<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22766

Description Uncharacterized protein
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEEAQQAQQAAPSAGTNGGPASPTAAGVNGGSSTTPGSPSGAAGGAASGSATIASPDAIEPREVILAPFGLAGTLTGQSYKTSDPHVQKMLDDWSAFYPISNKLSSMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSVNETRSNSSSNSNSSSNSNHNNSNQTATPATVIPSIAATVLSRANNASERSSGPINTTSNQPATGTIGSSNSPSMARNKDTAHETSSVAASPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSAAVILPERVWQDCIMHAAPSPSPSMSSSSANSSTSAASNGSQMTPGSGVTIKTEPKDTSSGSSNTSNTATTSSSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSTSTSSSSASSTTASGRVSQHQQQQQQQHTIGAAVSSSCALNPTSSLANLYTSNPSPKSSYTITYPGSGGGGSNRGEKSTHGHQYHHYHHHHGASGHSLKDHHHHHHHRPQRIAFHKRPAQEALFRPGTKPLSLSAAASALAAAVAAATAAGSSSTAANAADTSPGAVSSGDSAADSLELADSCLRSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGNGGGGSTGNSTETQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGSTLSSGIGSLKVRSESSLGAGGSMGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYEVLQGEDNITSTSQLLYDYTCVDVWMNHPVKRMRLAMEENRPVKKNRNLDLYANEHSRTMSTGFGVSSAGLPGSNSVGTVGANGMLMKPGTTSGDSSDTLTETLGGHNGGGGAAGACDNGTSNNGGCQSLLGHGQIKMELGCDGSGGIVGREGATGVAGSGMGSANGTPDRNGPSTGNGDGALLGEHEIKKEKEEKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDMQMSISSGAGSGPGTGPNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSGGGLGGPAGGVGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNMNGSMNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTVNPPLSSTGGVGCASGVGTNGAPTSRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAPAETASGSGSGSGVGVAGGRSKASALAHLGLSGNGSSSSSSAFGGMLGSPAIGSNGDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGNGGSSGTLATTGGASSTVGSASDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGSSTSNPPAAGCSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTNSTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSLSSSATSASVSGGAPGSSSLGSGSMNQPGGNSMGQNRSDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDEKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMTHSRPSSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2997
PositionMiddle
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.477
Instability index53.47
Isoelectric point6.14
Molecular weight314887.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22766
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      14|      15|     711|     724|       1
---------------------------------------------------------------------------
  711-  724 (33.41/25.24)	STHGHQYHHYHHHH
  727-  740 (31.67/23.43)	SGHSLKDHHHHHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     306.29|      49|      51|    1190|    1240|       4
---------------------------------------------------------------------------
  664-  709 (47.17/ 9.06)	GAAVSSS.CA.....L.N.........P....TSS.........LANLytS.....NPS...PKSSytityPGSGGGGSnRG........E
  983- 1027 (38.18/ 6.75)	.GNSSSS.SSS.GS...N.........S....SSNSSSL.....NAL................KTS.....PRSGSTLS.SGigslkvrsE
 1193- 1243 (75.46/20.32)	GGHNGGG.GAA.GACD.N.........G....TSNNGGC.....QSLL..G.....HGQIKMELGC.....DGSGGIVG.RE......gaT
 1244- 1293 (43.60/ 9.23)	.GVAGSGmGSAnGTPDrN.........G....PSTGNGD.....GALL..G.....EHEIKKEKEE.....KGSIFLTD.QD.........
 1527- 1592 (52.44/12.75)	SGGGLGG.PAG.GVGL.GllpiikqelG....NLT.IPQplstpNSLL..GglnnmNGSMNHPYSN.....PPSQGAQS.QP.........
 1852- 1896 (49.42/11.55)	SG...SG.SGS.GVGV.A.........GgrskAS.ALAH.....LGLS..G.....NGSSS...SS.....SAFGGMLG.SP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     239.58|      51|      52|     534|     584|       5
---------------------------------------------------------------------------
  373-  401 (33.25/ 8.25)	............................TSVNETRSNSSS.....NS.NSSSNSNHNNSNQT....A
  403-  450 (55.48/19.52)	PATVI...........PSIAAT.....VLSRANNASERSSgpintTS.NQPATGTIGSSNSP..SMA
  553-  610 (69.17/26.46)	PGSGVT...IKTEPKDTSSGSS.....NTSNTATTSSSSSgggdeNS.SGAANGVDANGNSSvwEIS
  612-  645 (31.99/ 7.61)	PTVKVScccIKCCKRPPSSSSS......T..........S....tSS.SSASSTT............
  759-  807 (49.69/16.59)	PGTK.........PLSLSAAASalaaaV..AAATAAGSSS.....TAaNAADTSPGAVSSGD..SAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.01|      15|      15|    1476|    1490|       6
---------------------------------------------------------------------------
 1476- 1490 (22.49/15.10)	QKQKEQAAAEREKQK
 1494- 1508 (24.52/17.12)	QAEREREQQQQQDQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     478.93|     113|     259|    1340|    1462|       7
---------------------------------------------------------------------------
  826-  905 (81.56/19.92)	.............................................................................NSNSG.SGGTNStgaaagsttP................YGGPPSYCRN.PMSI.......GDSHP.L..PSEGS...P....................................asaaPSPMQP...SSVSQP.TSVPSgdQLITmsPHPP
 1342- 1462 (203.57/75.39)	PSSNH..............................HSvnsGMLSPKELSQMFPTPPSLD...............PHPNSSPG.GGGCLS.........D................GGNAIDTLVDMQMSISSGAGSGPGTGPNL..PNLGS...PQEE.......................PIDDwsfvfL....PPPICPYVGSSKYAPLPSLPS..QLII..PQIP
 1558- 1682 (63.14/15.00)	PLSTPnsllgglnnmngsmnhpysnppsqgaqsqpHS................RPPSVN...............SLPGGIIGsGAGMLS.........P................S..............PAGAGTSGG....LfhPGMGGipvPLRQgmspispatpggsmrvptpqgscP........L....PYP.SPLGGAAAGSPNP................
 1684- 1775 (61.12/13.06)	........................................GSLNFRRTTPLLP.PPPYDvaiaspansvatpssYHSKQFPL.DG...V.........DsggpgsnrgpmtpsstGGGPLGTTVNPPLSSTGGVGCASGVGTN......GA...P.........................................................................
 2369- 2418 (69.54/16.94)	..............................................................................SSLG.S.GSMN.........Q................PGG................NS...MGQNR...SDG....PGQS.......................PMPP..........PPPSTPD.SSQPGDKAPNTP.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      13|      16|    1982|    1994|       8
---------------------------------------------------------------------------
 1982- 1994 (22.67/10.59)	SGNGGSSGTLATT
 1999- 2011 (21.76/ 9.77)	STVGSASDSLPLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.45|      38|    1028|    1294|    1333|       9
---------------------------------------------------------------------------
  914-  956 (68.41/25.78)	QPGTPCLDHL.DKNTPAPTPTDQHdsksiNASPYHTPSHPGGGG
 1295- 1333 (68.03/32.02)	QPSIDDLNQIfDDGGPFNDDPDLH.....NTPPGSNKSCSGSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.89|      43|     501|    2429|    2478|      10
---------------------------------------------------------------------------
 2429- 2478 (66.01/62.94)	QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2934- 2981 (67.88/43.45)	QQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.02|      14|      30|     242|     271|      11
---------------------------------------------------------------------------
  242-  255 (25.21/ 6.99)	PSAGTNGGP..ASPTA
  273-  288 (17.81/ 9.24)	AGGAASGSAtiASPDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.28|      10|      30|     499|     508|      12
---------------------------------------------------------------------------
  499-  508 (17.56/ 8.38)	SMSSALINKS
  532-  541 (17.72/ 8.54)	SMSSSSANSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.65|      25|      30|     315|     339|      13
---------------------------------------------------------------------------
  315-  339 (46.13/29.95)	PHVQKMLDDWSAFYPISNKL.SSMED
  346-  371 (39.52/24.52)	PMVEILVGKLKMRYPTKYVLvADMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.59|      47|      92|    1921|    1971|      14
---------------------------------------------------------------------------
 1814- 1849 (33.35/16.91)	....CNAGAKCV..........GNIRGAD.SGLYlalpGTNWMDsVTAPAE...............
 1921- 1971 (85.60/71.48)	DPIDCQCGFSAV..........VNRRMAHRAGLF....YEDEME.ITGMAEDPAVHkkssLFEFLN
 2016- 2060 (54.64/35.87)	DLLREQC..SVVqsssnsihraVNR...YRGALF....GR.......GL.ESGAVH....LLEYVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.34|      55|     501|    2310|    2368|      15
---------------------------------------------------------------------------
 2310- 2368 (83.90/47.53)	GLN..ELLRLYAQTCQQQLAPYLSKvPSDKSLLdppESHHHTSSLSSSATSASVSG.GAPGS
 2813- 2870 (92.45/42.11)	GINmmDVFKCWDDLPMQQINMTHSR.PSSPSQF...EGNQQSPGESGSKGAGSRDGyGSQDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.60|      30|      37|      10|      46|      16
---------------------------------------------------------------------------
   14-   46 (48.43/52.48)	ED....CHTNFFALTDLCgiRWRQlVLGERPNAAGDP
   48-   81 (51.17/30.87)	DDpvvrSYSKCLAVDILC..VWRR.VVAPKPKPKPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      20|     686|    1103|    1123|      17
---------------------------------------------------------------------------
 1103- 1123 (35.40/28.09)	LLYDyTCVDVWMNHPVKRMRL
 1792- 1811 (36.93/23.50)	LLYD.TALNIFRDHNFKSCTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      12|      28|    1148|    1159|      18
---------------------------------------------------------------------------
 1148- 1159 (22.04/12.13)	MSTGF..GVSSAGL
 1175- 1188 (18.19/ 8.24)	MKPGTtsGDSSDTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22766 with Med13 domain of Kingdom Metazoa
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