<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22869

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYTGAAGNTAGFSGAAPGARDTARLEGSPFSSSNYPVSSRRQQQLAPYKLKCDKEPLNNKLGPPDFYPQTPNCPEETLTKEYAQAGYKETVEGIEEAREIVLSQIPHFCKPDVVVKCKELLKKRLRAINESRAQKRKAGQVYGVPLSGSLLIKSGVYPEQRPCNEDTRRKWAEGSLALFTSPTKSQEEALAQPNKRLRSLSEHVPHGYRRKSLFEVLTRYNVPLLRATWFVKVTYLNQLQARPTPNSISAGASDNQRSNQWTKDVVEYLQQILDELCSKEGTVVPPSFREQPSPGLSGTNQIKMKTEASPAGGDGEEPLVHYKWRYMVRLIQWHLTEELLVPSVLIEWLSNQLQERDSVDVLELLLPIVLGLVDTITLSQTYVRMLVELLIRRLNDASVVDSPKRPSVSSVIAELLRYMVLAVPDTFVSLDCFPLPSFVVPDVYGRGALLKITGGGGIASSKRRDAYRYLSCGYAVCSIQKRASDLATVANPSLHVRGAAKVVQALDKALVTGNLSMAYSSLFNDLSDALMEERWIKEVSPCLQSSLMWIGTVELSLICSIFFLCEWATCDYRDCRASPCQNVKFTGRRDLSQIHVAVSILKNKMDELNNLSRSKSSNHIPTNNNVKGSSLNDGFLVAAAVSDSSGLRSNAKNVDEKKDTNDIFESPGPLHDIIVCWLDQHEVSSVAGFTRVDVLIVELIRNGIFYPQAYVRQLIISGITDKNDTMLDVERKRRHHRTLKQLPGSSLFDILEETRTAEEQQLYEMMSTYSSERRLVLSELSCGPSFYASSRGEHTSSSGIRKQSDHTVASGGDKHGRVPEQVEDVKALVSSLLSFTYPHPVESEPCQIKTSFQESSTSTLSQVEIGEAKNGCEDCMRSKGQKLDDGATPFQGFPLIQSDEEDIWWVRKGTKLHDSFNVEPAQKSVKQTSRGRAKVVRKTQSLAQLAAARIEGSQGASTSHVCESKLSCPHHKPNSDGDNVKDFDHTRTANLTEVGKSLKRLRLIERRSVSLWLLKSIRQLVEGNEMTASKTTNSISTLSLQPDDKSVSKWRLGDEELLSVLYVLDTCCDLVSGARFLVWLLAKIRGGLDSSGQPGRSSMHMRNREHQVCQVSEALVFSSLLRYENILLVTDILPDVLSASVNRSSVSATARHPGSAAFAYVRYFLKKYRDVASVARWEKNFRTTCDQRLLAELDNGRSIDGDLVSSSGISAGDEIDEQVRQKLNGRSSRLLQNMKEIVQRQADEVQRSLKEKKVLAAPKSPSSFEKEDSYQISHGIVLGLVECIRQNGGANPDGDLSIVASAVSAVVVNAGHVIAKHLDFAGGNYQGVNSVSNSLNFVRYTLRVHINSLCLLKESLGDRFSRVFEIALAAEASAAVTAAFAPAKIHRNQFQPSPETHDAYGNNTSDLGNSGKGFVGRTAKVAAAVSALVVGAIVHGAVSLERMVAVLKIKDGLDILQLLRGLKTSTNGVSRPTGTFRMENSTEVLAHWFRILLGNCRTVYDGLIADILGESYILALSRLQQTLPLSVIFPPAYSIFAMVLWRRYIFNREDPQLYQSLSNAINDITRHQPFREICFRNTHQLYNLLASDVGDSEFAAMLESHNPDRNSKILPFIPLRARLFLDALVDCNTPITQGDGASEPCDPKDNELKLSERLMQLLDTLQPAKFHWQWVEMRLLLDEQALMEKVAAGKTALESLRSLSPNAEGFALSDSEKGFTEVILSRLLARPDAAPLYSEAVHLLGKLQESLVMDVKWILQGQDAILGRRSTRQQLVHIAQRKGLSTKAQVWKPWGWSSLLSDVIANKTIKRKLEVTSIEEGEVVDDTVDAKRPSKTSSHSVDRSFEGIRSINKYLTEKALAELVLPCIDRSSADIRGILSGDLIKQMGAISEHIKAISRNGAKQAGSVPSGNEMPSSKSSGRKGIRGGSPNIGRRTPVGNDPSPPSASALRAALWLRLQFIIRLLPVIMADRSMRHTLASAILGLLATRMIYEDADLPLPPTNATALRREVDSLLEPPLDVLLDRPGESLFERLLCVLHALLGSCKPSWLKSRSASKSTIRTQRDFSAFDNEAAEGLQSALDHMELPETIRRRIQAAMPILPPSRHPCIQCQPPQLSLAALTPLQSCTSSAGPQQKSSCVSWVPTNVSSRSKAALPSHDPEMEVDPWALLEDGTSCPSTSSGSNGTSGVTGDHANLKACSWLKGTVRVRRTELTYIGSLDDDS
Length2221
PositionKinase
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.06
Grand average of hydropathy-0.291
Instability index49.11
Isoelectric point8.55
Molecular weight245025.13
Publications
PubMed=30683860

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22869
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.60|      24|      26|    1893|    1917|       1
---------------------------------------------------------------------------
 1893- 1917 (39.25/30.27)	KAIsRNGAKQAG.SVPSGNE.MPSSKS
 1921- 1946 (37.35/23.30)	KGI.RGGSPNIGrRTPVGNDpSPPSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.97|      22|      26|    1543|    1565|       2
---------------------------------------------------------------------------
 1543- 1565 (37.31/33.56)	WRRYIFnREDPQLYQSLSNAIND
 1572- 1593 (40.65/30.64)	FREICF.RNTHQLYNLLASDVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.80|      45|      50|    2101|    2149|       3
---------------------------------------------------------------------------
 2101- 2149 (78.86/45.35)	PSRHPCIQCQPpqlsLAALTPLQSCTSSAGPQQKSSCVSWVPTNVSSRS
 2154- 2198 (82.94/40.14)	PSHDPEMEVDP....WALLEDGTSCPSTSSGSNGTSGVTGDHANLKACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.26|      36|      49|     990|    1025|       4
---------------------------------------------------------------------------
  919-  954 (35.01/19.69)	..NVEPAQKSVKqtsRGRAkVVRKTQS.LAQLAAAR..IEG
  990- 1025 (58.14/38.44)	TANLTEVGKSLK...RLRL.IERRSVS.LWLLKSIRQLVEG
 1039- 1075 (54.12/35.19)	TLSLQPDDKSVS...KWRL.GDEELLSvLYVLDTCCDLVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.98|      21|      49|     357|     377|       5
---------------------------------------------------------------------------
  357-  377 (35.05/18.28)	ERDSVD..VLELLLPIVLGLVDT
  406-  428 (30.93/15.30)	KRPSVSsvIAELLRYMVLAVPDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.86|      17|      49|    1372|    1388|       6
---------------------------------------------------------------------------
 1372- 1388 (26.84/20.81)	AEASAAVTAAFAPAKIH
 1421- 1437 (28.02/22.12)	AKVAAAVSALVVGAIVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      18|      19|      54|      72|       8
---------------------------------------------------------------------------
   54-   72 (30.56/24.40)	CDKEPLNNKLGPPDfYPQT
   75-   92 (31.89/19.67)	CPEETLTKEYAQAG.YKET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      14|      19|    1278|    1291|      11
---------------------------------------------------------------------------
 1278- 1291 (24.71/15.37)	IVLGLVECIRQNGG
 1300- 1313 (21.17/12.10)	IVASAVSAVVVNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.90|      41|      54|     777|     818|      12
---------------------------------------------------------------------------
  777-  818 (67.25/47.09)	LVLSELSCGPSFYASSRGEHTSSSgIRKQSDHT...VASGGDKHG
  830-  873 (65.65/40.92)	LVSSLLSFTYPHPVESEPCQIKTS.FQESSTSTlsqVEIGEAKNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.05|      19|      55|    1620|    1641|      13
---------------------------------------------------------------------------
 1620- 1641 (28.65/29.49)	RLFLD..ALVDcntPITQGDGASE
 1676- 1696 (26.40/16.23)	RLLLDeqALME...KVAAGKTALE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.83|      11|      26|    1839|    1849|      14
---------------------------------------------------------------------------
 1839- 1849 (20.08/12.62)	VDRSFEGIRSI
 1866- 1876 (19.75/12.27)	IDRSSADIRGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.39|      12|      27|     875|     887|      15
---------------------------------------------------------------------------
  875-  887 (20.33/19.62)	EDC..MRsKGQKLDD
  903-  916 (18.07/10.69)	EDIwwVR.KGTKLHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22869 with Med12 domain of Kingdom Viridiplantae
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