<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22833

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFLFLPIEPDASTTKERSSKAEQKDALNNIVLSAYLHLQSEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLPGRHSSVSEMAQTAVNKLRVASNGLWVAPCNSEEVAAALSQALRNSLERSLRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTLEFVFAATEEAIFVHVVISARYMRNLCSDDIEKVLTHSPRSVGEGLPVVVAPSGMLGRLVGCCPSDLVRQVYPSKSSAASLPGFTQPTVCQLRGQSYYVEVALGFPAASGDKVSESEHIQIKKEMDSAKDSQLGADGQRKVESPDSLQVLQRTFIYPPEAVLVPMVHQAFVRFSSKRMCLQGLLGGSLWEAWPFWNFSPSSYFQNSSFLGSSRGLGVNSNFLRLRRKKNKCNGTASSISSVSSTSDGSERAVATEGDLLADADSMACRQSDMPSNNDNAGSKMVSKRPRSEITEVSSHAGKDVSENVQNANGQIGRPWGWDDEGVVMDINILLSEFGDFSDFFQEEELDFGEPPGTAESHALVIPASDCGDVTFTDSPSTAMDIPEQRLSPVGFTSLDAFDHQIMAPAQDAVSKVQEPQKDIATPAQSQSLVLSSGRFDYLTKAEAMLTFAPEYAAVEVSVAEMPASLFTNPYLPRSKKPGSSSFSSRVYSYDVTQSSQIEPAGDKPEKPSKLTSGNPLRDVDSSNLYTLVQGRKKESEKNLNSTVMQPSKGETSPPISGVTSFSSSLVSQKKSDSMFNAGYFLLSMKTALATEIECITFQAALCRIRHTLLSLRSKVSAEFNSALSSFMQTDVSTKSELTPKYDIRKKEMMPIRLSSDVEHEIHDRSLMESVGVWRPVVTPKGSNSLEPLSAKNLTGASPSLSMQRQPVMDLLFAMALLVQQSTSFVDISLDMDDGDGSFFWLSLDEQKRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLCAEVSESSMFSLLQSDIRTAIKAAFVNMDGPLSVIDWCRGRSNPAELAASGDAYSFQYSTGDIRESSGTMSIGGDSMSPPQPTISNRGTSELEHQKGYHRVRPTIAVLPSPSVLVGYQDDWLKASVNGLKTWEKAPFEPYASPKPVTYYALCPDIDMLTSAATDFFLQLGTVYEVCKLGTHSPQNSGGQMELSPGKYLSSGLVLVECPDQLKKVGNNYLSPISSISDYLQAFSKHWSVKSFVTSVSRILRDIKLTSSISTNQKESSSGPCTVIYVVCPFPDPCAILQTLVESSVALGYVISSPERERKSLYFQVAKAQNSSASADEASASNVVMLSGFSIPKLVLQIVTIETVLRIDKPSNELAVLKDIAFTVYNKARRIPRAVSTNDMFQSPTYLGRSQSTMMHVTSPAPTLWKECLVPRMSGPTLSRETDFDAPMRSATWDNSWQPARAGGLLDPSKIPDLCAQDDRKYAFEPLFILADPGSVDLNASMESSKSGSDAGGSGVYGSISGSTSDSGVSPLLDGSESDRAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNMRPRDVIITRTGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRQSIPEGIPSNSNGPTLQQQDMTLIQDRNMPSSPNPLYSPHSKASYMKGGLGQSGNKKQILVEQTGMDCSRGSLHLVRSISLVAVSQDHSLHLTCQADLLTRPVSGEGNQGGSGPSSYLEGFTPVKSIGSMPASHSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTAIPLAMGYVVSKAVPPIRRDSAQVTREDRPSVLSISIIDHYGGSIGTGQEKMSRGPGGSNMSKQARNFTQEPSTRDYEMEMHNVLETVAAELHSLSWLTVSPVYTERRTALPFHCDMVLRLRRLLHYADRHLTQPAEKGETA
Length1915
PositionKinase
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.07
Grand average of hydropathy-0.284
Instability index56.76
Isoelectric point5.75
Molecular weight208904.53
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22833
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.55|      23|      54|     407|     429|       1
---------------------------------------------------------------------------
  371-  392 (33.02/16.30)	SSYFQNSSFL.....GSSRGLGVNSNF
  407-  429 (34.19/17.17)	SSISSVSSTS..D..GSERAVATEGDL
  438-  460 (27.66/12.36)	CRQSDMPSNN..DnaGSK..MVSKRPR
  461-  485 (28.68/13.11)	SEITEVSSHAgkD..VSENVQNANGQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.52|      26|      27|     113|     138|       2
---------------------------------------------------------------------------
   85-  109 (27.95/14.85)	.LWLfLPGRHSSV.SEMAQTAV..NKLRV
  113-  138 (43.26/27.59)	GLWV.APCNSEEVAAALSQALR..NSLER
  142-  167 (35.31/20.97)	GLSY.ARFG..DVFTKYNPPTRnqNSFRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.09|      36|      54|     492|     531|       3
---------------------------------------------------------------------------
  492-  531 (54.90/44.56)	DDEGVVMDI.NILLSEFGdFS..DFFQEEELdfgEPPGTAESH
  547-  585 (55.20/31.78)	DSPSTAMDIpEQRLSPVG.FTslDAFDHQIM...APAQDAVSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.47|      31|      54|     855|     885|       6
---------------------------------------------------------------------------
  855-  885 (52.71/29.28)	GSNSLEPLSAKNLTGASPSLSMQRQPVMDLL
  910-  940 (58.77/33.56)	GSFFWLSLDEQKRRGFSCDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.33|     103|     126|    1595|    1720|       8
---------------------------------------------------------------------------
 1595- 1720 (159.36/136.04)	PVQLRQSIPEG.....IPSnsngPTLQQ.QDMTLIQDRNMPSSPNPL.YSPHSKASYMKGGLGQsgnkkqiLVEQTGMDCSRGSLHLVR.......SISLVavsqDH...SLHlTCQADLLTRPvsgegnqGGSGPSSYLEGF
 1722- 1841 (157.97/90.86)	PVKSIGSMPAShsyllVPS....PSMRYlSPATLQLPTCLTSESPPLaHLLHSKGTAIPLAMGY.......VVSKAVPPIRRDSAQVTRedrpsvlSISII....DHyggSIG.TGQEKMSRGP.......GGSNMSKQARNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.30|      72|     729|     232|     313|      12
---------------------------------------------------------------------------
  232-  313 (113.04/94.69)	GCCPS......DLVRqvyP..SKSSAASLPGFTQPTV....................CqlRGQSYYVEValgfpAASGDKVS..........ESEHIQIKKEMDSAKDSQLGADGQRKVE
  941- 1050 (98.26/59.73)	GTCHSkdcagvDLVD...PlcAEVSESSMFSLLQSDIrtaikaafvnmdgplsvidwC..RGRSNPAEL.....AASGDAYSfqystgdireSSGTMSIGGDSMSPPQPTISNRGTSELE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.25|      14|     729|     712|     732|      13
---------------------------------------------------------------------------
   64-   79 (25.83/ 6.77)	NSFVgpWDPSQGEHNP
  714-  727 (27.41/17.43)	NSTV..MQPSKGETSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.31|      50|      56|    1219|    1271|      14
---------------------------------------------------------------------------
 1219- 1271 (83.03/59.88)	QKESSS...GPCTVIYVVCPFPDPCAILQTLVESSValgYVISSPERE...RKSLYFQV
 1275- 1330 (69.28/42.27)	QNSSASadeASASNVVMLSGFSIPKLVLQIVTIETV...LRIDKPSNElavLKDIAFTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.52|      10|     729|     639|     648|      15
---------------------------------------------------------------------------
  639-  648 (20.42/12.27)	LFTNP.YLPRS
 1346- 1356 (15.10/ 6.65)	MFQSPtYLGRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.70|      15|     120|     199|     220|      19
---------------------------------------------------------------------------
  201-  216 (23.12/25.67)	DIEKVLTHSPRSVGeG
 1131- 1145 (29.58/ 7.86)	EVCKLGTHSPQNSG.G
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22833 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSMACRQSDMPSNNDNAGSKMVSKRPRSEITEVSSHAGKDVSENVQNANGQIGRPWG
2) GTGQEKMSRGPGGSNMSKQARNFTQEPSTRDYEMEMH
3) IPEGIPSNSNGPTLQQQDMTLIQDRNMPSSPNPLYSPHSKASYMKGG
434
1819
1602
490
1855
1648










Molecular Recognition Features






MoRF SequenceStartStop




NANANA