<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22766

Description Uncharacterized protein
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEEAQQAQQAAPSAGTNGGPASPTAAGVNGGSSTTPGSPSGAAGGAASGSATIASPDAIEPREVILAPFGLAGTLTGQSYKTSDPHVQKMLDDWSAFYPISNKLSSMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSVNETRSNSSSNSNSSSNSNHNNSNQTATPATVIPSIAATVLSRANNASERSSGPINTTSNQPATGTIGSSNSPSMARNKDTAHETSSVAASPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSAAVILPERVWQDCIMHAAPSPSPSMSSSSANSSTSAASNGSQMTPGSGVTIKTEPKDTSSGSSNTSNTATTSSSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSTSTSSSSASSTTASGRVSQHQQQQQQQHTIGAAVSSSCALNPTSSLANLYTSNPSPKSSYTITYPGSGGGGSNRGEKSTHGHQYHHYHHHHGASGHSLKDHHHHHHHRPQRIAFHKRPAQEALFRPGTKPLSLSAAASALAAAVAAATAAGSSSTAANAADTSPGAVSSGDSAADSLELADSCLRSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGNGGGGSTGNSTETQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGSTLSSGIGSLKVRSESSLGAGGSMGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYEVLQGEDNITSTSQLLYDYTCVDVWMNHPVKRMRLAMEENRPVKKNRNLDLYANEHSRTMSTGFGVSSAGLPGSNSVGTVGANGMLMKPGTTSGDSSDTLTETLGGHNGGGGAAGACDNGTSNNGGCQSLLGHGQIKMELGCDGSGGIVGREGATGVAGSGMGSANGTPDRNGPSTGNGDGALLGEHEIKKEKEEKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDMQMSISSGAGSGPGTGPNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSGGGLGGPAGGVGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNMNGSMNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTVNPPLSSTGGVGCASGVGTNGAPTSRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAPAETASGSGSGSGVGVAGGRSKASALAHLGLSGNGSSSSSSAFGGMLGSPAIGSNGDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGNGGSSGTLATTGGASSTVGSASDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGSSTSNPPAAGCSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTNSTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSLSSSATSASVSGGAPGSSSLGSGSMNQPGGNSMGQNRSDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDEKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMTHSRPSSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2997
PositionMiddle
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.477
Instability index53.47
Isoelectric point6.14
Molecular weight314887.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22766
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      14|      15|     711|     724|       1
---------------------------------------------------------------------------
  711-  724 (33.41/25.24)	STHGHQYHHYHHHH
  727-  740 (31.67/23.43)	SGHSLKDHHHHHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     306.29|      49|      51|    1190|    1240|       4
---------------------------------------------------------------------------
  664-  709 (47.17/ 9.06)	GAAVSSS.CA.....L.N.........P....TSS.........LANLytS.....NPS...PKSSytityPGSGGGGSnRG........E
  983- 1027 (38.18/ 6.75)	.GNSSSS.SSS.GS...N.........S....SSNSSSL.....NAL................KTS.....PRSGSTLS.SGigslkvrsE
 1193- 1243 (75.46/20.32)	GGHNGGG.GAA.GACD.N.........G....TSNNGGC.....QSLL..G.....HGQIKMELGC.....DGSGGIVG.RE......gaT
 1244- 1293 (43.60/ 9.23)	.GVAGSGmGSAnGTPDrN.........G....PSTGNGD.....GALL..G.....EHEIKKEKEE.....KGSIFLTD.QD.........
 1527- 1592 (52.44/12.75)	SGGGLGG.PAG.GVGL.GllpiikqelG....NLT.IPQplstpNSLL..GglnnmNGSMNHPYSN.....PPSQGAQS.QP.........
 1852- 1896 (49.42/11.55)	SG...SG.SGS.GVGV.A.........GgrskAS.ALAH.....LGLS..G.....NGSSS...SS.....SAFGGMLG.SP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     239.58|      51|      52|     534|     584|       5
---------------------------------------------------------------------------
  373-  401 (33.25/ 8.25)	............................TSVNETRSNSSS.....NS.NSSSNSNHNNSNQT....A
  403-  450 (55.48/19.52)	PATVI...........PSIAAT.....VLSRANNASERSSgpintTS.NQPATGTIGSSNSP..SMA
  553-  610 (69.17/26.46)	PGSGVT...IKTEPKDTSSGSS.....NTSNTATTSSSSSgggdeNS.SGAANGVDANGNSSvwEIS
  612-  645 (31.99/ 7.61)	PTVKVScccIKCCKRPPSSSSS......T..........S....tSS.SSASSTT............
  759-  807 (49.69/16.59)	PGTK.........PLSLSAAASalaaaV..AAATAAGSSS.....TAaNAADTSPGAVSSGD..SAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.01|      15|      15|    1476|    1490|       6
---------------------------------------------------------------------------
 1476- 1490 (22.49/15.10)	QKQKEQAAAEREKQK
 1494- 1508 (24.52/17.12)	QAEREREQQQQQDQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     478.93|     113|     259|    1340|    1462|       7
---------------------------------------------------------------------------
  826-  905 (81.56/19.92)	.............................................................................NSNSG.SGGTNStgaaagsttP................YGGPPSYCRN.PMSI.......GDSHP.L..PSEGS...P....................................asaaPSPMQP...SSVSQP.TSVPSgdQLITmsPHPP
 1342- 1462 (203.57/75.39)	PSSNH..............................HSvnsGMLSPKELSQMFPTPPSLD...............PHPNSSPG.GGGCLS.........D................GGNAIDTLVDMQMSISSGAGSGPGTGPNL..PNLGS...PQEE.......................PIDDwsfvfL....PPPICPYVGSSKYAPLPSLPS..QLII..PQIP
 1558- 1682 (63.14/15.00)	PLSTPnsllgglnnmngsmnhpysnppsqgaqsqpHS................RPPSVN...............SLPGGIIGsGAGMLS.........P................S..............PAGAGTSGG....LfhPGMGGipvPLRQgmspispatpggsmrvptpqgscP........L....PYP.SPLGGAAAGSPNP................
 1684- 1775 (61.12/13.06)	........................................GSLNFRRTTPLLP.PPPYDvaiaspansvatpssYHSKQFPL.DG...V.........DsggpgsnrgpmtpsstGGGPLGTTVNPPLSSTGGVGCASGVGTN......GA...P.........................................................................
 2369- 2418 (69.54/16.94)	..............................................................................SSLG.S.GSMN.........Q................PGG................NS...MGQNR...SDG....PGQS.......................PMPP..........PPPSTPD.SSQPGDKAPNTP.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      13|      16|    1982|    1994|       8
---------------------------------------------------------------------------
 1982- 1994 (22.67/10.59)	SGNGGSSGTLATT
 1999- 2011 (21.76/ 9.77)	STVGSASDSLPLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.45|      38|    1028|    1294|    1333|       9
---------------------------------------------------------------------------
  914-  956 (68.41/25.78)	QPGTPCLDHL.DKNTPAPTPTDQHdsksiNASPYHTPSHPGGGG
 1295- 1333 (68.03/32.02)	QPSIDDLNQIfDDGGPFNDDPDLH.....NTPPGSNKSCSGSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.89|      43|     501|    2429|    2478|      10
---------------------------------------------------------------------------
 2429- 2478 (66.01/62.94)	QLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2934- 2981 (67.88/43.45)	QQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.02|      14|      30|     242|     271|      11
---------------------------------------------------------------------------
  242-  255 (25.21/ 6.99)	PSAGTNGGP..ASPTA
  273-  288 (17.81/ 9.24)	AGGAASGSAtiASPDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.28|      10|      30|     499|     508|      12
---------------------------------------------------------------------------
  499-  508 (17.56/ 8.38)	SMSSALINKS
  532-  541 (17.72/ 8.54)	SMSSSSANSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.65|      25|      30|     315|     339|      13
---------------------------------------------------------------------------
  315-  339 (46.13/29.95)	PHVQKMLDDWSAFYPISNKL.SSMED
  346-  371 (39.52/24.52)	PMVEILVGKLKMRYPTKYVLvADMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.59|      47|      92|    1921|    1971|      14
---------------------------------------------------------------------------
 1814- 1849 (33.35/16.91)	....CNAGAKCV..........GNIRGAD.SGLYlalpGTNWMDsVTAPAE...............
 1921- 1971 (85.60/71.48)	DPIDCQCGFSAV..........VNRRMAHRAGLF....YEDEME.ITGMAEDPAVHkkssLFEFLN
 2016- 2060 (54.64/35.87)	DLLREQC..SVVqsssnsihraVNR...YRGALF....GR.......GL.ESGAVH....LLEYVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.34|      55|     501|    2310|    2368|      15
---------------------------------------------------------------------------
 2310- 2368 (83.90/47.53)	GLN..ELLRLYAQTCQQQLAPYLSKvPSDKSLLdppESHHHTSSLSSSATSASVSG.GAPGS
 2813- 2870 (92.45/42.11)	GINmmDVFKCWDDLPMQQINMTHSR.PSSPSQF...EGNQQSPGESGSKGAGSRDGyGSQDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.60|      30|      37|      10|      46|      16
---------------------------------------------------------------------------
   14-   46 (48.43/52.48)	ED....CHTNFFALTDLCgiRWRQlVLGERPNAAGDP
   48-   81 (51.17/30.87)	DDpvvrSYSKCLAVDILC..VWRR.VVAPKPKPKPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      20|     686|    1103|    1123|      17
---------------------------------------------------------------------------
 1103- 1123 (35.40/28.09)	LLYDyTCVDVWMNHPVKRMRL
 1792- 1811 (36.93/23.50)	LLYD.TALNIFRDHNFKSCTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      12|      28|    1148|    1159|      18
---------------------------------------------------------------------------
 1148- 1159 (22.04/12.13)	MSTGF..GVSSAGL
 1175- 1188 (18.19/ 8.24)	MKPGTtsGDSSDTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22766 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDWTSVNETRSNSSSNSNSSSNSNHNNSNQTATPATVIPSIAATVLSRANNASERSSGPINTTSNQPATGTIGSSNSPSMARNKDTAHETSSVAASPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINK
2) ELGNLTIPQPLSTPNSLLGGLNNMNGSMNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPAN
3) GIVGREGATGVAGSGMGSANGTPDRNGPSTGNGDGALLGEHEIKKEKEEKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDMQMSISSGAGSGPGTGPNLPNLGSPQEEPIDDWS
4) INMTHSRPSSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
5) KSSYTITYPGSGGGGSNRGEKSTHGHQYHHYHHHHGASGHSLKDHHHHHHHRPQRIAFHKRPAQEALFRPGTKP
6) LAPYLSKVPSDKSLLDPPESHHHTSSLSSSATSASVSGGAPGSSSLGSGSMNQPGGNSMGQNRSDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKD
7) NLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSGGGLGGPAGGV
8) PSSYHSKQFPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTVNPPLS
9) RVWQDCIMHAAPSPSPSMSSSSANSSTSAASNGSQMTPGSGVTIKTEPKDTSSGSSNTSNTATTSSSSSGGGDENSSGAANGVDANGNSSVW
10) SSSTSTSSSSASSTTASGRVSQHQQQQQQQHTIGAAVSSS
11) VAAATAAGSSSTAANAADTSPGAVSSGDSAADSLELADSCLRSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGNGGGGSTGNSTETQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGSTLSSGIGSLKVRSESSLGAGGSMGSGGGVPMTPSIHSVYSSAHQTAM
12) VGTVGANGMLMKPGTTSGDSSDTLTETLGGHNGGGGAAGACDNGTSNNGGCQSL
13) VRLLTMRHLEEAQQAQQAAPSAGTNGGPASPTAAGVNGGSSTTPGSPSGAAGGAASGSATIAS
370
1549
1235
2831
690
2326
1468
1714
516
631
777
1165
223
507
1709
1429
2871
763
2449
1538
1758
607
670
1060
1218
285










Molecular Recognition Features






MoRF SequenceStartStop




1) LAAAVA
773
778