<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22897
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MASGLAVDIAIESLLESEVEEISRDGQEKYVPQLSMSEKLAKLAHKIDFLSDVKGHKEDVDKEDDEKSLVTFQPSLWPWDSVRENLRKSLTEVCVLSDVLNVVRDKKYLVLDPVSQNQATPKPTLSLITKKKGLCNAADILLRGAQRMEDAVKERADNTSRHLGSNAKDFHSELMMLRKRWRLKRTGTSIMGDLTYRSAGSQFRNPGLFEVNKATIAEDKTEQSTPDNRALEVTVGSDLEGAAEIRVAIVESGKDLQIASVRGLMSGCYDNMPTVIPSWQQKLESAQSNLFCKELFMQLSQGAYNTKENRPHFVMANEIRAEIFPGTDLCITYSCRKNSSEENSSKVAHKDKAPRAYSLEYSLHSLLRKQHLKAQSLQTPRPVTAYPMQGGSKRLCLAGASALTTSEVAPNLQSESLLETVLKVSRHKVLQKRAVEVIDDLKSRLNDPCITCHWSTVGSDTNTSATVHITSPEVGHLARSSFQLRVGVRGIRVVSADGENVDLPTHPQDLEDFILSQVCNHRLLVAKSLAQSLGWHVIHCSRHVGTGAKERQGHVGGLMVKSPNGNKAVAVRTGPASGVSVLVRRPQLPNGVAPELLGDMNWGCLGGDFMEVHWSKMPGRTFVQKIFLLLAIEMY |
Length | 635 |
Position | Head |
Organism | Pocillopora damicornis |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Cnidaria> Anthozoa> Hexacorallia> Scleractinia>
Astrocoeniina> Pocilloporidae> Pocillopora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.348 |
Instability index | 45.88 |
Isoelectric point | 8.45 |
Molecular weight | 70206.42 |
Publications | PubMed=30382153
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22897
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 136.70| 40| 158| 421| 461| 2
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421- 461 (65.99/45.26) VLkVSRHKVLQKRAVEVIDDLK.SRLNDPCITCHWSTVGSDT
581- 621 (70.71/44.35) VL.VRRPQLPNGVAPELLGDMNwGCLGGDFMEVHWSKMPGRT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.00| 10| 383| 160| 169| 4
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160- 169 (19.02/14.34) SRHLGSNAKD
541- 550 (18.99/14.31) SRHVGTGAKE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.16| 16| 71| 242| 258| 6
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242- 258 (22.65/22.18) AAEIRVAIVeSGKDLQI
316- 331 (30.52/24.09) ANEIRAEIF.PGTDLCI
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