<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22765

Description Uncharacterized protein
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYHQGPLQEKPSSGSAGSSGGMSSTNSGLGLGSGAGGTNPSTIPPPLSSPAGSMHSPASGNPVGGSMHGQQQQQQQQPISPQEEQRIAQRQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLSYAVSKKLAQLINQMAESHNINLNSPDPDGNGGKQSSNEMTDSKSDKQHDKPSKESTNGSVLQSADTNPPKVNPYEMIFAEYLHCSHHRDVVLQLSSILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPTRYENSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILVTLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPIKPSESTSGGSGNGSGNVAGGANAADGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTALENDSYNNTLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLEEGGSSQNKSQFTNHVHLFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSHGMCNAGLGTGPISNKPATSSSPNNGGGMEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAVGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPTPSAHTYNPQFMIDIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSILGNPDESMLDVSMIELGELSPTASARLYSSRQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQHGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPDLSNWLDMVARAAIDVFRVNEFTMSNPDAVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGSKQSSHLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPIPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATPAAQVQQSQPQQPIMPAIVPQTAAGPQQIQQMQQQQQQQQQQQQQQMQQQSLQQQQHLQQQQQQQLHLQQQQAQQQQHLQQQQQQQLQQLQQQQQQQLQQQQQQNQMMMQQQQQSNIPQQQQSALQQQQQQLGAQQPQQQVAMTPQQTLQQMQNSNMGAMQMGGPMNTMNQQHMQQQYGQANPAQLVAQANIGGMQTGMGGLGTGMGGGMLNQQQQQAAQQQQPQQAQQAQQAQQAQQQQQQQQQPQGNANMGFVGNVNPMAQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQPQAQAQQQQQTPQQAQQASQQQGPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPTGFMQPQQQQQQPQRNPQQQFMRGPLRAGMPGNPIVGAQPGMGPMNPAMAGGNAGIGATSGGAVMGTQSMAAGGMMGAGQGAQTQQTTGGIMNQNAPAMMGTTGGSIMGQSGGSMIQTGMMNPQQNPALVGQGMGNSGGIGGAGGMAGNSGMGGSAGGMGASGGGMVTSGGMVSAGMGNAGIGNAAPMGGGQGGMGGTSGMPNAGGMGNPSMGNPGMGMQNMQQSSNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGGMMGNFNQMAQQQRTTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMAQNQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
Length2774
PositionKinase
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.617
Instability index53.21
Isoelectric point6.78
Molecular weight303526.77
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     238.10|      18|      18|    2025|    2042|       1
---------------------------------------------------------------------------
 2012- 2031 (33.46/ 8.98)	QQQ.QQQQQQQqqmQQQSLQQ
 2032- 2052 (37.37/11.02)	QQHLQQQQQQQlhlQQQQAQQ
 2105- 2122 (27.87/ 6.07)	QQQQLGAQQPQ...QQVAMTP
 2199- 2215 (34.97/ 9.77)	QQP.QQAQQAQ...QAQQAQQ
 2259- 2275 (41.46/13.15)	QQHQQQQQQQQ...QQQQ.QQ
 2297- 2314 (29.29/ 6.82)	QQGPQQGPQQG...SQQGPQT
 2372- 2387 (33.68/ 9.10)	MQPQQQQQQPQ...R..NPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     578.00|      64|      64|    2501|    2564|       2
---------------------------------------------------------------------------
 2127- 2186 (74.96/21.39)	QQMQ........NSNM....GAM..QMGGPM.........N................T.M..N.....QQH..M.QQQ........ygqanpaqlvaqaniGGMQT.G.............MG..G.......LGTG..MGGG
 2221- 2258 (36.51/ 6.69)	QQPQ.......GNANM....GFV..GNVNPMAqlaqqqgGN................QQW..G.....G.YGSM.Q...................................................................
 2407- 2447 (70.51/19.69)	QPGM........................GPM.........N................PAM..A.....GGNAGI.GA......TSG...............GAV.................MGTQS.......MAAGGMMGAG
 2448- 2492 (59.11/15.33)	QGAQ...T........qqttGGImnQNAPAMM.......GT................T....G.....GSI..M.GQSG......G...............SMIQT.G.............M..M..........N.....PQ
 2493- 2559 (118.65/38.09)	QNPA...LvgqGMGNS....GGI..GGAGGMA.......GN................SGM..G.....GSAGGM.GASGGGMVTSG...............GMVSA.G.............MGNAG.......IGNAAPMGGG
 2560- 2620 (94.43/28.83)	QGGM...GgtsGMPN............AGGM........GN................PSM..G.....NPGMGM.QNMQQSSNMQG...............GMFQGqN.............VPYQN.......VNQNYPNYGN
 2621- 2681 (66.67/18.22)	QG..........MGQQ....GGQ..GG..GMM.......GN...............fNQM..AqqqrtTQAEFL.AQQRAAM......................AA.G.............RGQYGqhapnvtMGN...MGVN
 2682- 2769 (57.15/14.58)	QGAVppyP...RQGGK....PGV..GG..NMA.......QNqqqfqqqrmrlimqqhSGMgqG.....GNAQGMmQNQGQGMST........................qqtpnlvaqlqrqMPNQN.....nmMGQQYP...H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.38|      16|      16|    2057|    2072|       3
---------------------------------------------------------------------------
 2057- 2072 (35.65/ 9.44)	QQQQQQQLQQLQQQQQ
 2076- 2091 (35.02/ 9.14)	QQQQQQNQMMMQQQQQ
 2319- 2334 (29.71/ 6.67)	QQQQQQQQMFYSGMGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.50|      18|      21|    1348|    1368|       5
---------------------------------------------------------------------------
 1349- 1368 (26.09/26.20)	GI.LVVGDATAHKvsSIFGTG
 1372- 1390 (27.40/13.33)	GLnTPVHPGSTPK..SMAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      20|      25|    1733|    1756|       6
---------------------------------------------------------------------------
 1733- 1756 (25.70/29.09)	GLFDaIMKNA...TSTTDwaiLFAQLI
 1759- 1781 (28.93/16.78)	GVID.LSNNSelfTTTLD...MLATLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.07|      12|      24|    1576|    1587|       8
---------------------------------------------------------------------------
 1576- 1587 (20.96/13.25)	PDAVKQEKVKPS
 1599- 1610 (20.11/12.37)	PSAVQGRILKVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.64|      16|      16|    1458|    1473|      11
---------------------------------------------------------------------------
 1453- 1470 (25.41/15.62)	QHVlrQICSQEWVLERCL
 1471- 1487 (24.23/14.48)	QHA.eELCQHGMLIDNLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22765 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGLGTGPISNKPATSSSPNNGGGMEDDVLQTDF
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTGL
3) GAQQPQQQVAMTPQQTLQQMQNSNMGAMQMGGPMNTMNQQHMQQQYGQANPAQLVAQANIGGMQTGMGGLGTGMGGGMLNQQQQQAAQQQQPQQAQQAQQAQQAQQQQQQQQQPQGNANMGFVGNVNPMAQLAQQQGGNQQWGGYGSMQQQHQQQQQQQQQQQQQQQPQAQAQQQQQTPQQAQQASQQQGPQQGPQQGSQQGPQTQQQLQQQQQQQQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPTGFMQPQQQQQQPQRNPQQQFMRGPLRAGMPGNPIVGAQPGMGPMNPAMAGGNAGIGATSGGAVMGTQSMAAGGMMGAGQGAQTQQTTGGIMNQNAPAMMGTTGGSIMGQSGGSMIQTGMMNPQQNPALVGQGMGNS
4) GIGNAAPMGGGQGGMGGTSGMPNAGGMGNPSMGNPGMGMQNMQQSSNMQGGMFQGQNVPYQNVNQNYPNYGNQGMGQQGGQGGGMMGNFNQMAQQQRTTQAEFLAQQRAAMAAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGGNMAQNQQQFQQQRMRLIMQQHSGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQY
5) HEHYHQGPLQEKPSSGSAGSSGGMSSTNSGLGLGSGAGGTNPSTIPPPLSSPAGSMHSPASGNPVGGSMHGQQQQQQQQPISPQEEQRI
6) LPLPPEEVDPIPDKLKDDMKADTPSSDQSPAPSTGSKKSKTTRKRKPKATPAAQVQQSQPQQPIMPAIVPQTAAGPQQIQQMQQQQQQQQQQQQQQMQQQSLQQQQHLQQQQQQQLHLQQQQAQQ
7) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
8) SHNINLNSPDPDGNGGKQSSNEMTDSKSDKQHDKPSKESTNGSVLQSADT
9) SMFSKHKDGNGGNNSSNNNSHNHGANSNSSVSSNGSTFGS
769
816
2110
2549
194
1928
1
372
1618
801
851
2505
2774
282
2052
35
421
1657










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLGP
2) RMRLIM
1
2712
13
2717