<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22840

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYTGAAGNIAGFSGAAPGARDTARLDGSPFSSSNYPVSSRRQQQLAPYKLKCDKEPLNNKLGPPDFYPQTPNCPEETLTKEYAQAGYKETVEGIEEAREIVLSQIPHFCKPDVVVKCKEALKKRLRAINESRAQKRKAGQVYGVPLSGSLLIKSGVYPEQRPCNEDTRRKWAEALAQPNKRLRSLSEHVPHGYRRKSLFEVLTRYNVPLLRATWFVKVTYLNQLQARPTPNSISAGASDNQRSNQWTKDVVEYLQQILDELCSKEGTVVPPSFREQSSPGLSGTNQIKVKTEASPAGGDGEEPLVHYKWRYMVRLIQWHLTEELLVPSVLIEWLSNQLQERDSVDVLELLLPIVLGLVDTITLSQTYVRMFVELLIRRLNDASVVDSPKRSSVSSVIAELLRYMVLAVPDTFVSLDCFPLPSFVVPDVYGRGALLKITGGGGIASSKRRDAYRYLSCGYAVCSIQKRASDLATVANPNLQVRGAAKVVQALDKALVTGNLSMAYSSLFNDLSDALMEERWIKEVSPCLQSSLMWIGTVELSLICSIFFLCEWATCDYRDCRASPCQNVKFTGRRDLSQIHVAVSILKNKMDELNSLSRSKSSNRTTNNNVKGSSLNDGFLVAAAVNDSSGLRSNAKNVDEKKDTNDIFESPGPLHDIIVCWLDQHEVSSVAGFTRVDVLIVELIRNGIFYPQAYVRQLIISGITDKNDTMLDVERKRRHHRTLKQLPGSSLFDILEETRTAEEQQLYEMMSTYSSERRLVLSELSCGPSFYASSRGEHTSSSGIRKQNDHTVASGGDKHGRVPEQVEDVKALVSSLLSFTYPHPVESEPCQIKTSFQESSTSTLSQVEIGEAKNGCEDCMRSKGQKLDDGATPFQGFPLIQSNEEDIWWVRKGKKLHESFNVEPAQKSVKQTSRGRAKVVRKTQSLAQLAAARIEGSQGASTSHVCESKMSCPHHKPNNDGDNVKDFDHTRTTNLTEVGKSLKRLRLIERRSVSLWLLKSIRQLVEGNEMTASKTTNSISTLSLQPDDKSVSKWRLGDEELLSVLYVLDTCCDLVSGARFLVWLLAKIRGGLGSSGQPGRSSMHMRNREHQVCQVSEALVFSSLLRYENILLATDILPDFLSASVNRNSVSATARHPGSAAFAYVRYFLKKYRDVASVARWEKNFRTTCDQRLLAELDNGRSIDGDLVSSSGISAGDEIDEQVRQKLNGRSSRLLQNMKEIVQRQADEVQRSLKEKKVLAAPKSPPSFEKEDSYQISHDIVLGLVECIRQNGGANPDGDLSIVASAVSAVVVNAGHVIAKHLDFAGGNYQGVNSVSNSLNFVRHTLRIHINSLCLLKESLGDRFSRVFEIALAVEASAAVTAAFAPAKIHRNQFQPSPETHDAYGNNTSDLGNSGKGFVGRTAKVAAAVSALVVGAIVHGAVSLERMVAALNVKDGLDILQLLRGLKTSTNGVSRPTGTFRMENSTEVSAHWFRILLGNCRTVYDGLIADILGESYILALSRLQQTLPLSVIFPPAYSIFAMVLWRRYIFNREDPQLYQSLSNAINDITRHQPFREICFRNTHQLYNLLASDVGDSEFAAMLESHTPDRNSKILPFIPLRARIFLDALIDCNTLTTTQGDGASEPCDPKDNELKLSERLMQLLDTLQPAKFHWQWVEMRLLLDEQALMEKVAAGKTALESLRSLSPNAEGFALSDSEKGFTEVILSRLLARPDAAPLYSEVVHLLGKLQESLVMDVKWILQGQDAILGRRSTRQQLVHIAQRKGLSTKAQVWKPWGWSSLLSDVIANKTAKRKLEVTSIEEGEVVDDTVDAKRPGKTSSHSVDRSFEGIRSINKYLTEKALAELVLPCIDRSSADIRGILSGDLIKQMGAISEHIKAISRNGAKQAGSVPSGNEMPSSKSSGRKGIRGGSPNIGRRTPVGNDPSPPSASALRAALWLRLQFIIRLLPVIMADRSMRHTLASAILGLLATRMIYEDADLPLPPTNATVLRREVDSLLEPPLDVLLDRPSESLFERLLCVLHALLGSCKPSWLKSRSASKSTIRTQRDFSEFDNEAAEGLQSALDHMELPETIRRRIQAAMPILPPSRHPSIQCQPPQLSLAALTPLQSCTSSTGPQQKSSCVSWVPTNVSSRSKAVLPSHDPEMDVDPWALLEDGTSCPSTSSGSNGSGVTGDHANLKACSWLKGTVRVRRTELTYIGSLDDDS
Length2205
PositionKinase
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.06
Grand average of hydropathy-0.303
Instability index49.42
Isoelectric point8.62
Molecular weight243552.30
Publications
PubMed=30683860

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.59|      43|      49|     961|    1009|       1
---------------------------------------------------------------------------
  967- 1009 (70.92/56.38)	KDFDHTRTTNLTEVGKSLKRLRLIERRSVS.LWLLKSIRQLVEG
 1016- 1059 (69.67/41.84)	KTTNSISTLSLQPDDKSVSKWRLGDEELLSvLYVLDTCCDLVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.97|      24|      50|    2086|    2113|       2
---------------------------------------------------------------------------
 2086- 2113 (41.52/36.85)	PSRHPSIQCQPpqlsLAALTPLQSC..TSS
 2139- 2164 (43.45/27.46)	PSHDPEMDVDP....WALLEDGTSCpsTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.71|      33|      50|     342|     374|       3
---------------------------------------------------------------------------
  342-  374 (55.30/36.76)	ERDSVD..VLELLLPIVLGLVDT.ITLSQTYVRMFV
  391-  426 (47.40/30.32)	KRSSVSsvIAELLRYMVLAVPDTfVSLDCFPLPSFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      18|      19|      54|      72|       5
---------------------------------------------------------------------------
   54-   72 (30.56/28.16)	CDKEPLNNKLGPPDfYPQT
   75-   92 (31.89/22.77)	CPEETLTKEYAQAG.YKET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.71|      27|      27|    1882|    1908|       7
---------------------------------------------------------------------------
 1853- 1881 (33.20/17.00)	RSSADIRG..ILSGDlikQ.MGAISEHIKAIS
 1882- 1908 (46.30/26.94)	RNGAKQAG.SVPSGN...E.MPSSKSSGRKGI
 1909- 1934 (27.21/12.46)	RGGSPNIGrRTPVGN...DpSPPSASALR...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.97|      22|      27|    1527|    1549|       8
---------------------------------------------------------------------------
 1527- 1549 (37.31/27.28)	WRRYIFnREDPQLYQSLSNAIND
 1556- 1577 (40.65/24.90)	FREICF.RNTHQLYNLLASDVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.56|      18|      20|    1693|    1710|      11
---------------------------------------------------------------------------
 1693- 1710 (29.33/18.71)	FALSDSEKGFTEVI..LSRL
 1711- 1730 (25.23/14.95)	LARPDAAPLYSEVVhlLGKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      14|      20|    1262|    1275|      13
---------------------------------------------------------------------------
 1262- 1275 (24.71/17.42)	IVLGLVECIRQNGG
 1284- 1297 (21.17/13.70)	IVASAVSAVVVNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.99|      27|      55|     106|     132|      15
---------------------------------------------------------------------------
  106-  132 (46.45/28.16)	QIPHFCKPDVV.VKCKEAL...KKRLRAINE
  134-  161 (33.30/18.00)	RAQKRKAGQVYgVPLSGSL...LIKSGVYPE
  162-  189 (37.24/21.05)	QRP..CNEDTR.RKWAEALaqpNKRLRSLSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.99|      12|      27|    1172|    1184|      17
---------------------------------------------------------------------------
 1172- 1184 (16.46/13.93)	DQRLLAELdNGRS
 1202- 1213 (21.53/12.64)	DEQVRQKL.NGRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      25|      55|    1338|    1365|      18
---------------------------------------------------------------------------
 1338- 1365 (32.43/32.01)	LKESlGDRF.SRVFEIALAVeaSAAVTAA
 1393- 1418 (37.93/24.80)	LGNS.GKGFvGRTAKVAAAV..SALVVGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.48|      12|      19|     469|     481|      22
---------------------------------------------------------------------------
  469-  481 (15.47/17.78)	RASDLATVANpNL
  491-  502 (20.01/14.70)	QALDKALVTG.NL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22840 with Med12 domain of Kingdom Viridiplantae
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