<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22845

Description Mediator of RNA polymerase II transcription subunit 16 isoform X2
SequenceMTSSAPPNPSPVPVPVPVPTPTPTPNGTASPPKDQPPPPQQQQQQQQAGGQEELAPADGGGAEAAEAGVVAGVAGEAMEVDGGPGSGDAEAGGVVGVGGGGGAGGGGQQASPATVFRIRLKQSPASLRHKMRVPELCRNFSAVAWCGKLNAIACASETCARIPSSNSSPPFWIPIHILNPERPTECSVFNVKADSPRDFVQFIEWSPRSCPRALLVANFHGRITIWTQPNKGPVNLVRDASSWQCEHEWRQDLSVVTKWLSGVSPYRWLPASSTSSNLKTFEEKFLTQQPQSSVFSSGSVQLHWSQWPSQNSAQPRWFSTSKGLLGAGPSGIMAADAIVTESGALHVAGVPLVNPSTVVVWEVMPGLGNGNQATAKINATSSVPPSLNPPSWPGFAPLAAYLFSLQDYLVSEGAQTKKQTENETTEAASIHCCPVSNFSAYVSPEAAAQSATTTTWGSGVTSVAFDPTRGGSVITVVIVEGQYMSPYDPDEGPSITGWRVQCWESSRQPVVLHPIFGSPTSFGGQPPMQIFWSTRVNKSIPPTEDLKNPQTYVPMPTTSDERSSSECSVDRANRLSFDPYDLPNDVRQLAQIVYSAHGGEVAVAFLRGGVHIFSGPDFDQVDSYHVNVGSAIAPPAFSSSSCCLASVWHDTLKDRTILKIIRVLPPAILSTQTKVNSAAWERAIADRFWWSLLAGVDWWDAVGCTQSAAEDGIVSLNSVIAFLDADFHSLPTMQQRQQHCPNLDRIKCRLLEGTNAQDVRALVLDMQARLLLDMLGKGIESALINPSTLLPEPWQASSDMLSSIEPDKMTVEPALLPNIQGYVDAVLDLASHFITRLRRYASFCRTLASHVGPSSTTGTSRNMVTSPTNSSPSPSNNQGNQGGATSAPGNSQMQEWVQGAIAKISNNSDGAATTTPNPMSGRSSFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCLLFRRRQSPRLLANAQKNQDSAIQKIQHMMNAKTEDSSTTVRSGLGAAKVEDGQAMRGGQFALGAKGPEENPIGKSVRIGSGNAGQGYTSDEVKVLFLILVDLCRRTSTLPHPLPASQVGSNNIIIRLHYIDGNYTVLPEVVEASLGPHMQNMPRPRGADAAGLLLRELELQPPAEEWHRRNMFGGPWSEPDDFGPLDNMPHQKVSGSINPHLSDMEEDYGNSLGVQSLWPRKRRLSERDAAFGLKTSVGLGGYLGVMGSRRDVVTAVWRTGLDGEWYKFIRYMVTGEMKSCFYALP
Length1257
PositionTail
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.07
Grand average of hydropathy-0.269
Instability index53.79
Isoelectric point6.12
Molecular weight135109.74
Publications
PubMed=30683860

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1263.55|     329|     352|     492|     843|       1
---------------------------------------------------------------------------
  138-  519 (400.39/261.42)	RNFSA.....VAWCGKLNaiacasetcARIPSSN..SSPPFWIPIHILNPER.PTECSV.......FNvKADSPRD.......FV.........QFIEWSPRSCPRALLVAN.FHGRITIWTQPnkgpvnlvrdasswqcehewrqDLSVVTKWL....SGVSPyrwlPA.SSTSSNLKTFEEKFLTQQPQSS....VFS.........SGSVQLHWS.QWpSQNSAQPRWFStskgLLgagpSGIMAADAI.VTES........GALHvaGVPLVNpSTV...VV....WEVMPGLGNGN..QATakinatssvppslnppswPGFAPLAAYLF...SLQDY..LVSE.GAQTKKQTENETTEAASIHccPVSNFSayvSPEAAAQSA..TTTTWGSGV..T.SVAFDPTRGGSVITVVIVEGQYM....................spydpdegpsITGwrVQC.WESSRQPVVLHPIFGSP
  520-  872 (505.44/370.72)	TSFGGQPPMQIFWSTRVN.........KSIPPTEDlKNPQTYVPMPTTSDERSSSECSVdranrlSFD.PYDLPND.......VR.........QLAQIVYSAHGGEVAVAF.LRGGVHIFSGP......................DFDQVDSYHVNVGSAIAP....PAFSSSSCCLASVWHDTLKDRTILK....IIRVLPP..AILSTQTKVNSA.AW.ERAIADRFWWS....LL....AGVDWWDAVgCTQS........AAED..GIVSLN.SVI...AFLDADFHSLPTMQQRQ..QHC..................PNLDRIKCRLLeGTNAQDVraLVLDmQARLLLDMLGKGIESALIN..PSTLLP...EPWQASSDM..LSSIEPDKM..TVEPALLPNIQGYVDAVLDLASHFItrlrryasfcrtlashvGPS.........sTTG........TSRN.MVTSPTNSSP
  885- 1206 (357.72/226.40)	TSAPGNSQMQ.EWVQGAI.........AKISNNSD..GAATTTPNPMSG..RS............SFM.PISINTGtfpgtpaVRligdchflhRLCQLLL......FCLLFrRRQSPRLLANA......................QKNQ.DSAIQKIQHMMNA....KTEDSSTTVRSGLGAAKVEDGQAMRggqfALGAKGPeeNPIGKSVRIGSGnAG.QGYTSDEVKVL....FL....ILVDL.....CRRTstlphplpASQ.....VGSN.NIIirlHYIDGNYTVLPEVVEASlgPHM..................QNMPRPR.....GADA...........AGLLLRELELQPPAEEWH..RRNMFG...GPWSEPDDFgpLDNMPHQKVsgSINPHL.............................sdmeedyGNS..........L.G..VQSlWPRKRRLSERDAAFGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.34|      19|      21|      48|      68|       2
---------------------------------------------------------------------------
   50-   68 (34.78/16.75)	G.QEELAPADGG.GAEAAEAG
   72-   92 (25.56/ 6.02)	GvAGEAMEVDGGpGSGDAEAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.83|      13|      17|       7|      21|       3
---------------------------------------------------------------------------
    7-   21 (21.53/15.82)	PNP....SPvPVPVPvPTP
   23-   39 (25.30/10.13)	PTPngtaSP.PKDQP.PPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.91|      24|    1110|      97|     120|       4
---------------------------------------------------------------------------
   97-  120 (44.43/20.44)	VGGGGGAGGGGQQASPAT.VFRIRL
 1209- 1233 (40.48/18.05)	VGLGGYLGVMGSRRDVVTaVWRTGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22845 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSSAPPNPSPVPVPVPVPTPTPTPNGTASPPKDQPPPPQQQQQQQQAGGQEELAPADGGGAEAAEAGVVAGVAGEAMEVDGGPGSGDAEAGGVVGVGGGGGAGGGGQQASPATVFRIR
2) SSTTGTSRNMVTSPTNSSPSPSNNQGNQGGATSAPGNSQ
1
854
119
892










Molecular Recognition Features






MoRF SequenceStartStop




1) FRIRLK
116
121