<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22807

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMMQSHLPSPARLGLTASSPSLPPNPSPLNPTSSPPHGNLPASATAGSGAGAAPTLTTSPSLLPLLPPLPRAQSLLQLISSLASNLFELSPNRAAWISAYRGSLPTFLPSASSSPPPLPTPISSTKDALSLLTTLQTQLFEAVAELQETLDLQDARARLAREARAKDAALLAFAKKLHEAHHVLDRLVDDYADYRRDPKRPRGAAAADDPEPVSDGDFGASLHSRLKLDDILSYAHSISCTTFAPPEHGAGLPLRGAFPPAPQEQEMRASKLYQFADLDVGVPKKPLEAKEGITAEVEATPLYEPPPQEGAPRIPSTLPPMFPKELKPPPGWKPGDPITLPLDDILPGVKGEEPQAPVPQAPVSVRPVAPMGPEPIHVKPVQLDFETSSSDEYSSDVGSSEEDDED
Length405
PositionMiddle
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.05
Grand average of hydropathy-0.378
Instability index60.62
Isoelectric point4.92
Molecular weight42944.92
Publications
PubMed=30683860

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     240.75|      46|      47|     282|     327|       1
---------------------------------------------------------------------------
    7-   51 (53.65/13.62)	.PSPARLGLTASS.PSLP....PNPS...PLNP...TSSPPHgnlpasATAGS..GAGA
  244-  283 (60.70/16.35)	.PPEHGAGLPLR..GAFP....PAPQEQEMR.A...SKLYQF......ADLDV..GVPK
  284-  329 (81.40/24.35)	KPLEAKEGITAEV.EATP.LYEPPPQEGAPRIP...STLPPM......FPKEL..KPPP
  332-  379 (45.00/10.28)	KP...GDPITLPLdDILPgVKGEEPQAPVPQAPvsvRPVAPM......GPEPIhvKP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.21|      38|      38|     125|     162|       2
---------------------------------------------------------------------------
   72-   99 (42.97/23.22)	QSLLQLISSLASNLFE...........LSP.....NRAAWISAY
  125-  162 (60.39/35.34)	KDALSLLTTLQTQLFEAVAELQETL.DLQD.....ARARLAREA
  165-  206 (47.86/26.63)	KDA.ALL.AFAKKLHEAHHVLDRLVdDYADyrrdpKRPRGAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.91|      15|      50|      53|      69|       3
---------------------------------------------------------------------------
   53-   69 (26.30/13.92)	PTLTTSPSLLPllPPLP
  104-  118 (31.61/12.32)	PTFLPSASSSP..PPLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22807 with Med4 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKPLEAKEGITAEVEATPLYEPPPQEGAPRIPSTLPPMFPKELKPPPGWKPGDPITLPLDDILPGVKGEEPQAPVPQAPVSVRPVAPMGPEPIHVKPVQLDFETSSSDEYSSDVGSSEEDDED
2) MMQSHLPSPARLGLTASSPSLPPNPSPLNPTSSPPHGNLPASATAGSGAGAAPTLTTSPSLLP
283
1
405
63










Molecular Recognition Features






MoRF SequenceStartStop




1) IHVKPVQLDFET
375
386