<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22801

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAVELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGIGAGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLSSHETCFTQTADWLFFMRDDLEKLRAPMFDVPSATEVMLTGGYQRLPRCIEDIGSQNKLSPDEQKRALRKLDASVRYKVLVTPRPKEVSNVSVTHGIAVLRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASDNPFTVLYAILHEFCISLAMDTIIRQANVLRQGRWKDAIRSELISDSATGQTGNASLMQLVQDGEFDSSGFKIPGLKVNYWLDGKSTSTAEPDSSPFIKIEAGQEMQIKCQHSSFVLDPFTDKEANLSLDLSCIDVEQLILWAIACNRHTRLLTIQRQLCKNVQISQSPKDVILKRDVAAAKDTNKNAGKKGFSDCFGNEVLQVRAYGQAYISLGINIRSGRFLLQSPENILPPAALTDCEETLNKGSTSATEIFQQSQGTLKIPETILHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDASDKTKTNANADAKEVIRCNKINVGQMQVLKNESNTNPFDVKLQALQSIMSSTDLMESDIPVQNGIEPLPLLPACSPSFSSIVDEVFEYECGSTAAHNHSVPPSSLPSTSHLNSLSVGIQGINPRAVSPMHDGGGSHTQAINTLKVHPSVSLHSYLPSNFRHIQDINKSLQLVPSSNNNSNQIPVQSSHSGILGNSVSNHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPSIPSLQGLQPSEPRKRRKISQSVKSPLPLPAYSSNLQSRASLTCGDVHEERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSTLWLRLPFAQDDSWKHICLHLGKAGSMSWDVRINDPHFRELWELNGGSTMTQWGVGIRIANTSEMDSHISFDSDGVVLTYNIVEADSVQKLVSDLRRLSNARSFACGMRRLIGVKVDDKVDDNQLSTEMKPQSVNKSNSDASEKLSEQMRKMFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKGGCTMHVSPDQLWPHTKFLEDFVNGGQVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSTMPKQANIPTQGPLANGSSSSTIHHAPVPSNAAAAHLGSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASVHLNNNAGAPQTAPGASRLSATPGVSMSRPTSGVANHVAASLSRAGNAMLASSALASGIGGASVRLTPGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSVSADNAESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCISVRLRYSFGDNNHIAFLAMDGSHGGRACWLQLEWERCKQKVARAVETVNGSAVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1713
PositionTail
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.06
Grand average of hydropathy-0.164
Instability index49.06
Isoelectric point8.15
Molecular weight186998.50
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     515.22|     137|     394|    1107|    1247|       1
---------------------------------------------------------------------------
 1107- 1247 (224.03/153.87)	NGGQVASFLDCIRLTAGPLLALGGAIRPARMPvtVSSGYSTMPK.QANIPTQGpLAN..GSSSSTIHHAPVPSNAAAAHLGSHNLHAAAMLSaAGRGGPGLVPSSLLPFDVSVVLRGPY...WIRIIYRKKFSVDMRCFAGD................QVWLQ
 1276- 1412 (197.62/122.44)	AQGLNALEPNFMNATQASVHLNNNAGAPQTAP..GASRLSATPGvSMSRPTSG.VANhvAASLSRAGNAMLASSALASGIGG....ASVRLT.PGAGLPVHMKGELNTAFIGLGDDGGYgggWVPLAALKKVLRGILKYLG.................VLWL.
 1562- 1652 (93.57/52.56)	......................................................LEN..HSGSVSADNA..ESSLAKSNIHHDRAHSSVEFA.....LTFVLDHALIP.HMNVA.GGAA...W..LPY..CISVRLRYSFGDnnhiaflamdgshggrACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.05|      48|     393|     123|     238|       2
---------------------------------------------------------------------------
  165-  220 (68.18/130.42)	RALRKLDAsVRYKVLVTPRPKEVSNVSVTHgiavLRVDGEFKvllTLGYR..G.NVDLW
  288-  338 (76.87/21.94)	RQGRWKDA.IRSELISDSATGQTGNASLMQ....LVQDGEFD...SSGFKipGlKVNYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.55|      26|      27|     702|     727|       3
---------------------------------------------------------------------------
  702-  727 (46.64/27.24)	HTQAIN.TL......KVHPSVSLHS.YLPSNFRH
  729-  754 (25.12/11.11)	..QDINkSL......QLVPSSNNNSnQIPVQSSH
  772-  799 (20.79/ 7.87)	TTGGLE.KLitagsdGASRKRSLSD.FLPS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.24|      25|      55|     613|     638|       9
---------------------------------------------------------------------------
  613-  638 (39.89/29.41)	SIMSSTDLMESDIPVQnGIEPLPLLP
  670-  694 (43.35/27.08)	SLPSTSHLNSLSVGIQ.GINPRAVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.59|      22|      23|     911|     933|      11
---------------------------------------------------------------------------
  911-  933 (36.26/25.92)	DDSWKHIcLHLGKAGSMS.WDVRI
  935-  957 (37.33/20.93)	DPHFREL.WELNGGSTMTqWGVGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22801 with Med14 domain of Kingdom Viridiplantae
Unable to open file!