<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22782

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMADKGKVPLVNYSRQLASTLSNHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNALVRAKLLETSVPKEISEVSVTDGIANLRVDGEFHVLLTLGYRGHFSLWRLLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTDNPFMILYTVLHELCISLVMDTVIRQANVLRQGRWKDAIKSELISDSSAAQGGNAPVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMQINCLHSSFMLDPLTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKDVQLLQSPTDVVLKREVNEEGLGKKVDGKNFQNSCTNEVLQVRAYGESYIHLGINIREPPETGVEGSWMMWWGHDMENMLIESEEALNKGSLTANEVFVNLRIKSIFHLFAATGRFSQSQVTLKIPKSVLYGSDFMVMGFPQCANAYYFLIQLDNNLRPVFHLLETQSDESNSSNADANQVIRFNRIDISCMQTGEDEYSVNLFDTGKALQDIEGGSLRPSGNEKLVPLTPSLSSSFSSLVDEVFEHSTSSSTIENQHLPPSSLPSTHLSSFQVGPEGLSGTACLPELRNSIHSDINTSEVTHDVSLNSDLLSSSSGPARISPMPSDCKSGHGLSSLSSLRVHDISHGVLGNISTTKLGGPSRKRSLSEIVLNIPSLQQSRISDGPRKRRKASEIMKDSALSKEYSSGKPLTYGNIFTEENRCVTSAIYASVLRHAIKHCSLCIKDAQLTTQLDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGRMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDEVVLTYHTVEAASVHRLVSDLQRLSNTRAFSCGMRRLIGIKVDDKRDEKVTSAETNLHPTTKGSKHRLSEQIRKFFRIEAVGLMSLWFSYVSAPMVHFVVEWEAGNDGCAIHVSPDQLWPHTKFWEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSSVPKQNNFRAQGQLANDSSSTTMQNVCAPLSPSGAHPNNHNLQSSVLSATGWGGPGLVPSPSLPFDVTLVLRGPYWIRVIYRKIFSVDIRSFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVALGLNAFEPSYMSARHSGAQLKANANTASGSQQSAPALNRFHGAHGVAISRPTPNVGNQVAPSFTRAGSAMVASSKFASGIAGHPAHLSPGTNLHVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELAISEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKSQSQAHGDIASAQRVRVELCLEKHHVSDSSDHAESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGETGQGRLRLVAEMIHKQLQLSLQQLRKGPLSAS
Length1620
PositionTail
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index49.83
Isoelectric point6.51
Molecular weight178555.52
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22782
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.99|      60|     408|     646|     713|       1
---------------------------------------------------------------------------
  505-  576 (81.17/40.97)	QSDESNSSNADAnqviRFNRIDISCmQTGEDEYSVnlfdTGKALQDIEGGSLrpsGNEKLVPL.TPSLSSSFS
  646-  706 (100.82/58.67)	NSDLLSSSSGPA....RISPMPSDC.KSGHGLSSL....SSLRVHDISHGVL...GNISTTKLgGPSRKRSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.68|      42|     213|     913|     976|       2
---------------------------------------------------------------------------
  913-  962 (55.43/54.97)	FSCGMRRLIGikvDDKRDEKVTSAETNlhPTTKGSKHrlSEQIRKFFrIE
 1136- 1177 (79.25/46.95)	FSVDIRSFSG...DQVWLQPATPPKGG..PSVGGSLP..CPQFRPFI.ME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      14|     213|     963|     976|       3
---------------------------------------------------------------------------
  963-  976 (26.75/18.64)	AVGLMSLWFSYVSA
 1180- 1193 (26.21/18.09)	ALGLNAFEPSYMSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.16|      79|     111|     168|     252|       4
---------------------------------------------------------------------------
  168-  252 (120.59/102.56)	GDDIErrMANTDNPFMI..LYTVLHELCISL....VMDTVIRQANVLRQGRWKDaIKSELISDSSAAQggnAPVQLGQDGELDLSGF..RIPG
  280-  366 (109.57/74.37)	GKDMQ..INCLHSSFMLdpLTDKEADLSIDLscidVEALILKAIACNRHTRLLE.IQRELSKDVQLLQ...SPTDVVLKREVNEEGLgkKVDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.09|      34|      39|    1197|    1234|       7
---------------------------------------------------------------------------
 1197- 1234 (48.57/35.88)	GAQLkANANTASGSQQSAPalNRF.HG..AHGVAISrPTPN
 1236- 1272 (53.52/26.48)	GNQV.APSFTRAGSAMVAS..SKFaSGiaGHPAHLS.PGTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.47|      14|     232|    1287|    1300|      11
---------------------------------------------------------------------------
 1287- 1300 (30.15/17.30)	GLGDDGGYGG.AWVP
 1514- 1528 (25.32/13.27)	GLKHHTNIGGaAWLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22782 with Med14 domain of Kingdom Viridiplantae
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