<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22865

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGIGAGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLNSHETCFTQTADWLFFMRDDLEKRRAPMFDVPSATEVMLTGVYQRLPRCIEDIGSQNKLSPDEEKRALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVFRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASDNPFTVLYAILHEFCISLAMDTIIRQANVLRQGRWKDAIRSELISDSATGQTGNASLMQLVQDGEFDSTGFKIPGLKVNYWLDGKSTSTAEPDSSPFIRIEAGQEMQIKCQHSSFVLDPFTDKEANLSLDLSCIDVEQLILRAIACNRHTRLLNIQRQLCRNVQISQSPKDVILKRDVAAAKDTNKNAAKKGFSDCFGNEVLQGILPAIQEKTLCKTDQVYQQSQGTLRIPETILHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDASDKTKTNANADAKEAIRCNKINVGQMQVLKNESNTNPFDVKLQALQSILSSTDLMESDIPVQNGIEPLPLLPACSPSFSSIVDEVFEYECGSTAAQNHSLPPSSLSSTSHLNSLSVGIQGINPRAVSPMHDGGGSHTQAINTLKVHPSVSLHSYLPSNFRHIQDVNKSLQLVPSSNNNSNQIPVRSSHSGILGNAVSNHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPTYNTVEADSIQKLVSDLRRLSNARSFACGMRRLIGVKVDDKVDDNELSTEMKPQSVNKSNSDASEKLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSTMPKQGNIPTQGLLSNGSSSSTIHHAPVPSNAAAAHLGSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLSCPQFRPFIMEHVAQGLNALEPNFMNATQASVHLNNNSGAPQTAPGASRLSATPGVSMSRPTSGVANHVAASLSRAGNAMLASSALSSGIGGASVRLTPGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSVSADNTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPQMNVAGGAAWLPYCISVRLRYSFGDNYHIIFLAMDGSHGGRACWLQLEEWERCKQKVARAVETVNGSAVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1500
PositionTail
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index46.19
Isoelectric point8.12
Molecular weight163747.02
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22865
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     327.93|      94|     185|     905|    1010|       1
---------------------------------------------------------------------------
  651-  707 (58.27/27.20)	QGINPRAvSPMHDGGGSHTqaINTLKVhPSVSLHSYLPSNFRHIQD....VNKSL.....QLVPSS...........................................................................
  937- 1065 (135.75/97.28)	QGNIPTQ.GLLSNGSSSST..IHHAPV.PSNAAAAHLGSHNLHAAA....MLSAAGRGGPGLVPSSLLPFDVsvvlrGPYWIriiyrkkfsvdmrcfagdqvwlqpatPPKGGP..S..VGGSLSCPQFRPfimeHVAQGL
 1071- 1172 (133.91/82.95)	NFMNATQ.ASVHLNNNSGA..PQTAPG.ASRLSATPGVSMSRPTSGvanhVAASLSRAGNAMLASSALSSGI.....GGASV..........................RLTPGAglPvhMKGELNTAFIGL....GDDGGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.32|      53|     406|     301|     359|       2
---------------------------------------------------------------------------
  301-  359 (82.62/63.14)	ISDSATGQTGNASLMQLVQDGefDSTGfkipGLK..VNYWLDGKSTSTAEPDSSP.FIRIEA
  716-  771 (81.70/47.36)	VRSSHSGILGNAVSNHLVRPS..TTTG....GLEklITAGSDGASRKRSLSDFLPtYNTVEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.82|      29|     129|     114|     149|       3
---------------------------------------------------------------------------
  114-  149 (46.99/49.25)	FFMRDDLEKRRApmfdvpsATEVMLTGVYQRLPR.CI
  244-  273 (48.82/32.60)	FALGDDIERRMA.......ASDNPFTVLYAILHEfCI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22865 with Med14 domain of Kingdom Viridiplantae
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