMGRNGLVGEDVVARAIEVTEDVGMTAEWLRRIV |
Length | 588 |
Position | Middle |
Organism | Terfezia boudieri ATCC MYA-4762 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes>
Pezizales> Pezizaceae> Terfezia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.265 |
Instability index | 42.37 |
Isoelectric point | 5.10 |
Molecular weight | 64321.50 |
Publications | PubMed=30420746
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22909
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 108.26| 22| 23| 455| 477| 3
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455- 477 (41.22/24.47) LTSPPPPPEPTQIqTPS.FTPDDL
481- 497 (31.74/13.98) LSTPAPEP.PT.....G.STPIDI
499- 521 (35.30/16.36) LYSDPPTPTLRVI.FPShVVPQRL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 350.56| 113| 170| 42| 162| 4
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42- 162 (174.34/122.82) PGRISIEGIERLAKRLGLEMWQEPNKDGGQTVSITGAIIvVDIDFIGNNITQValsfaNTLGTS......NDLAPQAASILRNN.....LQPDkPlMISNL..ADFANNLER.LSKLDKLSQAPALNCFTAITGL
214- 340 (176.22/103.65) PTGGSGKGKERDVKMDGMDMLEPAEQDDPGDKGTTWRII.IEIDELGAECASL.....DTVRTSenwvgkNTIKPSDDSMFGDDyiidwVDPE.P.SVENLmeVDSARPNARfIARLDPPIVVPLLDEVTIFSSL
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