<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22775

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceGELQTVSWFQFLPIELDASTTKERSSKAEQKDALNNIVLSAYLHLQSEGFLSTWTNSFVGPWDPSQGEHNPVASNGLWVAPGNSEEVAAALSQALRNSLERSLRGLSYARFGDVFTKYNPPTRNQNGFRRAQPTVEFVFAATEEAIFVHVVISARYMRNLCSDDIEKVLTHSPRSVGEGLPVVVAPSGMLGRLVGCCPSDLVRQVYPSKSSAASLPGFTQPTVCQLRGQSYYVEVALGFPAASGDKVSESEHIQIKKEMDSAKDSQLGADGQRKVESPDSLPVLERTFIYPPEAVLVPMVHQAFVRFSSKRMCLQGLLGGSLWEAWPFWNFSPSSYFQNSSFLGSSRGLGVNSNFLRLRRKKNKCNGTASSISSVSSTSDGSERAVATEGDLLADADSMACRQSDMPSNNDNAGSKMVSKRPRSEIMEVSSHAGKDVSENVRGANGQVGRPWGLDDEGVVMDINILLSEFGDFSDFFQEEELDFGEPPGTAESHALVIPASDCGDVTFTDSPSTAMDIPEQRLSPVGFTSMDAFDHQIMAPAQDAVSKVQEPQKDIATPAQSQSLVLSSGRFDYLTKAEAMLTFAPEYAAVEVSVAEMPASLFTNPYLPRSKKPGSSSFSSRVYSYDVTQSSQIKPAGDKPEKPSKLTSGNPLHDVDSSNLYTLVQGRKKESEKSLNSTDMQPSMGETSPPISGVTSFSSSLVSQKKSDSMFNAGYLLLSMKTALATEIECITFQAALCRIRHTLLSLRSKASAEFNSTMSSFMQTDVSNKSDLTPKYDIRKKEMMPIRLSSDVEHETHDRSLMESVGIWRPIVTPKGSNSLEPLSAKTLTGASPSLSMQRQPVVDLLFAMALLVQQSTSFVDISLDMDDGDGSFFWLSLDEQKRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLCAEVSESSMFSLLQSDIRTALKAAFVNMDGPLSVTDWCRGRSNPAESASSGDAYSFQYSTGDIREPSSTMSIGGDSMSPPQPTSSNRGMPAVTCSMNLIIPFKNNIAIRVTYYALCPDIDMLTSAATDFFLQLGTVYEVCKLGTHSPQNSGGQMELSPGKYLPSGLVLVECPDQLKKVGNNYLSPISSISDYLQAFSKHWSVQSFVTSVSRILRDIKLTSSISTNKKESSSGPCTVIYVVCPFPDPCAILQTLVESSVALGYVISSPERERKSLYFQVAKAQNSSASADEASASNVVMLSGFSIPKLVLQIVTIETVLRIDKPSNELAVLKDIAFTVYNKARRIPRAVSTNDMFQSPTYLGRSQSTMMHVTSPAPTLWKECLVPRMSGPTLSRETDFDAPMRSATWDNSWQPARAGGLLDPSKIPDLCAQDDRKYAFEPLFILADPGSVDPNASMESSKAGSDAGGSGVYGSISGSTSDSSVSPLLDGSESDRAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNMRPRDVIITRTGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPEGIPSNSNGPTLQQQDMTLIQDRNMPSSPNPLYSPHSKASYMKGGLGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDHSLHLTCQADLLTRPASGEGNQGGSGPSSYLEGFTPVKSIGSMPASHSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTAIPLAMGYVISKAVPPIRRDSAQVTREDRPSVLSVSIIDHYGGSIGTAQEKMSRGPGGSNMSKQARNFTQETSTRDCEMEMHNVLETVAAELHSLSWLTVSPVYTERRTALPFHCDMVLRLRRLLHYADRHLTQPAEKGETA
Length1842
PositionKinase
OrganismPanicum miliaceum (Proso millet) (Broomcorn millet)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum.
Aromaticity0.07
Grand average of hydropathy-0.278
Instability index57.48
Isoelectric point5.65
Molecular weight200172.63
Publications
PubMed=30683860

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22775
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.18|      22|      54|     370|     391|       1
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  370-  391 (37.44/20.25)	SSISSVSSTS..DGSERAVATEGD
  424-  447 (32.73/16.75)	SEIMEVSSHAgkDVSENVRGANGQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.05|      46|      54|      75|     120|       2
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   68-  116 (75.23/43.65)	EHNP..vasNGLW...............................VAPGNSEEVAAALSQALRNSL...ERSLRGLSYARFGDVFT
  117-  170 (65.19/36.82)	KYNPptrnqNGFR...............................RAQPTVEFVFAATEEAIFVHVvisARYMRNLCSDDIEKVLT
  171-  231 (24.63/ 9.23)	.HSP.........rsvgeglpvvvapsgmlgrlvgccpsdlvrqVYPSKSS..AASLPGFTQPTV...CQ.LRGQSY........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.09|      36|      54|     455|     494|       3
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  455-  494 (54.90/52.94)	DDEGVVMDI.NILLSEFGdFS..DFFQEEELdfgEPPGTAESH
  510-  548 (55.20/37.82)	DSPSTAMDIpEQRLSPVG.FTsmDAFDHQIM...APAQDAVSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     384.22|     126|     485|    1077|    1244|       9
---------------------------------------------------------------------------
  186-  296 (70.57/25.94)	PSGMLgrLVgCCPSDL..................................................................................vrqvypskssaaslpgftqptvcqlrgqsyyveVALGFPAAS..GDKVSESEHIQIKKEmdsaKDSQLGADgqrkvESPDSLPVLERTFIYpPEAVL
 1083- 1229 (196.08/180.88)	PSGLV..LV.ECPDQLkkvgnnylspiSSISDYLQAFSKHWSVQSFVTSVSRILRDikltssiSTNKKESSsgPCTVIYVVCpFPDPCAILQTLVESS.................................VALGYVISS..PERERKSLYFQVAKA....QNSSASAD.....EASASNVVMLSGFSI.PKLVL
 1638- 1731 (117.56/58.25)	...........................SGPSSYLEGFTPVKSIGSMPASHSYLLVP.......SPSMRYLS..PATLQLPTC.LTSESPPLAHLLHSK............................gtaipLAMGYVISKavPPIRRDSA..QVTRE....DRPS..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.21|      40|      56|     861|     901|      10
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  861-  901 (72.14/40.77)	FVDiSLDMDDGDGSFFWLSLDEQK...RRGF.SCD.PSMVHAGCGG
  916-  960 (58.07/28.47)	LVD.PLCAEVSESSMFSLLQSDIRtalKAAFvNMDgPLSVTDWCRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.76|      42|     179|    1572|    1616|      12
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 1572- 1616 (61.91/52.09)	MKGGLGQSGNKKQI..LVEQTGMDSSRGSLHLVrsISLVAvSQDHSL
 1752- 1795 (69.84/47.07)	MSRGPGGSNMSKQArnFTQETSTRDCEMEMHNV..LETVA.AELHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.70|      35|     186|    1337|    1380|      14
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 1337- 1380 (51.24/38.02)	GLLDPSKIPDLCAQDdrkyafepLFILAD...PGSVDPNASmESSKA
 1532- 1569 (61.46/27.18)	GIPSNSNGPTLQQQD........MTLIQDrnmPSSPNPLYS.PHSKA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22775 with Med13 domain of Kingdom Viridiplantae
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