<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22762

Description Uncharacterized protein
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSNMFDMSIPGTGSSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGKWFVHPSSNGERVFGKSSHHASFSFAFFVHGDSTVCTSMDIREHPPVRLLTMKHLEEAQQAQQAAPGGSANGPASPSAGGVSAASGSASPNSPAVGSGAAAGSNGSTSAVAGAIEPREVILAPFGLAGTLTGQSYKASDPHTQKILDDWSAFYPISNKHSGMSSDGSDNVPPIVEILVGKVKMRYPSKYVLVADMDDWTSSGDTRSSSSSSSSTTNSSSSSSNSNSNQTTVPPTTASSIAASVLSRIHSSTERSVSGSAINSTSNQPAAPASTGSSTSAATARPKDTPGETGSSSATPSPTGTLRQRNHHKSMMNPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAPAPASAVSNGTSGTTTTTTSTTTTGSVTIKTEPKDTNSSGSNSSGSNNTTSGIGGGDENSSGAANGVDANGNSSVWEISDPTVKASCCCIKSNQNCAANSGSGGGGASNTTGSAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPSTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGVSGGSTGGGNTTEGGQQQQQTQTGSGLSSGSSSSGSNSSSGNSALKASPRSSLSSSVIGSLKVRSESSLGASSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQTLKRPSLFCKDYETLQSEDIPSTSHLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMSTGFGGSNVAGMPGGNSASGGSTNGMLMKGAAEASDALAEALSGGGGRSGNGGACDSAASNNGGCPPMLGQIKMELGCDGSGGGVQGAAGAGIGSANGGTPDRNGATAGNGEGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGTGSGAGSGNVSVIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPTLPSQQVMPPIPTSTVANLVYKSTRQKQKEKAAAEREKQKLREQAEREREQQQQQDQQQNAQSESSTQSTGGSGPPGGGINPPVGGIGLGLLPIIKPEVGGLTVPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTTTVNQPLSSTGIGCATGGNGAFGVRSSSIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTGPADTAVAATGGSGGRSKASALAHLGLGGSSSSSAFGGMLGSPALGNDKAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEDAGSGGTALVSTGVGASSTAGGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGSLFGRGTESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVEQQSPASSNALVKGGTLRGVMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQQRKNGTGSSSTSSSTGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHASSSGSSSLGGGASSSLGGGSMGQPGGNTMGQNRNDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNSVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSGEKSENTESFGKTSLKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFNVIGELDLGEDLNMVIMDGEDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2757
PositionMiddle
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.426
Instability index53.07
Isoelectric point5.94
Molecular weight289193.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22762
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.98|      28|      28|     768|     795|       3
---------------------------------------------------------------------------
  259-  284 (32.89/ 6.68)	AASGSASPNS.PA......VGSGAAA.GSNGSTS
  561-  588 (34.66/ 7.49)	SVTIKTEPKDTNS......SGSNSSGSNNTTSGI
  747-  779 (34.99/ 7.65)	SKSINASPYHTPShpgggvSG.GSTGGGNTTEGG
 1400- 1424 (35.45/ 7.86)	SGAGMLSP..SPA.......GAGTSGGLFHPGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     980.76|     146|     211|     378|     538|       4
---------------------------------------------------------------------------
  378-  534 (201.24/49.84)	....G..D......................................TRSSSSSSSSTTNSSSSSSNS.....................NSNQTTV.....PPTTAS........SIAASVLSRIHSSTERSVSGSAINS.TSNQ..PA.ApastgsstsaatarpK...........D.............TPGETGS..................SSATPSPTGTLRQ....RNHHKSMMNP.PLTVPES.PSND.....LGNPLS..............MSSALINKSPAV.ILPER............VWQD..CIMH
  591-  731 (146.22/34.31)	....G..D...........................................ENSSGAANGVDANGNS.....................SVWEISD.....PTVKASccciksnqNCAAN..SGSGGGGASNTTGSAAGS.TTPY..GG.P...............P...........SycrnpmsigdshpLPSEGSP..................ASAAPSP.................MQPsSVSQPTSvPSGD.......QLIT..............MSP....HPPAS.NNPRS............VQPStpCLDH
  738-  880 (124.34/28.13)	APTPT..DqhdsksinaspyhtpshpgggvsggstgggntteggqqQQQTQTGSGLSSGSSSSGSNS.....................SSGNSAL.....KASPRS........SLSSSVIGSLKVRSESSLGASSG...........................................................GG..................VPMTPS.IHSVFS....SAHQTAMANN.LASKRES.I............LQ..............MLQTL..KRP..............................
  947- 1090 (124.72/28.24)	..................................................STGFGGSNVAGMPGGNS.....................ASGGSTNgmlmkGAAEAS........DALAE...ALSGGGGRSGNGGACDSaASNN..GGcP...............PmlgqikmelgcD.............GSG..GG..................VQGAAG.AG.IGS....ANGGT..........PDR.NGAT.....AGNG.................EGALLGEHE...IKKEKedkgsifltdqdLQPS...IDD
 1097- 1269 (173.44/42.00)	DGGPFndD......................................PDLHNTPPG..SNKSSSGSGG.....................FSEESKR.....FP...S........SNHHSVNSGMLSPKELSQMFPTPPS.LDPH..P..................N...........S.............SPGGGGClsdggiaidtlvdlqmslSSGTGSGAGS.........GNVSVIPN.LGSPQEE.PIDDwsfvfLPPPICpyvgsskyaplptlPSQQVMPPIPTS.TVANL............VYKS..TRQK
 1293- 1394 (126.34/28.70)	QQQQQ..D........................................QQQNAQSESSTQSTGGSG..................................PP......................GGGINPPVGGIGLG......llPI.I.........................................KPEVGGL..................T..VPQPLSTPNSllggLNNLNGSLNH.PYSNPPS.QGAQ......SQPHS.....................RPPSVnSLP........................
 2062- 2170 (84.46/16.88)	.......D......................................QQQRKNGTGSSSTSSSTGLNEllrlyaqtcqqqlapylskvpSDKSLLD.....PPESHA........SSSGS..SSLGGGASSSLGGGSMGQ...PG..GN.T..........mgqnrN...........D.............GPGQ.....................SPMPPPPPSTPDS....S.......................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.76|      85|     450|    2211|    2301|       5
---------------------------------------------------------------------------
 2211- 2301 (134.01/125.05)	PHIVLYIVEPFTCG.......NDSPDVERLaCLSLLRC....YS.NILNSVPDSIR...........SNISVQIisLESILElGRN.RNRLRLS....DHMRCLALSVfsQSRKYLAHM
 2640- 2752 (121.75/90.97)	PLAIGYLVSTAPTGrmpewfwSSCPHMENV.CPVFLRTalhlHSpTILQNTDDPLQqnqsstehpldSNITADV..LRYVLE.GYNlLSWLAMDsnthDRLSCLPIHV..QVLMQLYHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.34|      27|     115|    1634|    1664|       8
---------------------------------------------------------------------------
 1634- 1664 (42.63/26.56)	GPADTAVAATGGSGGrskaSALAHLGLGGSS
 1750- 1776 (46.71/21.48)	GTAKAIKMEDAGSGG....TALVSTGVGASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.11|      16|      28|    1438|    1459|       9
---------------------------------------------------------------------------
 1438- 1454 (28.38/10.18)	SPaTPGGSM..RVPTPQGS
 1468- 1485 (25.72/12.26)	SP.NPMGSLnfRRTTPLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.52|      10|      15|     916|     925|      10
---------------------------------------------------------------------------
  916-  925 (15.85/ 9.25)	VKRMRLAAEE
  932-  941 (16.67/10.09)	IRNLDLYANE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22762 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDWTSSGDTRSSSSSSSSTTNSSSSSSNSNSNQTTVPPTTASSIAASVLSRIHSSTERSVSGSAINSTSNQPAAPASTGSSTSAATARPKDTPGETGSSSATPSPTGTLRQRNHHKSMMNPPLTVPESPSNDLGNPLSMSSALINKSPA
2) ERVWQDCIMHAPAPASAVSNGTSGTTTTTTSTTTTGSVTIKTEPKDTNSSGSNSSGSNNTTSGIGGGDENSSGAANGVDANGNSSVW
3) EVGGLTVPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPA
4) GGVQGAAGAGIGSANGGTPDRNGATAGNGEGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGG
5) LAPYLSKVPSDKSLLDPPESHASSSGSSSLGGGASSSLGGGSMGQPGGNTMGQNRNDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENQLNTSSASPADGMRIDDDGKD
6) NSGSGGGGASNTTGSAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPSTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGVSGGSTGGGNTTEGGQQQQQTQTGSGLSSGSSSSGSNSSSGNSALKASPRSSLSSSVIGSLKVRSESSLGASSGGGVPMTPSIHSVFSSAH
7) PLPTLPSQQVMPPIPTSTVANLVYKSTRQKQKEKAAAEREKQKLREQAEREREQQQQQDQQQNAQSESSTQSTGGSGPPGGGINPPVGGIGLGLL
8) PSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTTTVNQP
9) QINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSE
10) VRLLTMKHLEEAQQAQQAAPGGSANGPASPSAGGVSAASGSASPNSPAVGSGAAAG
372
525
1340
1029
2096
634
1240
1503
2590
223
520
611
1497
1177
2209
855
1334
1547
2631
278










Molecular Recognition Features






MoRF SequenceStartStop




NANANA