<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22858
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MMQSHLPSPARLGLTASSPSLPPNPSPLNPTSSPPHGNLPASATAGAGAAPTLTTSPSLLPLLPPLPRAQSLLQLISSLASNLFELSPNRAAWISAYRGSLPTFLPSASSSPPPLPTPISSTKDALSLLTALQTQLFEAVAELQETLDLQDARARLAREARAKDAALLAFAKKLHEAHHVLDRLVDDYADYRRDPKRPRGAAAADDPEPVSDGDFGASLHSRLKLDDILSYAYRISCTTFAPPEHGAGLPLRGALPPAPQEHEMRASKLYQCADLDVGVPKKPLEAEGITAEVEAMPLYEPPPQEGAPRIPNTLPPMFPKELKPPPGWKPGDPITLPLDDILPAVKGEEPQAPVPQVPVSVRPVAPMGPEPIQVKPVQLDFESSSSDEYSSDVGSSEEDDED |
Length | 402 |
Position | Middle |
Organism | Panicum miliaceum (Proso millet) (Broomcorn millet) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade>
Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.353 |
Instability index | 60.80 |
Isoelectric point | 4.87 |
Molecular weight | 42744.86 |
Publications | PubMed=30683860
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22858
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 203.44| 35| 39| 296| 330| 1
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21- 51 (46.66/12.14) LP.....P.....NP.....SPLNPTSSPPHgnLPASATAG.A.GAAP
60- 95 (41.66/10.15) LPLLP..P.....LPraQSLLQLISSLASNL..F..ELSPNrA.AWIS
296- 330 (70.90/21.84) MPLYE..P.....PP..QEGAPRIPNTLPPM..FPKELKPP.P.GWKP
336- 376 (44.22/11.17) LPLDDilPavkgeEP..QAPVPQVPVSVRPV..AP..MGPE.PiQVKP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.12| 29| 37| 123| 153| 2
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123- 153 (38.74/36.92) KDAlSLLtALQTQLFEAVAELQETL.DLQDAR
163- 192 (46.38/33.13) KDA.ALL.AFAKKLHEAHHVLDRLVdDYADYR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.10| 28| 50| 198| 226| 3
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198- 226 (45.89/28.76) PRGAA.....AADDPEPvSDGDFGAS.LHSRLKLD
243- 276 (43.20/22.65) PEHGAglplrGALPPAP.QEHEMRASkLYQCADLD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.90| 11| 134| 96| 106| 5
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96- 106 (22.78/14.07) AYRGSLPTFLP
232- 242 (23.13/14.39) AYRISCTTFAP
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