<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22764

Description Uncharacterized protein
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPNMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGRWFVHPSSNSEGVFGKSSHHASFSFTFFVHGDSTVCTSMDIREHPPVRLLTMRHLEEAQQAQQAAPSAGTNGGPASPTAAGVNGGSSTTPGSPSGAAGGAASGSATIASPDAIEPREVILAPFGLAGTLTGQSYKTSDPHVQKMLDDWSAFYPISNKLSSMEDGSDNVPPMVEILVGKLKMRYPTKYVLVADMDDWTSVNETRSNSSSNSNSSSNSNHNNSNQTATPATVIPSIAATVLSRANNASERSSGPINTTSNQPATGTIGSSNSPSMARNKDTAHETSSVAASPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSAAVILPERVWQDCIMHAAPSPSPSMSSSSANSSTSAASNGSQMTPGSGVTIKTEPKDTSSGSSNTSNTATTSSSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKSNQNCATNSNSGSGGTNSTGAAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGNGGGGSTGNSTETQQQQQQSQSNSNMGNSSSSSSSGSNSSSNSSSLNALKTSPRSGSTLSSGIGSLKVRSESSLGAGGSMGSGGGVPMTPSIHSVYSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYEVLQGEDNITSTSQLLYDYTCVDVWMNHPVKRMRLAMEENRPVKKNRNLDLYANEHSRTMSTGFGVSSAGLPGSNSVGTVGANGMLMKPGTTSGDSSDTLTETLGGHNGGGGAAGACDNGTSNNGGCQSLLGHGQIKMELGCDGSGGIVGREGATGVAGSGMGSANGTPDRNGPSTGNGDGALLGEHEIKKEKEEKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDMQMSISSGAGSGPGTGPNLPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQLIIPQIPTSTCTNLVYKSTRQKQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSGGGLGGPAGGVGLGLLPIIKQELGNLTIPQPLSTPNSLLGGLNNMNGSMNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAAAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQFPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTVNPPLSSTGGVGCASGVGTNGAPTSRSTNIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAPAETASGSGSGSGVGVAGGRSKASALAHLGLSGNGSSSSSSAFGGMLGSPAIGSNGDKTITINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEESGNGGSSGTLATTGGASSTVGSASDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGALFGRGLESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQSSSGSSTSNPPAAGCSALVKGGTLRGIMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTNSTSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSLSSSATSASVSGGAPGSSSLGSGSMNQPGGNSMGQNRSDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGSDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDEKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMTHSRPSSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPDWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2801
PositionMiddle
OrganismAnopheles minimus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.462
Instability index53.12
Isoelectric point5.86
Molecular weight294862.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22764
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    2271.61|     497|     497|    1003|    1499|       1
---------------------------------------------------------------------------
   77-  599 (593.60/185.56)	........................PKPEPD.PNMFdmsIPGTGN.S...GSVVHP...PLS..LTAAKElwifWYGEE.PDLT...DLvaPELLNSSEAGDKGSWENGLSyeCRSLLFKALHNVIERCLlsrgfvRIG.....RWFVHPSSNSeGVFGKSSHHASF......SFTF......FVHGDSTVCTSMDIREHPPVRlltmrhleeaqqaqqaapsagtnggpaSPTA....................AGVNGGSSTTPG..SPSGAAGGAASGSATIASPDAIEPREvilAPFGLAGTLTGQSYKTSD...PHVQKmlDDWSAFYPISNKLSSMEDGSdnvppmveILVGKLKMRyPTKYVLVADMDDWTSVNETRS..NSSSNSN.SSSNS..NHNNSNQTATPATVI.PSIAATVLSRANNASERSSGP.INTTSN.QPATGTIGSSNSPSMARNKDTAHETSSVAASPTGTLRQRNHHKSmmtP..................pltvPESPSN.D.....LGNPLsmsSALINKSAAVILPERVWQDCIMHAAPSPSPSM...SSSS..ANSSTSAASNGSQ.M.TPGSGVTIKTEPKDTSSGSSNTSNTA..TTSSSSSG..GGdenSSGAANGVD
  600-  905 (384.97/117.47)	AnGNSsvweisdPTVKVSCCCIKSNQNCATnSNSG...SGGTNSTGaaaGSTT.PYGGPPSycRNPMSI....GDSHPlPSEG...S...PASAAPSP...MQPSSVSQP..TS............VP........SGdqlitMSPHPPAS...NNPRSVQPGTPCldhldkNTPAPTPTDQHDSKSINASP.....YHTPSH........................pggGG...............................NGG..GGS...................................TGNSTETQQQQQQSQSN..S............................................................NM..GNSSSSSSS..GSNS.......SSNS.SSLNALKTSPRSGSTLSSGIGSLKVRSESSLGAGGSMGSGGG.....VPMTPSIHSVYSSAHQTAMA.NNLAS...K......................RE..............SI...LQMLQSLKR...............PSLFCKD..YEVL.......................................QGEDN......I..TST..S.............
  906- 1343 (688.09/216.40)	.................................QL...LYDYTCVD...VWMNHPVKRMRL..AMEENR....PVKKN.RNLDlyaNE..HSRTMSTGFGV...........SSAGL..PG..................................SNSVGTVGANG......MLMKPGTTSGDSSDT...........LTETL.....................gghnggGGAA....................GACDNGTSNNGG..CQSLLGHGQIKMELGCDGSGGIVGRE...GATGVAGSGMGSANGTPDRNGPSTGN..GDGALLGEHEIKKEKEEKGS........IFLTDQDLQ.PSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSCSGS..GGFSEESKRFPSSNH.HSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGNAIDTLVDMQMSISSGAGSGPGTGPNLPNLGS...P......................QEEPID.DWSFVFLPPPI...CPYVGSSKYAPLPSLPSQLIIPQIPTSTCTNLVYKSTRQ..KQKEQAAAEREKQKLREQAEREREQQQQQDQQQNSQSDSNNAQSTGASGTSG..GG...LGGPAGGVG
 1344- 1806 (604.95/189.26)	L.GLL.......PIIKQELGNLTIPQPLST.PNSL...LGGLNNMN...GSMNHPYSNPPS..QGAQSQ....PHSRP.PSVN...SL..PGGIIGSGAGMLSPSPAGAG..TSGGLFHPGMGGIPVPL......RQG.....MSPISPATPG.GSMRVPTPQGSC......PLPYPSPLGGAAAGSPNPMGSLNFRRTTPLL.....................ppppydVAIAspansvatpssyhskqfpldGVDSGGPGSNRGpmTPSSTGGG....PLGTTVNPPL.SST...GGVGCA.SGVGT.NGAP..TSRSTNI..ETNAL.........................LVNILLY.DTA..LN.IFRDHN.FK.SCTLCVCNAGA..KCVGNirGADSGLYLALPGTNWmDSVT....APAE............TASGSGSGSGVGVAGGRSKASALAHLGL...SGNGSSSSSSAFGGMLGS...PaigsngdktitintdslqngylDEDPIDcQCGFSAVVNR............................RMAHRAGLFYEDEMEitGMAEDPAVHK.KSSLFEFL..............NGTAKAIKMEESGNGGSSGtlAT...TGGASSTVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     853.77|     278|     502|    1968|    2282|       2
---------------------------------------------------------------------------
 1968- 2282 (426.31/242.46)	TIQgPltWRQFHRLAGR.GTGQcepqpipslIVGYekDWLSLAP....YALHYWDKL....LLEPYSYPR..DVAYVAIVPDNDyvvakVRTYFKELSTTYEMCKLGRHTPIK.GWDG....ILRVGSQRVLKETQN..SNLDEwfTNMGVDQQR..KNGtNSTSSGLN..ELLRLYAQTCQQQLAPYLSKvPSDKSLLdppESHHHTSSLSSSATSASVSG.GAPGSSSLGSgSMNQPggNSMGQNRSDGP.GQSP......MPPPPPSTPDSSQPGDKApNTPKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFTCGS....DSPDVERLACLSL
 2473- 2785 (427.46/177.83)	TVQ.P..WRLVVGRIGRiGHGE.........LKGW..SWLLSKPnlqrASKHLKDICeqcsLMHPIAVPSilSACLVTLEPDSD.....LRVMSDQFTPDERFSQRSMQSPLStPQDAtcthILVFPTSAKAQSAQAsfSVIGE..LDLGEDLNMviMDG.DDDDDGINmmDVFKCWDDLPMQQINMTHSR.PSSPSQF...EGNQQSPGESGSKGAGSRDGyGSQDSEEVGL.VLQQP..LAIGYLVSTAPtGRMPdwfwssCPHMENVCPVFLRTALHL.HSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNLLSwlamDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.74|       9|      33|      31|      40|       4
---------------------------------------------------------------------------
   31-   40 (14.18/11.85)	WRQlVLGERP
   67-   75 (18.56/10.33)	WRR.VVAPKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22764 with Med13 domain of Kingdom Metazoa
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