<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22866

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMDAAAAALGAAPGPGVPPPGAAPGEQQAAPRVERLSAGVQQQLNLEGMRARAVGLYKAISRILEDFDVIARTNPAASPKWQDVLGQFSMVSMELFNIVEDIKNVSKVFVVYPRNVNAENAPILPVMLSSKLLPEMEVEETTKREQLLSGIANLPIPTQIEKIKVRIDMIGSACETAEKVIADCRKSYGLGSRQGTNLVPTLDKAQAAKIQEQEGLLRAAVNYGEGLRVPGDQRQPQSLPSHLVEVLPFGDGAQNVGDNSGGYPKSSSTFAPSGVNTQGNPIQASGGQLLGRPAPSPGGTGTPNFENVSTPPMPYANSPRSGTNMMNTPSPQQHLTPQQQRQKLIQASQQQQQLHAQQQLRPSAAGMLAQVPGQQQMQYNQALSQQFHNRQMQPGRMQPGMAQSQLNQGTQLRSHLGQFAGPANSAMFTAAQASSNSQMMANMPGTMQSQSLMPQMQYGMAGGHPQRSHPSQMLTDQMFGMGATNSSMMGMQQQQQGVYGNMQAGAQNMQQGMVGLQNQAQNPNFPQQRQQNQQ
Length533
PositionHead
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.04
Grand average of hydropathy-0.562
Instability index52.06
Isoelectric point9.14
Molecular weight57237.05
Publications
PubMed=30683860

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22866
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.83|      20|      21|     331|     351|       2
---------------------------------------------------------------------------
  367-  394 (31.01/13.76)	LAQVPGQQQmqynqalsQQFHNRQMQPG
  439-  458 (37.82/14.51)	MANMPGTMQ........SQSLMPQMQYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.39|      19|      42|      57|      78|       3
---------------------------------------------------------------------------
   57-   78 (27.45/29.20)	KAISRIledFDVIAR.TNPAASP
  102-  121 (28.95/20.61)	KNVSKV...FVVYPRnVNAENAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.48|      32|      32|     249|     280|       4
---------------------------------------------------------------------------
  223-  242 (28.32/ 6.72)	.........GEGLRVPGDQR..QPQS...L.PSHL
  243-  274 (42.36/12.97)	.VEVLP..fGDGAQNVGDNSGGYPKSSSTFAPSGV
  275-  305 (45.57/14.40)	NTQGNP.iqASGGQLLGRPA...PSPGGTGTPNFE
  306-  336 (40.23/12.02)	NVSTPPmpyANSPRS.GTNMMNTPSPQQHLTP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.22|      22|      51|     344|     365|       5
---------------------------------------------------------------------------
   35-   54 (27.11/10.15)	LSAGV.QQQLNlEG..MRARAVG
  344-  365 (37.55/17.30)	IQASQQQQQLH.AQQQLRPSAAG
  396-  416 (38.56/17.99)	MQPGMAQSQLN.QGTQLR.SHLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.28|      30|      42|     126|     157|       6
---------------------------------------------------------------------------
  126-  157 (41.71/42.19)	MLSSKL.LPEMEVEETTKREQLLS..GiANLpIPT
  168-  200 (44.57/32.88)	MIGSACeTAEKVIADCRKSYGLGSrqG.TNL.VPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22866 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VNYGEGLRVPGDQRQPQSLPSHLVEVLPFGDGAQNVGDNSGGYPKSSSTFAPSGVNTQGNPIQASGGQLLGRPAPSPGGTGTPNFENVSTPPMPYANSPRSGTNMMNTPSPQQHLTPQQQRQKLIQASQQQQQLHAQQQLRPSAAGMLAQVPGQQQMQYNQALSQQFHNRQMQPGRMQPGMAQSQLNQGTQLRSHLGQFAGPANSAMFTAAQASSNSQMMANMPGTMQSQSLMPQMQYGMAGGHPQRSHPSQMLTDQMFGMGATNSSMMGMQQQQQGVYGNMQAGAQNMQQGMVGLQNQAQNPNFPQQRQQNQQ
220
533










Molecular Recognition Features






MoRF SequenceStartStop




NANANA