<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22819

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELGAMVRLAAEESYLALRELVERSRAEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCRQLASTLSNHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNALVRAKLLETSLPKEISEVSVTDGIANLRVDGEFQVLLTLGYRGHFSLWRLLHMELLVGEKTGPIKLEETRRHALGDDIERRMANTDNPFMILYTVLHELCISLVMDTVIRQANVLRQGRWKDAIKSELISDSSAAQGGNAPVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMLINCLHSSFILDPLTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNVQLSQSPTDVVLKREVNEESLGKKVDGKNFQNSCTNEVLQKEGQGRRSTRSGGDCGWGDKAARVPPARVVEDGRWGGGGGGIEVTSWRSTVSVFVEGGGGSGGREPPETGAGGRGGARHGEHAHRSGRLLLQSSKNILLPSVLLESEEALNKGSLTANEVFLNLRTKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLYGSDFMVMGFPQCANAYYFLIQLDNDLRPVFHLLETQTDGSNSSNADANQVIRFNRIDISRMQISEDEYSVNLFDTGKALQDIEGGSLRPSGNEKLLPLTPSLSSSFSSLVDEVFEHNTSSSTIENQHLPPSSLPSTHLSSFQVGLEGLSGTACLPELGNSIHSDINTSEVTPDVSLNSDLLSSSSGPARISSMPSDCKSGLSSLRSLRGHDISNGSKSLQLVSSEGQGVSGNITTTKLGGPSRKRSLSEIVLNIPSLQQSRISNGLRKRRKASEIMKDGVLSKEYSSGKPLTYGNIFTEENHCVTSAIYASVLRHAVKHCSLCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGRMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEAASVHRLVSDLQRLSNARAFSCGMRRLIGIKVDDKRDEKVTSADTNLHPTRKGSKHRLSEQIRKIFRIEAVGLMSLWFSYVSAPMVHFVVEWEAGNDGCTIHVSPDQLWPHTKFLDDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSFVPKQNNFRAQGQPANDSSSTTMQNVCAPLSPSGVHPNNHNLQSSVLSATGRGGPGLVPSPSLPFDVTVVFRGPYWIRVIYRKIFSVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPSYMSARHSGAQLKANTNTTSGSQQSAPVLNRFHGAHGVATSRPTPNVGNQVPPSFTRAGSAMVASSKFASGIVGHPAHLSPGTNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELATSEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLQEFISLIAWKKSQSQAHADIASAQRVRVELCLEKHHVSDSNDHTESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGEMGQGRLRPVAEMIHKQLQLSLQQLRNGPLSAS
Length1761
PositionTail
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.07
Grand average of hydropathy-0.277
Instability index51.34
Isoelectric point7.32
Molecular weight193039.52
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.83|      29|      39|     463|     496|       1
---------------------------------------------------------------------------
  463-  496 (50.14/44.55)	RSTRSGGDCGWGDKAARVPParvvEDGRwGGGGG
  504-  532 (56.69/34.24)	RSTVSVFVEGGGGSGGREPP....ETGA.GGRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.52|      34|      41|     733|     773|       2
---------------------------------------------------------------------------
  698-  729 (28.57/10.98)	......IEGGSLRPS.GneklLPLTpSLSS........SFSSLVDEV
  733-  773 (55.49/41.91)	NTSSSTIENQHLPPS.S....LPST.HLSSfqvglegLSGTACLPEL
  775-  804 (38.46/17.49)	NSIHSDINTSEVTPDvS....LNSD.LLSS.......SSGPA.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     204.89|      91|     962|     278|     399|       3
---------------------------------------------------------------------------
  281-  320 (31.00/36.51)	.................................................................................................................................................................................................................................................................................................................................................................................................................................................QANVLRQGRWkDAIKSELISDSSAAQGGNAPVQLGQdGEL
  331-  399 (60.11/62.49)	KLNYWldenssgsaepdlspfISIEVGK..DMLINCLHSSFI.LDPLTDKEADLSI..DLSCIDVEALILKAIA...............................................................................................................................................................................................................................................................................................................................................................................................................
 1281- 1338 (67.14/37.11)	RGPYW................IRVIYRKifSVDIRCFSGDQVwLQPATPPKGGPSVggSLPCPQFRPFIMEHVA...............................................................................................................................................................................................................................................................................................................................................................................................................
 1698- 1735 (46.65/14.30)	..........................................................................qglnafepsymsarhsgaqlkantnttsgsqqsapvlnrfhgahgvatsrptpnvgnqvppsftragsamvasskfasgivghpahlspgtnlpvhmkgelssaftglgddggyggawvplaalkkfpellkeilgsvlnenegallnldqeqpalrffvggyvfavsvqraqlllqvlnvkrfhhqqqkqqqqaqspaqeelatseineicdyfsrrvacepydasrvasfitlltlpisvlqefisliawkksqsqahadiasaqrvrvelclekhhvsdsndhtesssssrsnikhdranrsvdfgltfvldhglkhhtniggaawlpycvsvrlrynfgdnghvmflamegshggKACWLQYEDW.ERCKQAVVRAMESANGSPAPGEMGQ.GRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.69|      45|     160|    1199|    1273|       4
---------------------------------------------------------------------------
 1229- 1273 (81.83/84.33)	STTMQNVCAPLSPSGVHPNNHNLQSSVLSATGRGGPG.LVPSPSLP
 1387- 1432 (75.87/31.39)	SRPTPNVGNQVPPSFTRAGSAMVASSKFASGIVGHPAhLSPGTNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.68|      19|     159|     845|     866|       5
---------------------------------------------------------------------------
  848-  866 (32.59/28.59)	NITTTKL....GGPSRKRSLSEI
  869-  891 (26.09/11.30)	NIPSLQQsrisNGLRKRRKASEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.45|      16|      16|     944|     959|       6
---------------------------------------------------------------------------
  944-  959 (27.91/17.19)	QLTTQMDS..LGIPYAEE
  961-  978 (22.55/12.34)	ELGTPSSNlwLRLPFLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.50|      15|      16|     912|     926|       7
---------------------------------------------------------------------------
  912-  926 (26.41/16.69)	IFTEE.NHCVTSAIYA
  928-  943 (23.09/13.66)	VLRHAvKHCSLCIKYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.11|      18|      25|     981|    1002|       9
---------------------------------------------------------------------------
  981- 1002 (29.81/33.49)	WKhvclRLGKTGRMSW..DVRITD
 1009- 1028 (30.30/20.16)	WK....VYGGSTTTEWgiGVRIAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.80|      22|     561|     625|     659|      10
---------------------------------------------------------------------------
  104-  126 (35.82/14.39)	FTQTADSLFFMHDgLQQARAPIF
  625-  646 (41.98/47.17)	FPQCANAYYFLIQ.LDNDLRPVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.58|      44|     963|     573|     621|      14
---------------------------------------------------------------------------
  573-  621 (63.18/59.51)	ANEvflNLRTKSILHLFAATGRFLGLKVFSQSQVT.....LKIPKSVLygSDFM
 1537- 1585 (69.39/48.12)	AQE...ELATSEINEICDYFSRRVACEPYDASRVAsfitlLTLPISVL..QEFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22819 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSCTNEVLQKEGQGRRSTRSGGDCGWGDKAAR
2) RHSGAQLKANTNTTSGSQQSAPVLNRFHGAHGVATSRPTPNVGNQVPPSFT
3) VEGGGGSGGREPPETGAGGRGGARHGEHAHR
448
1352
511
479
1402
541










Molecular Recognition Features






MoRF SequenceStartStop




NANANA