<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22771
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDRASSASFRAGPPSPSSPAAGALKQNQLPAPLSDRIPQTPTSPPLMSVSAQNYATNFVSSQASPNQATSQSATLSSPPSSAPMSTQASQQPTVGTANSFPTPASSVSGHFPGATSFDDPENTDKPMGSTVPDTGAQTANMNAAAIQQAEHRRTDHDRHTEGIKMEVGVRDFAANHGGDAMDIDSEAPASSSRSEPSLESLQKNFSSAFHVCKSSHIATGPDPSLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKTEPGAPGSLRHMTMWPEEEWQNQKVFGKEIKVADMDSALHSLQMRAMKMEPGTVPNNEYWEDVLGHEKPSKHAGGDASKKGVAPPPNGVRIPQPNGTPAPVSDQERSRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKDHVSKISTPLPDRGGSYGVGMFGIGAR |
Length | 455 |
Position | Head |
Organism | Aspergillus welwitschiae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.787 |
Instability index | 51.44 |
Isoelectric point | 7.25 |
Molecular weight | 48274.85 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22771
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 192.69| 41| 326| 13| 53| 1
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13- 53 (73.69/31.36) GPPSPSS......PAAGALKQ.NQLPAPLSDRIPQTPTSPPLMSVSAQ
65- 94 (40.26/14.00) SPNQATS......QSA.TLSS.PPSSAPMSTQASQQPT..........
100- 146 (49.51/18.80) SFPTPASsvsghfPGATSFDDpENTDKPMGSTVPDTGAQTANMNAAA.
360- 380 (29.23/ 8.27) .........................PPPNGVRIPQ.PNGTP.APVSDQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.93| 11| 14| 394| 404| 5
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394- 404 (21.72/13.22) DDNSFVGYGEG
410- 420 (21.21/12.75) DDGAFYSNSEG
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